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42results about How to "Regulated release" patented technology
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Injectable self-sealing gel applicable to drug loading and releasing and preparation method and application thereof
ActiveCN107007881AImprove liquidityGood injectabilityAdditive manufacturing apparatusPharmaceutical delivery mechanismSelf-healingSide effect
The invention discloses injectable self-sealing gel applicable to drug loading and releasing and a preparation method and application thereof. Macromolecular microgel particles with surface charge are used herein, and colloidal gel is obtained by self-assembly through static mutual action of the particles. Since static actions in the microgel are physically crosslinked and are reversible; the colloidal gel of the invention has good injectability and self-healing property, no chemical crosslinking reaction needs to be introduced during injection and curing, the gel is different from chemical macromolecules and is free of small-molecular crosslinking agents, and the gel is good in biocompatibility, degradable and absorbable, free of toxic and side effects and good in safety and is possibly applicable widely to the field of biomedicine.
Owner:SHENZHEN HUA NOVA BIOTECH LTD
Preparation method of multi-growth-factor slow release coating of titanium and titanium alloy surface
InactiveCN102950102AIncrease fixed amountHigh activityLiquid surface applicatorsCoatingsTitanium surfaceElectric properties
The invention discloses a preparation method of a multi-growth-factor slow release coating of a titanium and titanium alloy surface. According to the method, a plurality of layers of coatings containing nanoparticles of growth factors are prepared on the titanium surface by taking the nanoparticles as a growth factor carrier and charged high molecular thin films as a medium. The nanoparticles included in the coating are prepared by mixing polycation solution containing dopamine of certain concentration with polyanion solution containing the growth factors. The nanoparticles have good dispersibility, can protect the activity of the growth factors and are easy to fix on the surface of a material. By controlling the electric property of the nanoparticles and the high molecular thin films, nanoparticles carrying with different factors are embedded between the high molecular thin films. By adjusting the loading quantity and the loading sequence of different nanoparticles and the thickness of the coatings, effective control over release speed, release quantity and release sequence of the various growth factors can be realized.
Owner:SOUTHWEST JIAOTONG UNIV
Multifunctional ordered medicine release medical coating film for acute trauma and preparation method thereof
ActiveCN108324986AEasy to operateOptimizing Control ParametersAbsorbent padsBandagesFiberElectrospinning
The invention provides a multifunctional ordered medicine release medical coating film for acute trauma and a preparation method thereof. The multifunctional ordered medicine release medical coating film for acute trauma is characterized by comprising fiber formed through coaxial static spinning; the fiber comprises a bleeding stopping and pain relieving layer and an anti-bacterial healing promotion layer arranged in the bleeding stopping and pain relieving layer; the bleeding stopping and pain relieving layer comprises one or several kinds of materials from high molecular polymers, bleeding stopping factors dispersed into the high molecular polymers and pain relieving medicine; the anti-bacterial healing promotion layer comprises high molecular polymers, antibacterial medicine dispersed in the natural high molecular polymers, and mesoporous SiO2 particles loaded with bioactive factors. The preparation method is simple; the materials can be easily obtained; the treatment and the use are safe; the prepared multifunctional ordered medicine release medical coating film can be matched with different stages of the wound healing; the medicine or active substances required for wound healing can be timely and orderly released.
Owner:DONGHUA UNIV
Preparation method of tissue-regeneration-promoting controlled-release multiple-growth-factor self-assembled coating
InactiveCN103751847AIn situ induced activationRegulated releaseProsthesisBiocompatibilityOrganic polymer
The invention belongs to the biological regenerative medicine field, and particularly relates to a preparation method of a tissue-regeneration-promoting controlled-release multiple-growth-factor self-assembled coating. The preparation method is as follows: using an organic polymer membrane and a three-dimensional scaffold as templates, and loading bone morphogenetic protein-2 (BMP2), dentin non-collagenous proteins (DNCPs), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and other bioactive factors with tissue regeneration promotion effects by a supramolecular layer by layer self-assembly technique to form a certain layers of supramolecular biological film coating structure simultaneously embedding with different growth factors on the template surface. The tissue-regeneration-promoting functional coating prepared by the preparation method has good biological compatibility and stability, can improve the surface properties of materials, and can induce tissue regeneration by adjusting the release of the loaded growth factors.
