The invention provides a
dronedarone hydrochloride pharmaceutical composition which is suitable for the
sublingual administration, can quickly run, and can greatly improve the
bioavailability and the
curative effect. The pharmaceutical composition consists of 5-65 parts of
dronedarone hydrochloride, 1-10 parts of a disintegrating agent, 10-80 parts of filler, 0.5-3 parts of
antacid, 0-5 parts of corrigent, 1-10 parts of an
adhesive and 0.3-2 parts of a lubricating agent. The invention further provides a preparation method suitable for the industrial production. The
dronedarone hydrochloride pharmaceutical composition provided by the invention is directly absorbed by the sublingual mucosa, and the first-pass effect of oral medicaments can be avoided, and the
gastrointestinal digestion, acidolysis and the like can be avoided, so that the
bioavailability can be greatly improved. The
epithelium of the sublingual mucosa is not cornified, so that the
dronedarone hydrochloride pharmaceutical composition is large in superficial area, and high in infiltration capacity. The medicament can be quickly absorbed after being administrated, so that the
dronedarone hydrochloride pharmaceutical composition is quick to run, and convenient to use; and compared with the other administrated preparations, the
dronedarone hydrochloride pharmaceutical composition is convenient to administrate, and good
in patient compliance.