The invention relates to a non-coplanar radiotherapy system in the field of medical equipment, which comprises a radiation source, a frame, an image positioning system and a therapeutic bed. The frame is composed of a revolution base, an L-shaped rotation arm and a C-shaped rotation arm. The revolution base and the L-shaped rotation arm are connected via a revolute pair. The L-shaped rotation arm and the C-shaped rotation arm are connected via a second revolute pair. The radiation source is arranged at one end of the C-shaped rotation arm. The other end of the C-shaped rotation arm is provided with a dosimetric verification device. The image positioning system is composed of two sets of X-ray image systems. The two sets of X-ray image systems are arranged on the two sides of the C-shaped rotation arm in the crossed manner. The therapeutic bed is installed corresponding to the frame, and is composed of a therapeutic bed plate, a slipway and a therapeutic bed support mechanism. The therapeutic bed plate and the slipway are connected via a third revolute pair. The non-coplanar radiotherapy system can be used for the coplanar radiotherapy and the non-coplanar radiotherapy of head and neck neoplasms, bone neoplasms, spinal neoplasms and the like. Meanwhile, the frame is large in motion range and high in flexibility.