Owner:TONGJI UNIV
Injectable type self-healing hemostatic material as well as preparation method and application thereof
The invention discloses an injectable type self-healing hemostatic material as well as a preparation method and application thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action between the microgel particles or the particles and the macromolecules is physical crosslinking and has reversibility, so the hemostatic material prepared by the method has high injectability, self-healing capability and high mechanical strength, does not need to introduce chemical crosslinking reaction in the injection and solidification process, is different from chemical macromolecules, does not introduce a micromolecular crosslinking agent, has high biocompatibility, can be degraded and absorbed, does not have toxic or side effects, has high safety and makes wide application in the field of biomedicine possible.
Owner:SHENZHEN HUA NOVA BIOTECH LTD
Porous composite biological material containing multiple active ions and preparation method thereof
InactiveCN103520779AImprove conductivityPromote formationCoatingsProsthesisPhosphateBiological materials
The invention discloses a porous composite biological material containing multiple active ions and a preparation method thereof, relating to the technical filed of production of medical materials. The porous composite biological material is a triple compound containing multiple active ions and calcium phosphate-silicate-calcium carbonate, and is composed of a porous ceramic structure main body containing active ions A and calcium phosphate-calcium carbonate and a phosphate-silicate cement coating, wherein both phosphate and silicate in the phosphate-silicate cement coating contain active ions B and calcium; and the phosphate-silicate cement coating accounts for 5-60% (mass percent) of the micropore structure main body. According to the invention, the exquisite three-dimensional intercommunication micropore structure of cuttlebone having extremely high porosity is kept, has excellent bone conductibility and favorable degradability, and can be subjected to stepped degradation; the release of the active ions and beneficial elements can be regulated and controlled; and the overall degradation rate of the material can be regulated according to different new bone formation requirements.
Owner:李亚屏
Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized
InactiveCN108126244AControllable macroporous structureControllable sizeAdditive manufacturing apparatusTissue regenerationBone tissueNano hydroxyapatite
The invention provides a tissue engineering scaffold, a preparation method thereof and a 3D printing ink capable of being directly biologically mineralized. The tissue engineering scaffold comprises ahigh molecular hollow tubular structure, and the surface of the scaffold is uniformly covered with a nano-hydroxyapatite layer with controllable thickness. The tissue engineering scaffold can be widely applied to filling and reconstruction of bone tissues. The preparation method of the tissue engineering scaffold is carried out by virtue of shell-core coaxial spray head 3D printing under bio-safety conditions, and a three-dimensional scaffold stacked by hollow pipes can be efficiently prepared. The scaffold comprises an open macroporous structure and a controllable hollow pipe structure. Compared with straight-through hole scaffolds prepared by virtue of an existing template method, the tissue engineering scaffold has two types of hole structures, and the tubular orientation is controllable. The uniformly-distributed and thickness-controllable nano-hydroxyapatite layer is rapidly mineralized on the surface of a high molecular hollow tubular scaffold, so that the adhesion and multiplication of cells and the osteogenic differentiation can be remarkably improved.
Owner:SHENZHEN UNIV
Preparation method and application of nanopore silicon dioxide xerogel
InactiveCN104340984ARegulated releaseStrongly promote common developmentMaterial nanotechnologySilicaSilicon oxideSilicon dioxide
The invention belongs to the technical field of nanomaterial and medicinal preparations and discloses a preparation method and application of nanopore silicon dioxide xerogel. An amine high polymer (branched polyethyleneimine) serving as a template is introduced into a silicon dioxide inorganic material which is synthesized under mild conditions has nanopores and is at a xerogel state to obtain the nanopore silicon dioxide xerogel. A model medicine propranolole hydrochloride is loaded into the nanopore silicon dioxide xerogel prepared through biomimetic synthesis according to an in-situ medicine carrying method, the release of the medicine is slowed down obviously, the morphology, specific area and pore size of the material are changed in a smart way due to the salvation modification of methyl alcohol and the release of the medicine can be regulated therefore. The preparation method and application of silicon dioxide nanomaterial are widened and a new thought is provided for a sustained and controlled release drug delivery system in pharmaceutics.
