71results about How to "Reduce toxic effects" patented technology

The invention belongs to the technical field of environmental engineering, and discloses a method for preparing a biological carbon immobilized microorganism. The preparation method comprises the following steps: uniformly mixing a polyvinyl alcohol solution with a sodium alginate solution to form a mixed gel solution; mixing a biological carbon adsorbed microorganism bacterial suspension with the mixed gel solution to obtain a mixed bacterial liquid; dropping into a calcium chloride (CaCl2) solution with saturated boric acid for crosslinking, and transferring into an anhydrous sodium sulfate solution for crosslinking to prepare immobilized beads; and washing with normal saline for 3 times for later use. The prepared immobilized beads have the advantages of large specific surface area, high opening ratio, high moisture content and high microorganism activity.

The invention discloses an antibacterial polyurethane fiber and a preparation method thereof. On a dry weight basis, the prepared antibacterial polyurethane fiber contains 0.01%-1.0% of nano-silver in weight percentage. The size and shape of the nano-silver are controllable, and the nano-silver can be uniformly distributed at the interior and on the surface of the fiber. The antibacterial polyurethane fiber has the advantages that an antimicrobial spectrum is wide, the antibiosis is long-lasting, toxic and side effects are few, the preparation method is simple, the spinnability and post-fabricability are good, and the like, thus being widely applied to the fields of medical materials, spinning materials and the like.

The present invention relates to a preparation process of 1,5-pentamethylene diamine. According to the method, a seed liquid containing lysine decarboxylase strains is introduced during lysine fermentation, and mixed fermentation is carried out. The method is suitable for industrial production of 1,5-pentamethylene diamine, minimizes toxicity of pentamethylene diamine to microorganisms to avoid adverse effects on fermentation, makes the subsequent process more simplified, and has certain commercial value.

A method for accumulating drugs or other chemicals within synthetic, lipid-like vesicles by means of a pH gradient imposed on the vesicles just prior to use is described. The method is suited for accumulating molecules with basic or acid moieties which are permeable to the vessels membranes in their uncharged form and for molecules that contain charge moieties that are hydrophobic ions and can therefore cross the vesicle membranes in their charged form. The method is advantageous over prior art methods for encapsulating biologically active materials within vesicles in that it achieves very high degrees of loading with simple procedures that are economical and require little technical expertise, furthermore kits which can be stored for prolonged periods prior to use without impairment of the capacity to achieve drug accumulation are described. A related application of the method consists of using this technology to detoxify animals that have been exposed to poisons with basic, weak acid or hydrophobic charge groups within their molecular structures.

A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3-bromopyruvate (3-BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to target the mitochondrial membrane potential (Δψm) was developed for delivery of 3-BP to cancer cell mitochondria by taking advantage of higher Δψm in cancer cell compared to normal cells. This construct showed remarkable anticancer activity in prostate cancer cells compared to non-targeted construct NT-3-BP-AuNP and free 3-BP. Anticancer activity of T-3-BP-AuNP was further enhanced upon laser irradiation by exciting the surface plasmon resonance band of AuNP and thereby utilizing a combination of 3-BP chemotherapeutic and AuNP photothermal effects. T-3-BP-AuNPs showed markedly enhanced ability to alter cancer cell metabolism by inhibiting glycolysis and demolishing mitochondrial oxidative phosphorylation in prostate cancer cells. Our findings demonstrated that mitochondria targeted and concerted chemo-photothermal treatment of glycolytic cancer cells with a single NP may have promise as a new anticancer therapy.

The invention discloses a preparation method and application of injectable allogeneic adipose acellular matrix particles. The injectable allogeneic adipose acellular matrix particles are obtained in the modes that adipose tissue obtained through liposuction operation is subjected to mechanical chylosis treatment, centrifugal degreasing and a subsequent gentle acellular working procedure, and centrifuged for further degreasing. The adipose tissue comes from human-derived adipose particles discarded by traditional liposuction operation of obese patients. Adipose cell physical crushing and degreasing methods are adopted, a gentle acellular technology is applied, operation is easy and convenient, damage to adipose matrix structure and components is small, an obtained material is closer to thehuman body natural adipose tissue microenvironment, and the three-dimensional structure and active components of the tissue are preserved; and the injectable allogeneic adipose acellular matrix particles can be injected through a 27g of small needle, after injection, proliferation and differentiation of tissue cells in a recipient site are more facilitated, thus tissue repairing and regeneration are promoted, and the long-term filling and rejuvenation effects are achieved. The injectable allogeneic adipose acellular matrix particles are suitable for facial rejuvenation and soft tissue defect repairing.

