34 results about "Bone neoplasm" patented technology

The invention provides a method of correcting numerous bone abnormalities including bone tumors and cysts, avascular necrosis of the femoral head, tibial plateau fractures and compression fractures of the spine. The abnormality may be corrected by first accessing and boring into the damaged tissue or bone and reaming out the damaged and / or diseased area using any of the presently accepted procedures or the damaged area may be prepared by expanding a bag within the damaged bone to compact cancellous bone. After removal and / or compaction of the damaged tissue the bone must be stabilized.

The invention relates to a non-coplanar radiotherapy system in the field of medical equipment, which comprises a radiation source, a frame, an image positioning system and a therapeutic bed. The frame is composed of a revolution base, an L-shaped rotation arm and a C-shaped rotation arm. The revolution base and the L-shaped rotation arm are connected via a revolute pair. The L-shaped rotation arm and the C-shaped rotation arm are connected via a second revolute pair. The radiation source is arranged at one end of the C-shaped rotation arm. The other end of the C-shaped rotation arm is provided with a dosimetric verification device. The image positioning system is composed of two sets of X-ray image systems. The two sets of X-ray image systems are arranged on the two sides of the C-shaped rotation arm in the crossed manner. The therapeutic bed is installed corresponding to the frame, and is composed of a therapeutic bed plate, a slipway and a therapeutic bed support mechanism. The therapeutic bed plate and the slipway are connected via a third revolute pair. The non-coplanar radiotherapy system can be used for the coplanar radiotherapy and the non-coplanar radiotherapy of head and neck neoplasms, bone neoplasms, spinal neoplasms and the like. Meanwhile, the frame is large in motion range and high in flexibility.

The invention relates to a method for preparing a medical titanium material with high anti-cancer and antibacterial properties. The method comprises the following steps of: firstly, generating highly regular and ordered titanium dioxide nanotube arrays on the surface of the titanium material by an anodic oxidation method; secondly, generating selenium nanoparticles in titanium dioxide nanotubes in situ by an electrochemical deposition method; and finally, modifying multi-layer chitosan on the surface of the titanium material by a spin-coating method to obtain the medical titanium material with high anti-cancer and antibacterial properties. The method is easy to operate and low in cost, special equipment is not needed, and tests prove that the obtained product can inhibit the growth of bone tumor cells for a long time and promote the growth of normal osteoblasts simultaneously and has high antibacterial property.

The invention discloses a device used for preventing tumor spreading after bone neoplasms biopsy, belonging to the technological field of medical instruments, which comprises a plugging body used for plugging biopsy needle passage after biopsy is made; wherein, the plugging body is made of water absorbing expandable material; a plurality of screw threads are arranged at outer surface; one end of the plugging body is plugging end; the maximum diameter of the plugging end is smaller than the diameter of the biopsy needle passage; the other end of the plugging body is an operation end; a jack or an inserting handle grafting the operation wrench along axial direction of the plugging body is arranged on the operation end; maximum diameter of the operation end is bigger than the diameter of the biopsy needle passage; central section of the plugging body is inner concave type connection rod; smooth transition is adopted between the connection rod and the plugging end and the operation end; an anti-cancer drug layer is coated on the plugging end and is used for plugging the needle passage after biopsy is made. The device used for preventing tumor spreading has the advantages of preventing tumor from flowing out from the needle passage to the peripheral of puncturing site and from causing locally spreading and metastasizing, having simple structure and convenient operation.