Owner:SHENYANG PHARMA UNIVERSITY
Near-infrared light response photodynamic drug controlled release system and preparation method thereof
InactiveCN108969480AImprove responsivenessImprove solubilityEnergy modified materialsPharmaceutical non-active ingredientsIonBiocompatibility Testing
The invention relates to a near-infrared light response photodynamic drug controlled release system and a preparation method thereof. The near-infrared light response photodynamic drug controlled release system and the preparation method thereof can effectively solve the problems that an existing controlled release system is poor in near-infrared response, high in toxic and side effects and poor in controllability. The near-infrared light response photodynamic drug controlled release system and the preparation method thereof is characterized in that succinic acid monoester of a light trigger compound is synthesized and is grafted to biodegradable carboxymethyl chitosan (CMCS) with good biocompatibility so as to form an amphiphilic conjugate, the amphiphilic conjugate is dissolved in neutral or weakly-alkaline deionized water, then an organic solution containing a hydrophobic photodynamic is added, uniform mixing is carried out, and ultrasonic self-assembly is carried out so as to obtain the near-infrared light response photodynamic drug controlled release system. The controlled release system reaches a target part of a human body through intravenous injection or other approaches and can respond to in-vitro near-infrared light stimulation to accelerate release of the photodynamic agent; and the release of the photodynamic agent can be regulated and controlled by adjusting the action time and the intensity of near-infrared light, and the controlled release system is used for photodynamic therapy of cancers.
Owner:WUHAN UNIV OF TECH
Piribedil sustained-release tablet and preparation method thereof
ActiveCN107095855AOvercoming difficulty in regulationGood sustained release effectOrganic active ingredientsNervous disorderWaxPharmaceutical formulation
The invention belongs to the field of pharmaceutical preparations and discloses a piribedil sustained-release tablet and a preparation method thereof. The sustained-release tablet is prepared from, by mass, 10%-40% of piribedil, 50%-80% of a hydrophobic framework material, 1%-5% of an adhesive and 0.5%-5% of a lubricating agent, wherein the hydrophobic framework material is a mixture of microcrystalline cellulose, glyceride, wax and a melting promotion agent, glyceride refers to one or two of glycerin monostearate or glyceryl palmitostearate, and wax refers to one or two of white beeswax or palm wax. The sustained-release tablet which comprises the hydrophobic framework material and the like has advantages of high controllability in medicine release, applicability to treatment of Parkinson's disease, simple process and benefits to production expansion.
Owner:SUZHOU HOMESUN PHARMA
Chitosan coating material with adjustable slow release performance and preparation method thereof
InactiveCN104725142ACannot meet the requirements of slow-release coatingRegulated releaseLayered/coated fertilisersFertilizer mixturesPolymer scienceChitosan coating
The invention discloses a chitosan coating material with adjustable slow release performance and a preparation method thereof. The method comprises the following steps: modifying the chitosan by the alkyl ketene dimers to obtain a hydrophobic chitosan slow release material, reacting the alkyl ketene dimers with active hydroxyl and amino in the chitosan chain and introducing a long-chain hydrophobic gene in the chitosan chain; and mixing a terminated isocyanate cross-linking agent and a modified chitosan derivative to prepare the slow release coating solution. The grafting ratio of the chitosan is different, the hydrophobic ability of the chitosan derivative is different, and the cross-linking degree of the material can be changed according to the dosage of the cross-linking agent, so that the slow release performance of the coating material can be adjusted and the purpose for adapting to different crop growth cycles can be reached.
Owner:HEFEI UNIV OF TECH
Organic inorganic compound flower-like coating and preparation method thereof
ActiveCN109364291AImprove biological activityGuaranteed activityLiquid/solution decomposition chemical coatingTissue regenerationOsteoblastBiocompatibility Testing
The invention relates to the field of surface modification of biological materials and specifically relates to an organic inorganic compound flower-like coating and a preparation method thereof. The preparation method comprises the following steps: soaking a metal substrate in a mixed solution of zinc phosphate solution and biological active organic molecular solution, and then performing liquid deposition for 2.5-4 hours at 36-38 DEG C. A liquid deposition method is adopted for preparing a compound coating on the metal substrate after the zinc phosphate solution and the biological active organic molecular solution are mixed, and on the basis of a chemical coordination principle, organic molecules and inorganic components are compounded and hybridized so as to form a special flower-like topological structure, so that the activity and stability of organic molecules are guaranteed, and meanwhile, the biological activity and biocompatibility of coating are promoted under the synergistic effect of inorganic components, organic active molecules and special flower-like structure, the deposition of active calcium phosphate can be induced and the growth, proliferation and adhesion of osteoblasts can be boosted. Besides, the corrosion degradation rate of zinc substrate can be effectively restrained and the release of zinc ions can be regulated and controlled.