The invention relates to a composite catalyst for producing polyethylene with a wide molecular weight distribution as well as a production method and an application of the composite catalyst, wherein the composite catalyst comprises two active catalyst components loaded on a carrier, namely one catalyst component is a metallocene catalyst such as mono-cyclopentadienyl, mono-indenyl or mono-fluorenyl, and the other catalyst component is a Ziegler-Natta catalyst with a general formula of M' Xn. Under the action of only one cocatalyst, both the two catalyst components loaded on the modified inorganic carrier can exhibit higher activities, wherein the mono-cyclopentadienyl metallocene component is utilized to produce a part with a high molecular weight; the Ziegler-Natta catalyst part is utilized to produce a part with a low molecular weight; and the obtained polyethylene has characteristics of bimodal / wide molecular weight distribution. The composite catalyst provided by the invention eliminates the influences of interference and poison of different cocatalysts on the different types of catalyst components, at the same time when copolymerizing ethylene with alpha-olefin, the part with the high molecular weight, which is obtained by that the co-monomer component mainly distributes in the mono-cyclopentadienyl component, optimizes constitutions of the co-monomer and improves the performance of the polyethylene product.

The present invention provides methods of reducing the cytotoxic effects of nitric oxide and sulfides comprising coadministering nitric oxide with sulfide. In addition, the present invention provides novel pharmaceutical compositions comprising both nitric oxide and sulfide. The methods and compositions of the present invention may be used in the treatment or prevention of a variety of diseases and disorders, and also in the prevention of cell or tissue damage, including that resulting from ischemi hypoxia.

The invention discloses a novel synthesis method of a polyfluorene derivative and an application in a flow injection fluorescent sensor for a tumor marker. The synthesis method of the polyfluorene derivative comprises the following steps that: 1,4-dibromo p-phenylenediamine (a compound 1) is synthesized; 2,7-dibromo-9,9-bi(3'-(N,N'-dimethylamino) propyl)-fluorene (a compound 2) is synthesized; p-vinyltoluene (a compound 3) is synthesized; the three monomers are polymerized into the polyfluorene derivative by a Heck reaction. A fabrication method of the sensor comprises the following steps that polymethyl methacrylate is adopted to fabricate a flow injection fluorescent flow cell; ferroferric oxide magnetic particles and gold nanoparticles are prepared and assembled into gold covered ferroferric oxide; a primary antibody is modified on gold cladded ferroferric oxide; the polyfluorene derivative is subjected to silicon cladding treatment; a secondary antibody is modified on the surface of the silicon cladded polyfluorene derivative; an immune reaction is conducted; and flow injection fluoroscopic detection is conducted on the tumor marker. The sensor is strong in specificity, high in sensitivity, simple to operate, and low in detecting line.

The invention relates to belongs to the technical field of food processing, and especially relates to a rice sour soup and a preparation method thereof. The rice sour soup is prepared by rice soup, zymocyte, an apple extract, a roxburgh rose extract, sucrose ester, and xanthan gum. The preparation method comprises the following steps: mixing rice soup, the apple extract, and the roxburgh rose extract, performing three-time fermentation on a mixture, and mixing a fermentation object with sucrose ester and xanthan gum. The obtained rice sour soup has abundant nutrition, and can adjust the microecological balance of animal and human body, in addition, the quality stability of the rice sour soup is strong, and the rice sour soup with long-term preservation has no phenomena of layering and bottle expanding.

The present invention relates to the dimethyl sulfoxide solvate of 3-[5-(2-fluorophenyl)-[1,2,4]oxdiazole-3-yl]benzoic acid, wherein the dimethyl sulfoxide solvate has characteristics of good stability, high purity, excellent particle and excellent shape, and is suitable for pharmaceutical preparation applications. The present invention further relates to a preparation method of the dimethyl sulfoxide solvate, a pharmaceutical composition of the dimethyl sulfoxide solvate, and uses of the dimethyl sulfoxide solvate in preparation of drugs for treatment of genetic diseases.

The invention relates to an apremilast novel crystal form. Compared to a known apremilast solid form, the novel crystal form provided by the invention has good stability and beneficial processing and handling characteristics. The crystal form is suitable for solid preparation application. The invention also relates to a preparation method and a pharmaceutical composition of the novel crystal form, as well as an application of the novel crystal form in preparing medicines used for treating psoriatic arthritis.