The invention discloses a device for preventing tumor spread after bone tumor biopsy, and belongs to the technical field of medical apparatuses. The device comprises a puncture needle, a sleeve and asampling needle; a sampling coil is fixedly connected to the outer wall of the sampling needle, multiple sampling scraping barbs are fixedly connected to the side wall of the sampling coil, a temporary storage cavity is formed in the sampling needle and located at the bottom of the sampling coil, and the puncture needle sleeves the outer wall of the sampling needle. A sealing platform is fixedly connected to the top of the puncture needle, a liquid injection channel is formed in the middle of the sealing platform, a rubber ring is fixedly connected to the end of the liquid injection channel, asealing gasket is fixedly installed at the junction of the sampling needle and the puncture needle, a sleeve sleeves the outer wall of the puncture needle, a positioning device is fixedly connected to the top of the sleeve, a push needle is matched in an inner cavity of the puncture needle, a fixed needle is fixedly connected to the end of the push needle, and a plug sleeves the outer wall of thefixed needle. By means of the device, the puncture depth is conveniently controlled. Examination tissue cannot shed or get lost, and the puncture success rate is increased. The plug absorbs drugs toplug a puncture channel, a needle passage is subjected to bleeding stopping, and tumor spread is prevented.

The invention discloses a 3D printed magnetic biological ceramic scaffold which is prepared by taking biological ceramic powder, magnetic nano powder and a printing aid as main raw materials and sequentially carrying out 3D printing and degreasing sintering according to a three-dimensional scaffold model. According to the invention, a 3D printing technology is adopted, a magnetic nano material isfurther introduced into a biological ceramic material system by combining a liquid drying method and a two-step sintering method, so that the3D printed magnetic biological ceramic scaffold is endowedwith a magnetic effect which is not possessed by a traditional biological ceramic scaffold, the shape control and on-demand customization of the biological ceramic scaffold can be realized, and the biological ceramic scaffold is expected to be used for treating bone tumors and repairing bone defects; and the related preparation method is simple, wide in material source and suitable for popularization and application.

The invention discloses an adjustable bone tumor pathological specimen sampling fixator which comprises a workbench, a rotating shaft and a worm gear, a guide block is slidably mounted in a first sliding groove, a mounting frame is fixedly mounted at the top end of a supporting frame, and a first worm and a second worm are rotatably mounted between the mounting frame and the workbench. One end of the first worm and one end of the second worm are in transmission connection with the output end of a first motor and the output end of a second motor respectively, the two ends of the worm gear are in meshing transmission with the first worm and the second worm respectively, one end of the rotating shaft is fixedly installed in the worm gear, and the middle of the rotating shaft is rotationally connected with the guide block. A rotating frame is fixedly installed at the end, away from the worm gear, of the rotating shaft, and a movable clamping mechanism is installed in the rotating frame. Through meshing transmission cooperation of the first worm and the second worm with the worm gear, a clamped bone specimen can be lifted and rotated, and pathological specimen sampling can be conveniently carried out on different positions of the bone specimen.

The invention discloses a device for preventing tumor progression after bone tumor biopsy. The device comprises a T-shaped plugging device which is integrally formed by a plugging head and a base, wherein the plugging head is wrapped by a layer of titanium alloy self-tapping threads; a through hole is formed between the top of the base and the bottom of the plugging head; a plugging rod with a straight line or cross shaped groove in the top and for plugging the through hole is in threaded connection with the through hole; a U-shaped hole is formed in the bottom of the plugging rod; a layer of absorbable medical membrane wraps the bottom of the U-shaped hole. With the combination of a bone substitute material and a titanium alloy, a pore channel or a needle channel left after bone tumor puncture can be permanently and tightly plugged, anti-tumor medicines can be put into the U-shaped hole in advance, and once the pore channel or the needle channel is plugged, the anti-tumor medicines can be dissolved within a certain time by using the absorbable medical membrane and has the lasting treatment effect within a partial plugged area.

The invention relates to the technical field of biomedical materials, in particular to a nano hydroxyapatite-coated porous stent and a preparation method and application thereof. The nano hydroxyapatite-coated porous stent provided herein includes a 3D printing porous titanium matrix material and nano hydroxyapatite coating; a microporous network TiO2 layer is formed on the surface of the 3D printing porous titanium matrix material; the nano hydroxyapatite coating is distributed evenly on the surface of the microporous network TiO2 layer. The invention also discloses a preparation method of the nano hydroxyapatite-coated porous stent and application of thereof in the preparation of bone neoplasm surgery defect repair materials. The nano hydroxyapatite-coated porous stent provided herein has good osteogenic effect, can inhibit the growth of local residual neoplasm cells and reduce recurrence, and has a good clinical application prospect.