Owner:SOUTHWEST JIAOTONG UNIV
Environmental protection type slow-release fertilizer coating material preparation method
The present invention belongs to the technical field of slow-release fertilizer coating material preparation, and relates to an environmental protection type slow-release fertilizer coating material preparation method, which comprises: taking a natural skim rubber, pre-treating, taking manihot esculenta starch, and modifying to obtain modified starch for spare; and adding the modified starch to the natural skim rubber, rapidly and uniformly mixing, adding a cross-linking agent and a short chain starch activator, and carrying out a reaction to obtain a starch grafted and modified natural skim rubber emulsion, ie., the environmental protection type slow-release fertilizer coating material. According to the present invention, the pre-activation short chain starch emission grafting technology is used, the process is simple, and the reaction is stable; and according to the obtained slow-release fertilizer coating material, the slow-release property of the fertilizer can be regulated, the coating has good toughness and good soil burying degradation property, the high added value utilization of the natural skim rubber is easily achieved, the natural environment protection and the l petrochemical resource saving are easily achieved, and the traditional agriculture is easily converted into the green organic agriculture.
Owner:HAINAN UNIVERSITY
Preparation method of multi-growth-factor slow release coating of titanium and titanium alloy surface
InactiveCN102950102BTight fitIncrease fixed amountLiquid surface applicatorsCoatingsTitanium surfaceNanoparticle
Owner:SOUTHWEST JIAOTONG UNIV
Development and application of cryptotanshinone sustained release solid dispersion pellet
InactiveCN104706598ARegulated releaseHigh porosityOrganic active ingredientsAntipyreticSalvia miltiorrhizaHydrophobic polymer
The invention relates to development and application of a cryptotanshinone sustained release solid dispersion pellet and belongs to the field of medicines. Cryptotanshinone is a salviae miltiorrhizae fat soluble active ingredient, and researches show that cryptotanshinone has obvious anti-inflammatory and antioxidant activities and has an obvious subsidiary function in salviae miltiorrhizae angina treatment, so that the cryptotanshinone sustained release solid dispersion pellet is designed and prepared according to chronopharmacology principles and is applied to treatment on angina. Firstly an appropriate hydrophilic and hydrophobic polymer material is selected as a dispersion carrier, then an appropriate simple and convenient method is utilized for preparing the cryptotanshinone sustained release solid dispersion pellet, and medicine release is regulated by regulating the carrier ratio, so that the medicine release is consistent with attack frequency of the angina.
Owner:CHINA PHARM UNIV
Tumor-immunity-enhancement nutrient food and preparation method thereof
PendingCN110463990AFull of nutritionReasonable structureFood ingredient functionsNutrientInfection complication
The invention discloses a tumor-immunity-enhancement nutrient food and a preparation method thereof. The tumor-immunity-enhancement nutrient food is prepared from, by weight, 5-25 parts of high-quality protein, 5-25 parts of dietary fiber immune nutrients, 29-76 parts of amino acid immune nutrients, 0-2 parts of probiotic immune nutrients, 4-15 parts of an acidity regulator, 3-10 parts of L-malicacid, 0-3 parts of a sweetening agent, 0-2 parts of essence, 0-1 part of a compound nutrition enhancer and 5-15 parts of carbohydrate. The preparation method of the tumor-immunity-enhancement nutrientfood comprises the steps of a) weighing; b) smashing; c) premixing; d) total mixing; e) subpackaging. The food has high target performance, by adding the immune nutrient substances, the nutrient conditions of a tumor patient can be improved, the body immunity and the inflammatory reaction can be regulated, and therefore the effects are achieved that infection and non-infection complications are reduced, the hospitalization time is shortened, and the treatment effect is improved.