The invention discloses a method for treating wastewater generated in an acetone production process, which comprises the following steps: (1) wastewater pretreatment: (2) aerobic biological treatment: adding a nitrogen source nutrient substance, a phosphorus source nutrient substance and a trace nutrient substance into the pretreated wastewater, and carrying out aerobic biological treatment; and (3) suspended organic matter removal: sending the wastewater subjected to aerobic biological treatment into a precipitation tank or floatation tank to perform sludge-water separation, wherein no acetone is detected in the effluent water, and the COD (chemical oxygen demand) content is lowered to 100 mg / L below. The method disclosed by the invention has the advantages of high treatment load, stable operation and low treatment cost.

The present invention relates to an artificial feed for arma chinensis. The artificial feed for arma chinensis comprises, in parts by weight, 45-60 parts by weight of egg liquid, 4-6 parts by weight of armyworms or oak silkworms, 4-6 parts by weight of vegetable oil, 4-5 parts by weight of cane sugar, 0.020-0.030 parts by weight of sitosterol and 0.004-0.045 parts by weight of a preservative; andcomprises, in parts by volume, 80-120 parts by volume of milk, wherein the ratio of 1 part by weight of the milk to 1 part by volume of the milk is 1.02-1.04 g / ml. The ingredients of the invention areeasier to obtain, and the feed has more stable quality, lower chemical additive content, and lower price. A small amount of components including the armyworms or the oak silkworms are added to the feed so as to better improve the trace nutrient components in the feed required by arma chinensis. The chemical additive type is reduced so as to reduce the toxicological effect of the chemical additiveon arma chinensis. The present invention also relates to a preparation method of the artificial feed for arma chinensis.

The invention discloses a fusion protein possessing excellent protecting effects against high-dose radiation and a preparation method thereof, belongs to the field of recombinant protein technology, and aims to solve a great number of problems of existing radiation protection preparations that toxicity is strong, side effects are severe, and the like. The form of the amino acid sequence of the fusion protein possessing excellent protecting effects against high-dose radiation is N-Flexiblepeptide-C, wherein N represents N-terminal protein of legionella?pneumophilia flagellin, Flexiblepeptide represents a flexible peptide fragment, and C represents C-terminal protein of legionella?pneumophilia flagellin.

A method for preparing an alkaline Ni-MH secondary battery and its preparation method, wherein the alkaline Ni-MH secondary battery comprises a pole group unit formed by coiling a nickel positive plate, a zinc cathode plate and a barrier diaphragm, a battery case accommodating the pole group unit, and alkaline electrolytic solution, the inner wall surface of the battery case is coated with a layerof lead, stannum or zinc metal coat, or a alloy coating of any two of lead, stannum and zinc; an alkali proof insulating sheath, an insulation circle, a hydrophobic barrier diaphragm or an alkali proof masking tape are arranged between the pole group unit and the inner wall of the battery case for totally isolating the pole group unit from the battery case. The invention further provides a methodfor preparing the alkaline Ni-MH secondary battery. The alkaline Ni-MH secondary battery of the invention greatly decreases the poisoning infection of the nickel impurity to the cathode plate becausethe zinc cathode plate is isolated from the nickel on the inner wall of the battery case, thereby enhancing cyclic life of the Ni-MH secondary battery.

The invention discloses a fungus medicament for preventing postoperative cancer recurrence and a production method thereof. The fungus medicament for preventing postoperative cancer recurrence is prepared by the following raw materials in parts by weight: 23 parts of mythic fungus wall-broken spore powder, 13 parts of mythic fungus extract, 2 parts of agaricus brasiliensis extract, 3 parts of polyporus extract, 1 part of cordyceps sinensis extract, 12 parts of hedyotis diffusa extract and 15 parts of barbat skullcap extract; also the fungus medicament additionally comprises 1 part of ginseng extract and 5 parts of dog meat extract. The production method comprises: uniformly mixing the above extracts with mythic fungus wall-broken spore powder, drying, pulverizing and processing into capsules. The key point of the fungus medicament of the invention is that: according to the theories of traditional Chinese medicine, traditional Chinese medicine syndrome differentiation treatment and 'monarch and minister, assistant and guide', the above six traditional Chinese medicines are subjected to scientific compatibility, so that an effective medicine combination is established. Mice experiments prove that the fungus medicament has substantial cancer inhibiting effect and almost does not have any toxic and side effects on human body. The advantage that the fungus medicament belongs to a nontoxic immunization activator is precisely not owned by many anticancer cancer-treating chemotherapeutic medicaments and other immunization activators.