The invention discloses a bionic repair method for bone tumors, and belongs to the computer-aided biomedical engineering, and the method comprises the steps: carrying out segmentation with semantic characteristics on tumor image data of a patient, accurately segmenting and extracting an area corresponding to a target bone tissue, and realizing accurate reconstruction of a segmentation result basedon an envelope and approximation bone surface model three-dimensional reconstruction algorithm; constructing a bionic constraint set and a recovery framework for bone loss caused by bone tumors according to biomedical characteristics of a bone system, realizing accurate recovery of a bone loss form, and designing a constrained free form internal fixation prosthesis based on a bone loss form recovery result; designing an internal bionic porous scaffold structure with good mechanical property and machinability according to the information characteristics of the classified bone area and in combination with a skeleton kinematic mechanical analysis result; and finally, generating an integrated implant prosthesis through fusion, so that a personalized and accurate bone tumor repair system is realized.

The invention relates to the technical field of medical instruments, in particular to a bone tumor pathological tissues extractor with a cutting device. The extractor comprises an extractor body. The extractor body comprises a needle and a T-shaped handle. A top end of the needle is provided with a circular connecting block. The middle of the circular connecting block is provided with an inner tube holder. The needle is in a cavity form. A bottom end of the needle is a tip end which is provided with a circular hole. A suction inner tube is arranged in the needle. A bottom end orifice of the suction inner tube is connected with the circular hole. An upper end orifice of the suction inner tube is connected with the inner tube holder in the middle of the circular connecting block. The inner tube having a suction function is arranged in the needle, the cutting device is arranged on the lower portion of one side of the needle, and thus a tissue sample and sample liquid are acquired at a time. The extractor is simple in structure and convenient to operate, acquisition speed is high, work efficiency is high, and pain of a patient is greatly relieved.

The invention relates to injectable composite bone cement with photothermal effect as well as a preparation method and application of the injectable composite bone cement. The injectable composite bone cement is prepared from the following components in percentage by weight: 30 to 65 percent of bioglass powder, 5 to 30 percent of titanium nitride nano powder and 30 to 40 percent of a sodium alginate mixed solution. Compared with the prior art, the bone cement disclosed by the invention not only has the characteristics of being moldable and easy to operate, but also has a remarkable photothermal effect, and the photothermal effect of the bone cement can be regulated and controlled by changing the adding amount of the titanium nitride nanoparticles; process equipment for preparing the bone cement is simple, easy to operate and low in cost, good injectability can be obtained without adding a cross-linking agent, and minimally invasive treatment can be realized; the injectable composite bone cement can be used for preparing bone fillers after bone tumor surgical resection, and is applied to the fields of bone repair, regeneration and the like in bone tissue engineering.

The invention provides a preparation method for a composite photothermal material. The method comprises the following steps: adding potassium hexachloroplatinate solution to G4.5-COONa solution (pH=2), regulating a pH value to be 9.16, after reacting for 12 h in a dark place, adding sodium borohydride solution, after the reaction, dialyzing in a dialysis bag of which a cut-off molecular weight is3500 Da, to obtain the composite photothermal material (DEPt-COOH). A polyamide-amine tree-form macromolecule of which an end group is a carboxyl is used as a carrier, and metal nano photothermal particles are coated in the interior to synthesize a novel compound (DEPt-COOH) which is used for a therapy research of bone tumor. In the multi-functional compound, a poly carboxyl terminal is efficiently chelated with the surface of a corrosion bone so as to realize efficient targeted delivery of the composite material in a bone tumor focal area. Efficient killing to the bone tumor is realized through photothermal therapy, and side effects to a normal tissue are greatly reduced.