Owner:浙江禾健生营养科技有限公司 +1
Photo-thermal anti-tumor and osteogenesis-promoting composite material and preparation method thereof
PendingCN112516382ARegulated releaseExcellent photothermal performanceTissue regenerationCoatingsBone neoplasmPolyphenol
The invention relates to a photo-thermal anti-tumor and osteogenesis-promoting composite material and a preparation method thereof, and particularly discloses photo-thermal anti-tumor bone repair particles. The photo-thermal anti-tumor bone repair particles comprise magnesium micro-nano particles and a poly-polyphenol layer coating the magnesium micro-nano particles. The invention further discloses a photo-thermal anti-tumor bone repair particle-containing composite material. Through the method described by the invention, the magnesium-containing particles with osteogenic activity can be endowed with photo-thermal conversion properties, and the surfaces of the particles contain active functional groups capable of being crosslinked with hydrogel, so that the release of magnesium ions in themagnesium-containing hydrogel composite material is regulated and controlled. According to the method, anti-tumor and osteogenesis promoting components can be prevented from being introduced into a biological material used after bone tumor excision at the same time, and the purposes of photo-thermal anti-tumor and osteogenesis promoting can be achieved by only introducing the poly-polyphenol to modify the magnesium-containing particles.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Method for preparing single crystal or amorphous substance by using aqueous solution
PendingCN110607552AEfficient manufacturingSolving the problem of single crystal preparation of difficult-to-crystallize moleculesFrom normal temperature solutionsSingle crystalWater soluble
Owner:INST OF CHEM CHINESE ACAD OF SCI +1
Preparation method of self restoration antibacterial microcapsule film based on host-guest interaction
ActiveCN108587361AAchieve self-healingAchieving Controlled Drug Release CapabilitiesAntifouling/underwater paintsPaints with biocidesFilm baseFerrocene
The invention discloses a preparation method of a self restoration antibacterial microcapsule film based on host-guest interaction. Firstly, ferrocene (Fc) is successfully modified onto a branch chainof polyacrylic acid (PAA) to form PAA-Fc polymers; then, micro capsules (PAH / PSS) are carried with different concentrations of chloromycetin; through a layer-by-layer self assembly technology, a substrate material is firstly soaked into a PAA-Fc solution for a period of time; after being taken out, the substrate material is flushed by ultrapure water and is then soaked into a beta-cyclodextrin branched polyethylenimine (beta-CD-PEI) solution for a period of time; after being taken out, the substrate material is flushed by ultrapure water and is then soaked into a medicine-carrying microcapsule for a period of time; a multilayer functional nanometer medicine-carrying microcapsule film is repeatedly assembled on the substrate for multiple times. The method has the advantages that convenience is realized; the cost is low; the prepared medicine-carrying microcapsule host-guest film has good self restoration functions, medicine release functions and antibacterial functions.
Owner:南通吉普森科技有限公司
Lurasidone hydrochloride sustained release tablet and preparing method thereof
InactiveCN107998093AGood sustained release effectSimple processOrganic active ingredientsNervous disorderDrugPharmaceutical formulation
The invention belongs to the field of pharmaceutic preparation, and discloses a lurasidone hydrochloride sustained release tablet and a preparing method thereof. The release tablet is prepared from, by mass, 5-15% of lurasidone hydrochloride, 50-90% of hydrophobic skeleton material, 1-5% of adhesive and 0.5-5% of lubricant. The lurasidone hydrochloride sustained release tablet comprises the hydrophobic skeleton material and the like, medicine release can be regulated well, the lurasidone hydrochloride sustained release tablet can be used for treating osteoarthritis, the process is simple, andexpanded production is facilitated.
Owner:佛山市弘泰药物研发有限公司
Method for preparing single crystal or amorphous substance by utilizing solution freezing
PendingCN110735177AEfficient manufacturingSolving the problem of single crystal preparation of difficult-to-crystallize moleculesPolycrystalline material growthFrom normal temperature solutionsHigh concentrationCrystalline materials
The invention relates to the technical field of preparation of single crystals or amorphous substances, in particular to a method for preparing a quasi-crystalline substance single crystal or an amorphous substance. According to the method, nucleation and crystallization of the quasi-crystalline substance are induced through solution freezing, crystallization of the dissolved quasi-crystalline substance is achieved in the freezing process of the solution, and single crystals or amorphous substances of the quasi-crystalline substance are rapidly and effectively prepared. Meanwhile, the problemthat single crystals or amorphous substances of molecules are difficult to crystallize in traditional pseudo-crystalline substance single crystal preparation and culture is solved. According to the method, the acquisition of the pseudo-crystalline substance single crystal or amorphous substance under extremely low solution concentration is realized for the first time; and the problems of difficultcontrol of single crystal formation, easy formation of polycrystals and twin crystals and the like caused by too fast aggregation of quasi-crystalline substances under high concentration are also solved. The method is wide in application range and suitable for existing quasi-crystalline substances.
