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Development and application of cryptotanshinone sustained release solid dispersion pellet

A technology of solid dispersion and cryptotanshinone, applied in the field of medicine, can solve the problem of no published patent, and achieve the effect of simple and feasible technical operation

Inactive Publication Date: 2015-06-17
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the relevant preparations of cryptotanshinone are still in the research stage, and there are almost no related open patents.

Method used

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  • Development and application of cryptotanshinone sustained release solid dispersion pellet
  • Development and application of cryptotanshinone sustained release solid dispersion pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of cryptotanshinone sustained-release solid dispersion pellets

[0023] Precisely weigh 0.1g of cryptotanshinone, 0.5g of ethyl cellulose and 0.1g of polyvinylpyrrolidone, dissolve them together in 30mL of ethyl acetate and 20mL of absolute ethanol, stir until clear, and wait for application. Take by weighing 5g of 25-30 mesh blank ball cores and add them in the fluidized bed hopper, turn on the blower fan and heating device to preheat for a period of time, and start to apply the medicine. The process conditions are: nozzle diameter: 0.5mm; fluidized bed temperature: 20-40°C; liquid spray rate: 0.5-5ml / min; spray gun spray pressure: 0.01-0.1Mpa; blast frequency: 15-35HZ. After adding the drug, the drug-loaded pellets were kept in a fluidized state and continued to boil for 60 minutes to obtain the final product.

[0024] (2) Determination of in vitro release of cryptotanshinone sustained-release solid dispersion pellets

[0025] Carry out according to ...

Embodiment 2

[0031] (1) Preparation of cryptotanshinone sustained-release solid dispersion pellets

[0032] According to the mass ratio of cryptotanshinone and ethyl cellulose: 1:1, 1:5, and 1:10, take 0.1 g of cryptotanshinone and appropriate amount of ethyl cellulose, and dissolve them in 30 mL of ethyl acetate and 20 mL of absolute ethanol In, stir until clarified, wait for the medicine. The sustained-release solid dispersion pellets of each prescription were prepared according to the method described in Example 1.

[0033] (2) Determination of in vitro release of cryptotanshinone sustained-release solid dispersion pellets: the determination method is the same as that described in Example 1.

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Abstract

The invention relates to development and application of a cryptotanshinone sustained release solid dispersion pellet and belongs to the field of medicines. Cryptotanshinone is a salviae miltiorrhizae fat soluble active ingredient, and researches show that cryptotanshinone has obvious anti-inflammatory and antioxidant activities and has an obvious subsidiary function in salviae miltiorrhizae angina treatment, so that the cryptotanshinone sustained release solid dispersion pellet is designed and prepared according to chronopharmacology principles and is applied to treatment on angina. Firstly an appropriate hydrophilic and hydrophobic polymer material is selected as a dispersion carrier, then an appropriate simple and convenient method is utilized for preparing the cryptotanshinone sustained release solid dispersion pellet, and medicine release is regulated by regulating the carrier ratio, so that the medicine release is consistent with attack frequency of the angina.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the development and application of a cryptotanshinone slow-release solid dispersion pellet Background technique [0002] Cryptotanshinone is a fat-soluble diterpene quinone compound extracted from the traditional Chinese medicine Salvia miltiorrhiza, which has a wide range of anti-inflammatory and antioxidant activities, and has a significant auxiliary effect in the treatment of angina pectoris in the traditional Chinese medicine Salvia miltiorrhiza. Studies have shown that the frequency of angina pectoris has a chronological rhythm, reaching a peak at 4 am, and the attack frequency is relatively high from 2 am to 6 am, so it is necessary to maintain a high blood concentration of cryptotanshinone during this time period. However, cryptotanshinone belongs to the BCSII class of drugs, which is almost insoluble in water, has a small dissolution rate in vitro, low bioavailability, and its hal...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/58A61K47/32A61K47/34A61P29/00A61P39/06A61P9/10
Inventor 刘建平李正华
Owner CHINA PHARM UNIV
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