The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

The invention discloses a minimally invasive channel bone tumor biopsy device, relates to the technical field of medical instruments, and solves the problems that the minimally invasive channel bone tumor biopsy device can only observe in one direction during use, a biopsy position cannot be positioned well, and the detection precision and biopsy quality will be affected. The minimally invasive channel bone tumor biopsy device comprises a mounting arm; the left arc of the mounting arm is slidably connected with a group of rotary mounting seats; the front end face of the left side of the mounting arm is fixedly connected with a set of angle adjusting driving pieces. the left portion and the lower portion of the inner side of the rotary mounting seats are respectively rotationally connected with a set of transmitting assemblies. According to the invention, imaging in two directions is achieved, meanwhile, by adjusting the installation angle of the rotary mounting seats, observation and imaging are conducted on the diseased part at different angles, the bone tumor biopsy position can be better determined, biopsy quality is guaranteed, detection accuracy is improved, unfolding and folding of the receiving assembly and the transmitting assembly can be achieved, and installation and use are convenient.

The invention discloses a bionic repair system for bone tumors and belongs to the field of computer-aided biomedical engineering and the system comprises a bone tumor image data input unit, a bone tissue region segmentation and surface morphology reconstruction unit, a bone tumor curved surface model unit, an integrated restoration prosthesis design unit and a bionic multi-cavity integrated restoration prosthesis output unit. Wherein the bone tissue region segmentation and surface morphology reconstruction unit comprises a supervoxel division subunit, a statistical machine learning segmentation subunit and a bone curved surface model reconstruction subunit; The integrated restoration prosthesis design unit comprises a bone loss form restoration subunit, an internal structure design subunitand an internal fixation prosthesis design subunit; According to the personalized and precise bone tumor repair system constructed by the invention, the automation of the design process is improved,and the complexity and inconvenience of the design process are reduced, so that the final repair prosthesis has good biocompatibility and mechanical property.

The invention relates to the technical field of biopsy devices, and concretely relates to a safe bone tumor biopsy device. The device comprises a mounting box, a rectangular fixing column is vertically arranged on the surface of the mounting box, a rectangular sliding groove is formed in one side of the rectangular fixing column, a cylindrical mounting bin is formed in the rectangular fixing column, a second spring is arranged in the cylindrical mounting bin, a fixing block is arranged on the other side of the rectangular fixing column and located on the lower middle portion, a locking block is slidably connected to the side face of the fixing block, and a sampling puncture needle body is movably connected to the side face of the rectangular fixing column. The position needing to be sampled is determined through a positioning table, the sampling puncture needle body is inserted into the body of a patient to sample, a pathological specimen can be obtained through a sampling area, a mixture of polyvinyl alcohol and hydrogel in the embolism storage bin is sprayed out from an instantaneous release ring through a micro water pump to timely block a needle hole, and the sampling punctureneedle is thin to avoid the problem of a large incision.

The invention relates to a photo-thermal anti-tumor and osteogenesis-promoting composite material and a preparation method thereof, and particularly discloses photo-thermal anti-tumor bone repair particles. The photo-thermal anti-tumor bone repair particles comprise magnesium micro-nano particles and a poly-polyphenol layer coating the magnesium micro-nano particles. The invention further discloses a photo-thermal anti-tumor bone repair particle-containing composite material. Through the method described by the invention, the magnesium-containing particles with osteogenic activity can be endowed with photo-thermal conversion properties, and the surfaces of the particles contain active functional groups capable of being crosslinked with hydrogel, so that the release of magnesium ions in themagnesium-containing hydrogel composite material is regulated and controlled. According to the method, anti-tumor and osteogenesis promoting components can be prevented from being introduced into a biological material used after bone tumor excision at the same time, and the purposes of photo-thermal anti-tumor and osteogenesis promoting can be achieved by only introducing the poly-polyphenol to modify the magnesium-containing particles.

The invention discloses a device for preventing tumor spread after bone tumor biopsy. The device of the invention comprises an operation tube, a connecting tube, a blocking rod and a puncture tube, wherein the puncture tube is in threaded connection below the operation tube; the connecting tube is arranged between a blocking tube and the operation tube; and the puncture tube is used for puncturingtumor tissues, and a biopsy needle extends from the upper end of the blocking rod for sampling during biopsy. Since various parts are tightly connected and tumors can be blocked in all direction, thedevice for preventing tumor spread after bone tumor biopsy has a good anti-spread effect.

