The invention discloses an asymmetric synthesis method of a gamma-alkenyl substituted
butenolide or butenolactam compound. The method adopts cheap
nickel to catalyze a [3+2] asymmetric
cycloaddition reaction of a cyclopropenone compound and alpha, beta-
unsaturated ketone or
imine, the selective
insertion reaction of intermolecular C=X after
nickel-catalyzed C-C bond activation is realized for thefirst time, wherein X is equal to O or N, the gamma-alkenyl substituted
butenolide or butenolactam compound is obtained in a high yield, high enantioselectivity and
chirality controllable manner, thesynthesis method is novel, condition mildness, substrate with good applicability, simple and efficient reaction, cheap and readily available catalyst, according to the present invention, the synthesisprocess is simple, the
atom economy is good, the synthesis product is easy to derivatize, the method can be widely used in completely-synthesized designed synthesis building blocks and new chiral
drug derivatives, and the ligand compound is further provided, and can be used for the asymmetric synthesis of gamma-alkenyl substituted
butenolide or butenolactam compounds.