A kind of injectable self-healing hemostatic material and its preparation method and application

Abstract

Provided are a hemostatic material, a preparation method thereof and a use thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action is physical crosslinking and has reversibility, and no micromolecular crosslinking agent is introduced during the injecting and curing process, so the obtained hemostatic material has good mechanical strength, and can achieve rapid hemostasis for bleeding tissue with large bleeding volume and high blood pressure.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a hemostatic material and a preparation method thereof. Specifically, the invention relates to a hemostatic material that can be directly applied to human and other breastfeeding patients caused by surgical operations (including minimally invasive operations) and trauma. The preparation method of gelatin-based hemostatic powder and hemostatic gel material for the purposes of hemostasis, wound sealing, tissue exudation reduction, tissue repair promotion and wound tissue protection for tissue and organ wounds of animals. Background technique [0002] During surgical operations, it is necessary to stop bleeding and seal wounds caused by different reasons. Therefore, hemostatic materials are a very important class of biomedical materials, which have important research and application significance. At present, the hemostatic materials commonly used in clinical practice can ...

AI Technical Summary

Problems solved by technology

[0004] However, hemostatic products that achieve hemostasis through physical action, such as hemostatic gauze, sponge, etc., need to physically compress the bleeding wound during the hemostatic process, and at the same time, the material absorbs water in the blood to promote coagulation, and the hemostatic speed is slow and the effect is poor.

Moreover, this type of material is only effective for bleeding with a small flow rate, so it must be used with a hemostatic clamp, which makes the above-mentioned hemostatic material often require the surgeon to predict the amount of bleeding in advance or repeatedly use the hemostatic forceps

At the same time, traditional hemostatic materials (such as cotton gauze, bandages) are not ideal for the hemostatic effect of common wounds such as irregular shapes, deep, narrow, ruptured arteries, etc.

In addition, there are other disadvantages: 1) It affects postoperative suture and increases new wound bleeding; 2) It cannot be degraded naturally, and residues are formed in the body; 3) The process of hemostasis requires long-term external pressure to achieve physical hemostasis, which is difficult for fragile nerves. or brain tissue does not apply

First, the mechanical strength of the gel is poor, and the elastic modulus measured by the rheometer is less than 1kPa, so hemostasis cannot be achieved for bleeding tissues with large bleeding volume and high vascular pressure; It is difficult to achieve rapid hemostasis on the wound surface

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