The invention discloses a bone tumor sampling and fixing device, which comprises a workbench; and two supporting columns are symmetrically arranged at the two ends of the surface of the top of the workbench. The top ends of the two supporting columns are connected with arc-shaped bases, the top end of each arc-shaped base is rotationally connected with a circular ring, a plurality of column casings are connected to the inner wall of each circular ring at equal intervals in a surrounding mode, a rack plate is connected to the inner wall of each column casing, and a steel column is arranged in each column casing. First driving motors are started to work at the same time; the first driving motors drive the first driving wheels to rotate; the first driving wheels drive first driven wheels to rotate through belts; the first driven wheels and the first driving wheels drive the worm wheels to rotate through worms, so that the worm wheels are engaged with the rack plates to rotate, the steel columns can move inwards until a bone to be sampled is completely fixed and clamped, and the situation that the bone is loosened in the process of sampling the bone to be sampled can be prevented.

The invention relates to the technical field of biomedical materials, in particular to a nano-hydroxyapatite-coated porous titanium bracket and a preparation method and application thereof. The nano-hydroxyapatite-coated porous titanium stent provided by the present invention includes a 3D printed porous titanium base material and a nano-hydroxyapatite coating; the surface of the 3D printed porous titanium base material forms a microporous network TiO 2 layer; the nano-hydroxyapatite coating is uniformly distributed in the microporous network TiO 2 layer surface. The invention also discloses a preparation method of the nano-hydroxyapatite-coated porous titanium bracket and its application in the preparation of bone tumor operation defect repair materials. The nano-hydroxyapatite-coated porous titanium scaffold provided by the present invention not only has a good osteogenic effect, but also can inhibit the growth of local residual tumor cells and reduce recurrence, showing good clinical application prospects.

The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

A bone tumor biopsy puncture auxiliary device effectively increases the function of determining the knife feeding direction of a puncture needle and a scalpel and comprises a frame, a first rotating frame is arranged on the left side of the frame, a second rotating frame is arranged on the right side of the frame, a positioning box is arranged in the frame, and a positioning gooseneck pipe is arranged on the upper side of the positioning box. Fixed gooseneck pipes are arranged on the left side and the right side of a positioning gooseneck pipe, a fixing mechanism is arranged on the upper sides of the fixed gooseneck pipes, a positioning frame is arranged on the upper side of the positioning gooseneck pipe, a fixing frame is arranged on the front side of the positioning frame, a positioning disc is arranged in the fixing frame, a rotating positioning disc is arranged in the positioning disc, and a needle passage positioning disc is arranged in the rotating positioning disc. The fixing device is simple in structure and ingenious in conception, the aim of fixing limbs of a patient is effectively achieved through the design, the risk of local diffusion of cancer cells is reduced, the aim of positioning and fixing a needle passage is achieved, the function of protecting the puncture position of the patient is added, and the function of color contrast is added.

The invention relates to the technical field of specimen sampling, in particular to a bone tumor specimen sampler which comprises a device body. The device body comprises a first mounting frame, a supporting plate is fixedly mounted at the top of the first mounting frame, and an electric push rod is integrally mounted at the bottom end of the supporting plate. A second mounting frame is integrally mounted at the bottom end of the electric push rod, a motor is fixedly mounted on one side of the bottom end of the second mounting frame, a rotating rod is fixedly connected to the output end of the motor, the end, away from the motor, of the rotating rod is rotationally connected with the other side of the bottom end of the second mounting frame through a bearing, and a blade is fixedly mounted on the surface of the rotating rod. And a pressing assembly is fixedly mounted at the top end of the first mounting frame. By arranging the pressing assembly and controlling the lead screw, the pressing plate is tightly attached to the bone placed on the placing table, so that the pressing plate can press the bone, the stability during bone cutting is improved, the bone cutting quality is improved, and use is convenient.