Owner:INST OF CHEM CHINESE ACAD OF SCI +1
A kind of preparation method of in-situ reaction film-forming pore-type controlled-release fertilizer
ActiveCN104447027BRegulated releaseShorten the period of fertilizationLayered/coated fertilisersFertilizer mixturesPorosityVegetable oil
The invention discloses a hole-forming controlled-release method of enveloped controlled-release fertilizers and a preparation method of the in-situ reaction film-forming and hole-forming type controlled-release fertilizers. The preparation method comprises the following steps: adding different types of hole-forming materials into vegetable-oil polyol, preparing to obtain a coating material of the vegetable-oil polyol containing a hole forming agent, by adopting two types of materials such as the vegetable-oil polyol containing the hole forming agent and polyisocyanate as skeleton materials, spraying the two types of materials onto the surfaces of the fertilizers in a fluidized bed by an in-situ reaction film-forming technology, carrying out in-site reaction, thus forming a coating film and preparing the in-situ reaction film-forming and hole-forming type controlled-release fertilizers. The preparation method disclosed by the invention has the advantages that the permeability of the coating layer of the fertilizers can be controlled, the hole-diameter size, the porosity, the moisture permeability and the water absorption rate and the like on the thin-film layer can be changed and the purpose of controlling the nutrient release can be realized; the hole forming agent has no influence on the coating integrity of the controlled-release fertilizers, the nutrient release mode of the coated controlled-release fertilizers can be changed, and the fertilizer effect period of the coated fertilizers can be shortened, so that the nutrient release of the controlled-release fertilizers and the nutrient need for crops can be well combined.
Owner:SOUTH CHINA AGRI UNIV
A kind of preparation method and application of nanoporous silica xerogel
InactiveCN104340984BRegulated releaseStrongly promote common developmentMaterial nanotechnologySilicaSilicon oxideDelivery system
The invention belongs to the technical field of nanomaterial and medicinal preparations and discloses a preparation method and application of nanopore silicon dioxide xerogel. An amine high polymer (branched polyethyleneimine) serving as a template is introduced into a silicon dioxide inorganic material which is synthesized under mild conditions has nanopores and is at a xerogel state to obtain the nanopore silicon dioxide xerogel. A model medicine propranolole hydrochloride is loaded into the nanopore silicon dioxide xerogel prepared through biomimetic synthesis according to an in-situ medicine carrying method, the release of the medicine is slowed down obviously, the morphology, specific area and pore size of the material are changed in a smart way due to the salvation modification of methyl alcohol and the release of the medicine can be regulated therefore. The preparation method and application of silicon dioxide nanomaterial are widened and a new thought is provided for a sustained and controlled release drug delivery system in pharmaceutics.
Owner:SHENYANG PHARMA UNIVERSITY
Development and application of a cryptotanshinone sustained-release solid dispersion pellet
InactiveCN104706598BRegulated releaseHigh porosityOrganic active ingredientsAntipyreticSalvia miltiorrhizaHydrophobic polymer
The invention relates to development and application of a cryptotanshinone sustained release solid dispersion pellet and belongs to the field of medicines. Cryptotanshinone is a salviae miltiorrhizae fat soluble active ingredient, and researches show that cryptotanshinone has obvious anti-inflammatory and antioxidant activities and has an obvious subsidiary function in salviae miltiorrhizae angina treatment, so that the cryptotanshinone sustained release solid dispersion pellet is designed and prepared according to chronopharmacology principles and is applied to treatment on angina. Firstly an appropriate hydrophilic and hydrophobic polymer material is selected as a dispersion carrier, then an appropriate simple and convenient method is utilized for preparing the cryptotanshinone sustained release solid dispersion pellet, and medicine release is regulated by regulating the carrier ratio, so that the medicine release is consistent with attack frequency of the angina.
