The invention discloses a device and method for preparing multi-bottle mixed gas, belonging to the field of mixed gas distribution. The device includes dilution gas raw material gas cylinders, component gas raw material gas cylinders, weighing devices, pressure reducing valves, first ball valves, second ball valves, high vacuum baffle valves, vacuum pressure gauges, vacuum pumps, venting control valves, exhaust Empty pipelines, raw material gas main pipelines, precision pressure gauges, product gas manifolds, needle valves, and product gas cylinders; the product gas manifold contains multiple gas pipelines, and the number of needle valves and product gas cylinders is the same as the number of gas pipelines. The quantity is equal. The steps of the method are as follows: Step 1, pipeline connection; Step 2, pipeline evacuation; Step 3, pipeline gas replacement; Step 4, mixed gas preparation; Step 5, pipeline evacuation. The low-concentration gas is prepared by using the device and method of the invention, which reduces the weighing error, improves the gas distribution accuracy, has fast gas distribution speed, is suitable for mass production, and saves the gas distribution cost. And the device is simple, and the method is easy to operate.