A kind of hydrogel coating with long-term antibacterial function and preparation method thereof

Abstract

The invention discloses a hydrogel coating with a long-term antibacterial function and a preparation method thereof. The method comprises the following steps that 1, pre-treatment is conducted on a base material; 2, at room temperature, the base material subjected to pre-treatment is placed in a polycation electrolyte solution and a mixed solution of a polyphenol compound and an antibacterial medicine in sequence, and after reaction is carried out in a polyanion electrolyte solution for 5-20 min, washing is conducted for 3-5 times; 3, operation of step 2 is repeated for 5-20 times to obtain the hydrogel coating. The method is simple and convenient to operate and cheap in raw material, and the prepared hydrogel coating has good biocompatibility and excellent antibacterial performance; the hydrogel coating has good medicine loading capacity and stable medicine releasing performance, and can be used for preparing and modifying cardiovascular implant endovascular devices, orthopedics filling materials and antibacterial wound dressings.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a hydrogel coating with long-term antibacterial function and a preparation method thereof. The coating can be widely used in surface modification of cardiovascular implant devices and modification of orthopedic filling materials. properties and wound dressing materials. Background technique [0002] Due to the invasion of bacteria into interventional medical devices, surgical instruments, wound gauze, sutures and other materials, wound infection and operation failure are often caused, and life and health are seriously threatened. At present, the preparation of materials with good antibacterial function is a common concern of various industries. For example, contact lenses with antibacterial coatings have a better ability to prevent bacterial contamination; catheters with antibacterial coatings can better prevent patients from suffering secondary injuries (b...

AI Technical Summary

Problems solved by technology

[0003] The existing antibacterial materials mainly have the following problems: 1) Antibacterial medical devices are often quickly wrapped by proteins in the body after being implanted in the human body, which is easy to cause the adhesion of microorganisms, and the adsorbed proteins hinder the release of antibacterial drugs, which is easy to cause bacterial infection ; 2) In order to prevent the implant from being infected by bacteria, the doctor soaks the implant device in the drug solution before the operation, but due to the small amount of drug absorbed, the drug is easy to fall off and the operation time is long, and the patient's low immunity will cause The antibacterial effect is poor, and the implant is excreted abnormally by the body and often requires reoperation; 3) The coating material deposited on the surface of the medical device through non-covalent interaction has defects such as limited drug loading, easy to be affected by environmental stimuli, and poor stability; 4) It has been reported in the literature that the coatings prepared by covalently grafting antibacterial drugs with polyelectrolyte molecules have good structural stability, but the preparation process of this method is complicated and the drug activity is low, which is difficult to promote

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