The invention discloses a multifunctional injectable hydrogel for tumor photothermal therapy and bone tissue repair and a preparation method thereof, belonging to the field of biomedical materials. The steps are as follows: firstly, micro-nano carbon spheres are synthesized by a hydrothermal carbonization method. Next, add the micro-nano carbon spheres into the chitosan solution and stir evenly to obtain solution A. Again, dissolve sodium β-glycerophosphate and sodium hyaluronate into deionized water at the same time, and stir thoroughly to obtain solution B. Finally, in an ice-bath environment, solution B was added to solution A, stirred evenly, and sterilized by ultraviolet light for 24 hours to obtain an injectable composite hydrogel. The invention has good biocompatibility; it is liquid at room temperature, can be directly injected into bone tumor lesions, and can quickly form a gel in situ at a body temperature of 37°C, realizing effective fixation of photothermal agents and bone defects The rapid filling of bone tumor cells can be achieved through local photothermal therapy, and at the same time, it can effectively promote the repair of bone tissue and realize the comprehensive treatment of bone tumors.

The invention relates to the technical field of bone tumors, and discloses a bone tumor pathological specimen sampling adjustable fixator. The device comprises a slide rail, and the right side of the slide rail is fixedly connected with a barrier strip; a long groove is integrally formed in the front surface of the sliding rail. The inner side wall of the long groove is slidably connected with a handle. The rear end of the handle is fixedly connected with a moving block; the moving block is located on the inner side wall of the sliding rail, and the moving block is in sliding connection with the sliding rail; the concave rail and a sliding rail are fixed to a vertical plate of a medical workbench, so that medical staff can hold a handle to slide, a movable block can move downwards, and the rotating wheels are located in the concave rail; when the movable block moves downwards, a transverse plate rotates, the transverse plate rotates with two rear rotating wheels as the circle center, a second round rod moves in a connecting plate; thereby, the rotating wheel at the rear part is also embedded in the concave track. According to the device, the transverse plate can be rotated to be in a vertical state, and the phenomenon that the occupied space of the device is large is reduced.

The invention belongs to the field of tissue engineering scaffold materials and particularly relates to a near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof. The ZIF8 functionalized gelatin nanofiber scaffold system comprises a gelatin nanofiber scaffold and ZIF8 nanoparticles which are adsorbed onto the gelatin nanofiber scaffold and are subjected to calcination treatment. The invention finds that the ZIF8 nanoparticles have near-infrared-light-sensitive characteristics after being calcined, and can kill tumor cells under the action of near-infrared light stress. The ZIF8 functionalized gelatin nanofiber scaffold system disclosed by the invention is implanted into a defect part after bone tumor excision, and under the action of NIR, a temperature of a GF / ZIF8-phenamil scaffold is increased, so that residual tumor cells are killed. In practical application, in-situ transplantation can be adopted, the requirements of residual tumor cells and bone defect generation after tumor tissue excision can be met, and a new choice is provided for clinical bone tumor treatment.

The invention provides a preparation method of a photothermal anti-bone tumor coating on the surface of a magnesium alloy, which comprises selenium doping of hydroxyapatite micro-particles, synthesis of β-TCP nanofibers, and black phosphorus nanosheets in β-TCP nanofibers. Loading of selenium-doped hydroxyapatite particles and black phosphorus nanosheets@β-TCP nanofibers on the surface of Ca2+ selective adsorption, selenium-doped hydroxyapatite and black phosphorus nanosheets@β-TCP nanofibers gradient electrophoretic co-deposition , so as to form a black phosphorus nanosheet @β‑TCP nanofiber coating with a gradient change in volume fraction embedded in selenium-doped hydroxyapatite. Because black phosphorus nanosheets have excellent photothermal properties and selenium-doped hydroxyapatite has an inhibitory effect on bone tumor cells, it has a good bone tumor treatment function. In addition, due to the degradation of β-TCP nanofibers, the selenium-doped hydroxyapatite coating with a gradient change in the volume fraction of pores has excellent osteogenic properties.