Preparation method of molecular sieve coating doped with functional atoms on the surface of medical implant material

An implant material and molecular sieve technology are applied in the field of preparation of molecular sieve coatings doped with functional atoms on the surface of medical implant materials to achieve the effects of improving corrosion resistance, promoting proliferation and differentiation, and reducing release

Active Publication Date: 2017-01-25
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the introduction of functional elements (Mg, Zn, Ca, Cu, Sr, etc.) into pure silicon molecular sieves (Silicalite-1) for the surface treatment of new generation medical implant materials

Method used

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  • Preparation method of molecular sieve coating doped with functional atoms on the surface of medical implant material
  • Preparation method of molecular sieve coating doped with functional atoms on the surface of medical implant material
  • Preparation method of molecular sieve coating doped with functional atoms on the surface of medical implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 1g Silicalite-1 molecular sieve seed crystal and ultrasonically disperse it in 50mL aqueous solution to prepare a white seed crystal solution.

[0037] TiNb alloy (TiNb mass percentage 70%, Nb mass percentage 30%) was respectively placed in acetone, deionized water, ethanol, ultrasonic cleaning 10min, then soaked in 30wt% hydrogen peroxide solution for 30min, make the surface with more Hydroxyl groups were rinsed with a large amount of deionized water and dried with nitrogen gas.

[0038] The pretreated TiNb alloy material was immersed in the prepared seed crystal solution for 15 minutes, dried at room temperature, and placed in an oven at 110° C. for 2 hours.

[0039] Mix and stir 0.22g tetrapropylammonium bromide, 0.042g potassium hydroxide, and 15mL deionized water evenly, then add 0.84mL tetraethyl orthosilicate and 0.025g calcium nitrate, and continue stirring for 12 hours to obtain a precursor solution. Two TiNb alloy discs (diameter 8mm, thickness 1mm) obt...

Embodiment 2

[0041] Mix and stir 0.38g tetrapropylammonium bromide, 0.03g potassium hydroxide, and 20mL deionized water evenly, then add 1mL tetraethyl orthosilicate and 0.02g zinc chloride, and continue stirring for 24h to obtain a precursor solution. Two TiNb alloy discs (diameter 8 mm, thickness 1 mm) pre-coated with seed crystals in Example 1 were fixed in a reaction kettle with a volume of 15 mL, 10 mL of precursor solution was added, and hydrothermal reaction was carried out at 150 °C for 24 h. After cooling to room temperature, ultrasonically clean them with deionized water and dry them, place them in a muffle furnace for calcination at 600°C for 0.5h, and heat up at a rate of 0.5°C / min. After natural cooling, the Silicalite-1 molecular sieve function doped with Zn atoms is obtained. Thin TiNb alloy material, the thickness of the coating is about 15μm.

Embodiment 3

[0043] Mix and stir 0.1g tetrapropylammonium bromide, 0.05g potassium hydroxide, and 10mL deionized water evenly, then add 0.6mL tetraethyl orthosilicate and 0.023g magnesium acetate, and continue stirring for 5 hours to obtain a precursor solution. A TiNb alloy disc (diameter 8 mm, thickness 1 mm) pre-coated with seed crystals in Example 1 was fixed in a reaction kettle with a volume of 15 mL, 10 mL of precursor solution was added, and hydrothermal reaction was carried out at 230 ° C for 5 h. After cooling to room temperature, ultrasonically clean them with deionized water, dry them, and place them in a muffle furnace for calcination at 400°C for 6h with a heating rate of 2°C / min. After natural cooling, Mg atom-doped Silicalite-1 molecular sieve functionalized TiNb alloy material, the thickness of the coating is about 5 μm.

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Abstract

The invention provides a preparation method of a medical implant material surface function atom doped molecular sieve layer and belongs to the technical field of preparation of the molecular sieve layer having high biological activity. New-generation medical implant alloy materials (a bone repair material, a dental implant material and a cardiovascular implant material) having low elasticity modulus and high biocompatibility are used as a substrate, a Silicalite-1 type molecular sieve layer doped with different function atoms grows on the surface of the substrate by means of a co-synthesis method, and accordingly the biological activity, corrosion resistance and bone growing induction capacity of a composite material is improved. The preparation method is suitable for various low-elasticity-modulus medical implant materials, has the advantages of being moderate in preparation conditions, simple in process, low in cost and the like, can be applied to implant materials of any shapes and surface roughness and shows the potential of further development of novel hard-tissue implant materials.

Description

technical field [0001] The invention belongs to the technical field of preparation of molecular sieve coatings with high biological activity, and specifically relates to a method for preparing molecular sieve active coatings doped with functional elements on the surface of a new generation of medical implant materials by co-synthesis, so that the medical implants The implant material has good biological activity, corrosion resistance, low elastic modulus and high roughness, realizing the application of the medical implant material in hard tissue substitutes and the like. Background technique [0002] Among biomedical materials, metal materials have high strength and toughness, good corrosion resistance and biocompatibility, and are widely used in the repair and replacement of hard tissues in the human body. Corrosion and wear of metal materials are unavoidable in the human environment, and the resulting dissolution of metal ions has a toxic effect on human tissues and affect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C18/00A61L27/30
CPCA61L27/30C23C18/00
Inventor 于吉红李冬冬李元元
Owner JILIN UNIV
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