48 results about "Anti hyperglycemic" patented technology

The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoprotein-emia (such as chylomicrons, VLDL and LDL), and to regulate body fat and more generally lipid stores, and, more generally, for the improvement of metabolism disorders, especially those associated with diabetes, obesity and / or atherosclerosis.

A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative and a disintegrating agent is herein disclosed and described. The dosage formulation exhibits a significant increase in bioavailability of the thiazolidinedione derivative component compared to conventional immediate release dosage forms containing only a thiazolidinedione derivative.

The present invention relates to a novel hypoglycemic / anti-hyperglycemic protein named ADMc1 purified from the seeds of Momordica charantia for control of hyperglycemia. The process for the purification of novel hypoglycemic / anti-hyperglycemic protein named ADMc1 is also disclosed. The invention also relates to process for preparation and purification of the recombinant novel hypoglycemic / anti-hyperglycemic protein of Momordica charantia, named rADMc1. Both ADMc1 and rADMc1 are highly effective and need to be administered only once a day to maintain normal blood glucose levels. The procedure involves purification of a novel hypoglycemic / anti-hyperglycemic protein of M. charantia, construction of cDNA library from M. charantia seeds, screening of cDNA library using oligonucleotide probe designed on the basis of amino acid sequence of the tryptic fragment of the protein, cloning of the cDNA in a eukaryotic expression system, expression and purification of the recombinant protein.

The invention relates to the technical field of protein extraction. In order to solve the problem of a large number of by-products and low resource utilization in the processing of Japanese croaker, a method for preparing a biological source dipeptidyl peptidase-IV inhibitor is provided, comprising the following steps: Steps: (1) pretreating the skin of Japanese yellow croaker to obtain skin powder, then extracting collagen from the fish skin powder, and centrifuging and drying to obtain skin collagen of Japanese yellow croaker; (2) using compound enzymes to process ( 1) enzymatic hydrolysis of the obtained Japanese croaker skin collagen to obtain the Japanese croaker skin collagen peptide; (3) screening the Japanese croaker skin collagen peptide with a dipeptidyl peptidase screening kit, namely Obtain biological source dipeptidyl peptidase-IV inhibitor. In the present invention, the dipeptidyl peptidase-IV inhibitory peptide is prepared by using the skin of Japanese yellow croaker fish as the main raw material through a relatively efficient process. Good anti-hyperglycemic effect.