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Methods and devices for isolating and diagnosing disease with a cell adhesion matrix system, mimicking a metastatic, cardiovascular or placental environment, are disclosed. The cell adhesion matrix facilitates the enrichment of target cells such as metastatic tumor cells, fetal cells and endothelial progenitor cells from a fluid sample such as blood for diagnostic and therapeutic applications in treating patients afflicted with disease, such as cancerous, cardiovascular and fetal diseases, as well as for research applications in molecular analysis of metastatic, and cardiovascular and fetal diseases. Blood test prototypes and methods for the cell enrichment and detection of circulating tumor and endothelial cells using multiplex molecular analysis are described herein. In addition, methods and compositions for determining host immunity to tumor in subjects with risk of cancer progression and methods for isolating an enriched fraction of fetal cells from pregnant females for prenatal diagnosis are also described herein.

A method, system, and computer program product for storing and retrieving patient data in a database connected to a network is disclosed. The method, system, and computer program product comprises storing clinical data in the database, extracting data from the clinical data, querying the database using a taxonomy that includes inclusive or exclusive search criterion, and receiving a result set. The method, system, and computer program product comprises creating a taxonomy that includes at least one search criterion, sending a query to the database, the query including said at least one search criteria, receiving the result set in response to the query, the result set including at least one result record, and displaying said at least one result record. The method, system, and computer program product can further include a user such as a clinical researcher, a treating physician, or a consulting physician analyzing the result set.

An automotive vehicle courtesy message display system allows the driver of a automotive vehicle to visually display courtesy messages to the drivers of vehicles located to the rear. Such messages may be for an occasional urgent request to "cut in" for safe passage. The message display system provides the driver of the vehicle in which the visual display is installed with an audible feedback so that the vehicle driver can verify that the correct message has been selected, without visually distracting the driver's attention. The system includes three main components, namely a wireless control unit located on the vehicle operator's steering wheel, a processor unit containing most of the electronics of the system positioned in an unobtrusive location so as to avoid impairing the drivers view, and one or a pair of display screens which are typically located behind the rear seat headrests of an automotive passenger vehicle. A microprocessor controller withing the microprocessor unit selects a text message corresponding to the particular touch sensor depressed, and transmits it to an appropriate one the display screens. The audible announcement of the message selected by the touch sensor provides the operator with a positive feedback indicating selection of the correct message.

A device (1) is designed for locating a region which is situated in a body (10). The device has a fluid-filled reservoir (30) which is closed off in a sealed manner by a displaceable plunger (32) and is connected to a hollow puncture needle (20). To measure the pressure prevailing in the fluid, the device has a pressure gauge (40). A signal converter (50) is used to convert a continuous pressure-measurement signal provided by the pressure gauge (40) into a form which is suitable for further processing. A synthesizer (60) is designed to process the converted pressure-measurement signal into a continuous sound signal which is representative of the pressure. If, during a displacement of the puncture needle (20), a needle point (21) reaches the anatomical cavity (15), the result is a readily perceptible change in the sound signal. The device records the pressure-measurement signal over the course of time.

A single-chain-end functionalized polyolefin, which is represented by the following general formula (I):

P—X  (I)

wherein X is a group containing at least one element selected from oxygen, sulfur, nitrogen, phosphorus and halogens, P represents a polymer chain made mainly of an olefin composed only of carbon and hydrogen atoms, and X is bonded to a terminal of P, wherein the molecular weight distribution (Mw/Mn) obtained by gel permeation chromatography (GPC) is from 1.0 to 1.5.

The present invention provides an organic light emitting diode comprising a substrate; a transparent cathode; an anode; and an organic material layer interposed between the transparent cathode and the anode, wherein the organic material layer comprises a light emitting layer and an n-type doped electron transport layer, the n-type doped electron transport layer includes an electron transport material and an n-type dopant and is disposed between the transparent cathode and the light emitting layer, and a method for manufacturing the same.

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

A system and method is provided for the real time auditing of covert data marks. Specific information relating to a product or document is entered into an information cell or shell from a product data file. A high definition, high resolution, high speed inline video system is provided to take specific details from the individual product or document, which details are added to the data cell or shell. Details are then inspected, quality checked, matched in the event there are multiple identifiers (e.g., currency would normally carry two matching sequential numbers), and verified to the product order. This cell or shell is passed to the special design computer/controller through a high speed electronic interface. Information entering the computer/controller is once again verified and matched to the original data as well as the product or document. The cell or shell is converted into a specially created 2-dimensional bar code which is encrypted by the computer/controller and then transformed into a video rip. This video rip is sent to high quality/high resolution production print engines. The encrypted 2-dimensional bar code is imaged directly to the product or document as it is carried past the print imaging engines. The ink also is specially designed and manufactured for this system and process. It is an invisible ink which is unique, durable, permanent and not available commercially (covered under trade secrets). These special inks are well suited for delivery using inkjet technology to efficiently make well formed invisible images at slow to high speed production schemes. The product or document is then sent instantly into a drying scheme (this can be air, forced air, heat, UV Dryer, depending on the printing system selected). After drying there is a final scanning. This scanning equipment is the same scanner design which will be used in the field so that each product or document will be verified with the actual scanning device and programs which will be used in the field. From this final scanning of the 2-dimensional data bar code, a final audited product or document profile is created, as is a database which will be the point of reference in the infrastructure during the life of the product or document. Each time any product or document is scanned at a transaction point, the database will be updated, either in real-time or downloaded from a data collection scanning device. This will build a complete history from the point of manufacture to the moment it is removed from service.

A photolithographic track system and method for semiconductor wafer manufacture having a plurality of stations for receiving a wafer for sequential processing, including a first group of stations for performing at least a part of a photolithography process. A metrology station is provided in a position of the track system after the first group of stations, for determining whether the processed wafer is within tolerance for at least one critical dimension. If not within tolerance, the wafer is moved by the track system to a stripping station for removal of at least one layer and a return to the beginning of the first group of stations for repeating the performance of a photolithography process. Parameters may also be adjusted for purposes of the repeated performance of the process. If within tolerance, the wafer may be moved for further processing, for example, baking or off loading.