Preparation method of photothermal anti-bone tumor coating on magnesium alloy surface

A magnesium alloy and bone tumor technology, which is applied in the field of preparation of selenium-doped hydroxyapatite@nanofiber photothermal anti-bone tumor coating on the surface of magnesium alloy, can solve the problem of restricting the treatment effect of bone tumor and difficult to achieve bone tumor surgery. Integrating dual functions in tumor treatment and other issues, to achieve good bone tumor treatment function, excellent photothermal performance, and strong killing effect

Active Publication Date: 2021-10-22
江汉大学附属湖北省第三人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] So far, the bone implant materials and bone tumor treatment materials that have been developed are limited to the function of surgical replacement repair and bone tumor treatment, respectively. It is difficult to realize the dual-functional integration of bone tumor surgical repair and bone tumor treatment, which restricts the treatment of bone tumors. Effect

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  • Preparation method of photothermal anti-bone tumor coating on magnesium alloy surface
  • Preparation method of photothermal anti-bone tumor coating on magnesium alloy surface

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Embodiment 1

[0026] refer to figure 1 , Preferred Embodiment 1 of the present invention provides a method for preparing a photothermal anti-bone tumor coating on the surface of a magnesium alloy, which is carried out in the following order:

[0027] ① Preparation of selenium-doped treatment solution: Add potassium phenyl selenate, sodium hydroxide, and tributylmethylammonium chloride to deionized water to form potassium phenyl selenate with a concentration of 12mmol / L and sodium hydroxide with a concentration of 90mmol / L And tributylmethyl ammonium chloride concentration is the selenium doping treatment solution of 15mmol / L.

[0028] ② Preparation of prepared solution: Add urea to deionized water to form a prepared solution with a urea concentration of 18 mmol / L.

[0029] ③ Selenium doping of hydroxyapatite microparticles: add 150g of hydroxyapatite microparticles to 1L of the above-mentioned selenium-doped treatment solution, stir with a magnetic stirrer for 30 minutes, then add 90mL of ...

Embodiment 2

[0054] The preferred embodiment 2 of the present invention provides a method for preparing a photothermal anti-bone tumor coating on the surface of a magnesium alloy, which is carried out in the following order:

[0055] ① Preparation of selenium-doped treatment solution: Add potassium phenyl selenate, sodium hydroxide, and tributylmethylammonium chloride to deionized water to form potassium phenyl selenate with a concentration of 15mmol / L and sodium hydroxide with a concentration of 90mmol / L and tributylmethylammonium chloride concentration of 20mmol / L selenium-doped treatment solution.

[0056] ② Preparation of prepared solution: Add urea to deionized water to form a prepared solution with a urea concentration of 3 mmol / L.

[0057] ③ Selenium doping of hydroxyapatite microparticles: add 230g of hydroxyapatite microparticles to 1L of the above-mentioned selenium-doped treatment solution, stir with a magnetic stirrer for 30 minutes, then add 95mL of the above preparation solut...

Embodiment 3

[0063] Preferred embodiment 3 of the present invention provides a method for preparing a photothermal anti-bone tumor coating on the surface of a magnesium alloy, which is carried out in the following order:

[0064] ① Preparation of selenium-doped treatment solution: Add potassium phenyl selenate, sodium hydroxide, and tributylmethylammonium chloride to deionized water to form potassium phenyl selenate with a concentration of 92mmol / L and sodium hydroxide with a concentration of 310mmol / L And tributylmethyl ammonium chloride concentration is the selenium doping treatment liquid of 36mmol / L.

[0065] ② Preparation of prepared solution: Add urea to deionized water to form a prepared solution with a urea concentration of 33 mmol / L.

[0066] ③ Selenium doping of hydroxyapatite microparticles: add 420g of hydroxyapatite microparticles to 1L of the above-mentioned selenium-doped treatment solution, stir with a magnetic stirrer for 30 minutes, then add 162mL of the above preparation...

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Abstract

The invention provides a preparation method of a photothermal anti-bone tumor coating on the surface of a magnesium alloy, which comprises selenium doping of hydroxyapatite micro-particles, synthesis of β-TCP nanofibers, and black phosphorus nanosheets in β-TCP nanofibers. Loading of selenium-doped hydroxyapatite particles and black phosphorus nanosheets@β-TCP nanofibers on the surface of Ca2+ selective adsorption, selenium-doped hydroxyapatite and black phosphorus nanosheets@β-TCP nanofibers gradient electrophoretic co-deposition , so as to form a black phosphorus nanosheet @β‑TCP nanofiber coating with a gradient change in volume fraction embedded in selenium-doped hydroxyapatite. Because black phosphorus nanosheets have excellent photothermal properties and selenium-doped hydroxyapatite has an inhibitory effect on bone tumor cells, it has a good bone tumor treatment function. In addition, due to the degradation of β-TCP nanofibers, the selenium-doped hydroxyapatite coating with a gradient change in the volume fraction of pores has excellent osteogenic properties.

Description

technical field [0001] The invention relates to the field of bone implant medical materials, in particular to a method for preparing a selenium-doped hydroxyapatite@nanofiber photothermal anti-bone tumor coating on the surface of a magnesium alloy. Background technique [0002] Bone tumors seriously endanger human health. The mainstream treatment for bone tumors is surgical resection combined with radiotherapy / chemotherapy, but surgical resection cannot completely and effectively remove tiny lesions and residual bone tumor cells, and will cause bone defects. Toxic and side effects, there are still risks of recurrence and metastasis. Photothermal therapy is to place materials with excellent photothermal conversion properties on tumor lesions, and convert light energy into heat energy through near-infrared light source irradiation to achieve the therapeutic effect of killing tumor cells. As a non-invasive tumor treatment method, photothermal therapy can achieve targeted killi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/32A61L27/50A61L27/54A61L27/58C25D13/02
CPCA61L27/047A61L27/306A61L27/32A61L27/50A61L27/54A61L27/58A61L2300/112A61L2300/416A61L2300/606A61L2400/18A61L2430/02C25D13/02
Inventor 李勇光
Owner 江汉大学附属湖北省第三人民医院
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