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A kind of preparation method and application of nanoporous silica xerogel

A technology of silica and nanopores, applied in the direction of silica, silica, nanotechnology, etc., can solve the problems of limited silica xerogel in-depth research and application

Inactive Publication Date: 2016-04-27
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation methods of silica xerogels use acid solution as a catalyst, without introducing templates to regulate the shape and structure of materials, which limits the in-depth research and application of silica xerogels to a certain extent.

Method used

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  • A kind of preparation method and application of nanoporous silica xerogel
  • A kind of preparation method and application of nanoporous silica xerogel
  • A kind of preparation method and application of nanoporous silica xerogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Biomimetic Synthesis of Nanoporous Silica Xerogels

[0024] Aqueous coagulant prescription for PEIs:

[0025] PEIs0.4ml

[0026] Water 40.8ml

[0027] Sol solution prescription:

[0028] Aqueous coagulant of PEIs 1.0ml

[0029] TMOS1.0ml

[0030] Absolute ethanol 1.0ml

[0031] Preparation Process:

[0032] A, the preparation of the aqueous coagulation solution of PEIs:

[0033] The prescribed amount of PEIs was dissolved in the prescribed amount of water, so that the mass fraction of the obtained template solution was 1.0%. Seal the template solution and let it stand for 24 hours at room temperature to obtain template aqueous condensate.

[0034] B. Preparation of biomimetic synthesized nanoporous silica gel:

[0035] Add the prescription amount of PEIs aqueous coagulation solution into 2ml of TMOS and absolute ethanol mixed solution to obtain the reaction sol. Seal the reaction sol at room temperature until a light blue nanoporous silica gel i...

Embodiment 2

[0044] Preparation of Nanoporous Silica Xerogel Modified with 25% (v / v) Methanol

[0045] 25% Methanol Aqueous Coagulant Prescription for PEIs:

[0046] PEIs0.4ml

[0047] Water 157.5ml

[0048] Methanol 52.5ml

[0049] Sol solution prescription:

[0050] PEIs 25% methanol aqueous coagulation solution 1.0ml

[0051] TMOS1.0ml

[0052] Absolute ethanol 1.0ml

[0053] Preparation Process:

[0054] A, the preparation of the 25% aqueous methanol coagulant of PEIs:

[0055] The prescribed amount of PEIs was dissolved in the prescribed amount of methanol and water, so that the mass fraction of the obtained template solution was 1.0%. Seal the template solution and let it stand for 24 hours at room temperature to obtain a 25% aqueous methanol condensate of the template.

[0056] B. Preparation of nanoporous silica gel modified with 25% methanol:

[0057] Add the prescribed amount of PEIs coagulation solution to 2ml of TMOS-dehydrated ethanol mixed solution to obtain the rea...

Embodiment 3

[0063] Preparation of Nanoporous Silica Xerogel Modified with 75% (v / v) Methanol

[0064] 75% Methanol Aqueous Coagulant Prescription for PEIs:

[0065] PEIs0.4ml

[0066] Water 17.5ml

[0067] Methanol 52.5ml

[0068] Sol solution prescription:

[0069] PEIs 75% methanol aqueous coagulation liquid 1.0ml

[0070] TMOS1.0ml

[0071] Absolute ethanol 1.0ml

[0072] Preparation Process:

[0073] A, the preparation of the 75% aqueous methanol coagulant of PEIs:

[0074] The prescribed amount of PEIs was dissolved in the prescribed amount of methanol and water, so that the mass fraction of the obtained template solution was 1.0%. Seal and let the template solution stand at room temperature for 24 hours to obtain a 75% aqueous methanol condensate of the template.

[0075] B. Preparation of nanoporous silica gel modified with 75% methanol:

[0076] Add the prescribed amount of PEIs coagulation solution into 2ml of TMOS-dehydrated ethanol mixture to obtain a reaction sol. S...

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Abstract

The invention belongs to the technical field of nanomaterial and medicinal preparations and discloses a preparation method and application of nanopore silicon dioxide xerogel. An amine high polymer (branched polyethyleneimine) serving as a template is introduced into a silicon dioxide inorganic material which is synthesized under mild conditions has nanopores and is at a xerogel state to obtain the nanopore silicon dioxide xerogel. A model medicine propranolole hydrochloride is loaded into the nanopore silicon dioxide xerogel prepared through biomimetic synthesis according to an in-situ medicine carrying method, the release of the medicine is slowed down obviously, the morphology, specific area and pore size of the material are changed in a smart way due to the salvation modification of methyl alcohol and the release of the medicine can be regulated therefore. The preparation method and application of silicon dioxide nanomaterial are widened and a new thought is provided for a sustained and controlled release drug delivery system in pharmaceutics.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and pharmaceutical preparations, and relates to a preparation method of nanoporous silica xerogel and its application in a sustained and controlled release drug delivery system. Background technique [0002] Inspired by the cell wall of marine eukaryotic diatoms and spongy spicules of sponges, which can present delicate silica structures, people use active molecules extracted from organisms (such as silicatein), synthetic amine molecules or macromolecules, and Peptides and proteins, biomimetic synthesis of silica under mild conditions. This biomimetic synthesis process has two unique advantages compared with general methods of synthesizing silica (such as gas phase method, sol-gel method, precipitation method, inverse microemulsion method, etc.): First, the biomimetic synthesis process does not require high temperature , high pressure and extreme pH, is a green synthetic route; s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/16A61K47/04B82Y30/00
Inventor 李三鸣徐璐李静
Owner SHENYANG PHARMA UNIVERSITY
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