Owner:CHINA PHARM UNIV
In vitro release and antioxidant properties of loaded apigenin based on the construction of tween 80 biocompatible microemulsion
ActiveCN108113964BImprove solubilityGood sustained releaseOrganic active ingredientsAntinoxious agentsActive agentApigetrin
The invention relates to construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin. A pseudo-ternary phase diagram is adopted for constructing Tween80 / IPM / PEG400 / H2O biocompatible microemulsion, and partition is carried out by utilizing conductivity, so that structure of the microemulsion is changed from a bicontinuous phase(B.C.) to an O / W type. Further the O / W type microemulsion is selected as an apigenin carrier, saturation solubility experiments show that the constructed microemulsion obviously improves solubility ofthe apigenin, and compared with the solubility in water, the solubility is improved by 300 times when the microemulsion is taken as the carrier. In vitro release experiments show that the microemulsion has better slow-release effect on the apigenin, and a releasing process of the apigenin in the microemulsion accords with first-order kinetics and is under concentration diffusion control. A medicine still has better antioxidant activity in the microemulsion and has better clearing effect on ABTS<+>.. Release rate of the apigenin in the microemulsion, accumulated release rate and antioxidant activity can be regulated and controlled by changing a mass ratio of a surfactant to oil (S / O) and water content.
Owner:海生健康科技(青岛)有限公司
Method for preparing nanosilver/silicon dioxide composite structure coating through pulsed laser deposition
InactiveCN103540899BSimple to use ingredientsShort generation cycleVacuum evaporation coatingSputtering coatingOxygenSilicon dioxide
The invention relates to a method for preparing nanosilver / silicon dioxide composite structure coating through pulsed laser deposition. The method aims at solving the problems that the existing method for preparing a nanosilver / silicon dioxide composite structure has various chemical raw materials and causes impurities in the reaction process. The preparation method comprises the steps of I, preparing a silver / silicon dioxide composite target material; II, cleaning a substrate; III, respectively fixing the target material and the substrate on a self-rotation target position and a sample holder; IV, leading in oxygen after vacuumizing; V, performing laser ablation to deposit a coating at room temperature by adopting an excimer laser; VI, stopping deposition. For the nanosilver / silicon dioxide composite structure coating prepared by adopting the method, only two raw materials are used, the introduction of impurities can be avoided as preparation is performed in a vacuum cavity, the use of the substrate made of different inorganic, organic material and the like can be guaranteed due to room-temperature deposition, the nanosilver / silicon dioxide composite structure coating is potentially widely applied in the fields of medicinal, electronic and other fields; the method is used for preparing the nanosilver / silicon dioxide composite structure coating.
Owner:HARBIN INST OF TECH
Injectable self-healing gel that can be used for drug loading and release, its preparation method and application
ActiveCN107007881BImprove liquidityGood injectabilityAdditive manufacturing apparatusPharmaceutical delivery mechanismMedicinePharmaceutical drug
Owner:SHENZHEN HUA NOVA BIOTECH LTD
Dronedarone hydrochloride slow-release tablets and preparation method thereof
InactiveCN108014082ASimple processGood sustained release effectOrganic active ingredientsPill deliveryExtended release tabletsDronedarone hydrochloride
The invention belongs to the field of medicine preparations and discloses dronedarone hydrochloride slow-release tablets and a preparation method thereof. The slow-release tablets are prepared from, in percentage by mass, 10%-35% of dronedarone hydrochloride, 50%-90% of a hydrophobic framework material, 1%-5% of a binder and 0.5%-5% of a lubricant. The slow-release tables are prepared from the hydrophobic framework material and the like, medicine release can be well controlled, the process is simple, and expanded production is facilitated.
Owner:佛山市弘泰药物研发有限公司
A kind of injectable self-healing hemostatic material and its preparation method and application
ActiveCN106983905BGood coagulationHemostasis achievedSurgical adhesivesGreat Blood VesselBiocompatibility
Provided are a hemostatic material, a preparation method thereof and a use thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action is physical crosslinking and has reversibility, and no micromolecular crosslinking agent is introduced during the injecting and curing process, so the obtained hemostatic material has good mechanical strength, and can achieve rapid hemostasis for bleeding tissue with large bleeding volume and high blood pressure.
Owner:SHENZHEN HUA NOVA BIOTECH LTD
A preparation method of self-healing antibacterial microcapsule film based on host-guest interaction
ActiveCN108587361BAchieve self-healingAchieving Controlled Drug Release CapabilitiesAntifouling/underwater paintsPaints with biocidesFerroceneEngineering
Owner:南通吉普森科技有限公司
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