The invention discloses pesticide-fertilizer granules containing dinotefuran and monosultap as well as a preparation method and application of the pesticide-fertilizer granules to rice, relates to thefield of rice planting, and aims to reduce the negative effect of toxicity of the monosultap by reducing the relative overall dosage of the monosultap; meanwhile, by simultaneously utilizing the combined action of the dinotefuran and the monosultap and attracting pests with flavor attractants, a good insecticide effect can be provided. In addition, the granules are externally provided with non-toxic coatings; the coatings contain deodorant components, so toxicity volatilization is reduced, and personnel poisoning caused in the application process is prevented; the pesticide-fertilizer granuleprovided by the invention contains fertilizer, straw powder and other components with a promotion effect on rice growth, has dual purposes of pesticide and fertilizer, has better action effect and simpler application mode, is longer in action time due to the arrangement of the slow release agent, and is provided with the coating comprising the coating agent and the deodorant on the surface, so that the medicine effect of the granules can be sufficiently prevented from losing.

The invention discloses a compound fertilizer special for pakchoi and application thereof. The compound fertilizer includes an organic fertilizer, an inorganic fertilizer and improved biochar in a weight ratio of 65-75:8-12:15-23, and the pH value of the compound fertilizer is 6-9, wherein the improved biochar is mainly prepared by: standing 2 parts of peanut shell charcoal and 1 part of corn straw charcoal in an LB medium of bacillus subtilis for 24-48h. The application amount of the compound fertilizer is 50-100kg / mu. The invention adopts a special compound fertilizer of appropriate dosage proportion directed at cadmium polluted pakchoi cultivated land having plasmodiophora brassicae. The compound fertilizer is not added with improved biochar, but also is introduced with bacillus subtilis having bacteriostatic effect, and is added with the organic fertilizer and inorganic fertilizer obtained by thorough decomposition of livestock and poultry excrement. Therefore, the special fertilizer not only can effectively reduce the accumulation of heavy metal cadmium in pakchoi, improve the in-situ remediation efficiency of heavy metal contaminated soil, promote the growth of pakchoi, but also can inhibit the growth ofplasmodiophora brassicae woron, and achieves the technical effect of inhibiting the plasmodiophora brassicae of pakchoi.

The invention discloses a component-compatible traditional Chinese medicine for preventing and treating an Alzheimer disease. Raw material for extracts of traditional Chinese medicine effective components contains the following ingredients: ginseng or total saponins of panax ginseng; coptis chinensis or total alkaloids from coptis chinensis; and ligusticum wallichii or ligusticum wallichii alcoholextract. Compared with the original traditional Chinese medicine formula (Prepared polygonum multiflorum, ginseng, acorus gramineus, coptis chinensis and ligusticum wallichii), indexes of new compatibility of traditional Chinese medicine components in an animal behavior aspect and pathology change are better than those of compatibility of the original formula, and the new compatibility of the traditional Chinese medicine components has the same effects with the original formula in the aspect of controlling inflammation level; meanwhile, toxic effect and dosage of the original formula are reduced, the effective ingredients including ginsenoside, berberine and ligustrazine of the component-compatible traditional Chinese medicine are also clear and can achieve pharmacological effects by virtue of a blood brain barrier, the traditional Chinese medicine component compatibility accords with traditional Chinese medicine theory, the material basis for efficacy is clear, and characteristics ofthe modern traditional Chinese medicinal preparation are reflected, and therefore, the component-compatible traditional Chinese medicine disclosed by the invention is an ideal medicine for preventingand treating the Alzheimer disease.

The invention belongs to the technical field of food processing and especially relates to a processing method of red sour soup. The processing method comprises the following steps: material selection,soaking, primary pulverizing, primary fermenting, secondary pulverizing, secondary fermenting, conditioning and fragrance increasing. The prepared red sour soup contains rich nutrients and has the functions of promoting the production of the body fluid, quenching thirst, promoting appetite and strengthening the spleen. The red sour soup is cool, refreshing and unique in flavor, and lactic acid inthe sour soup can regulate the microecological balance in the intestinal tracts of animals and human bodies, is beneficial to body health, has the effects of inhibiting growth of putrefaction bacteria in the intestinal tracts and weakening toxin production of the putrefaction bacteria in the intestinal tracts, also has the health-care and medical treatment effects of helping digestion, preventingconstipation, preventing aging of cells, reducing cholesterol, resisting tumors, regulating the physiological functions of human bodies and the like, and has nonnegligible nutritional health-care effects. The red sour soup has high stability of quality and is not liable to generate precipitation, turbidity and other phenomena in long-term storage, and the capsaicin content is stable.

The invention discloses a method for producing ethanol by recycling anaerobic digestion effluent and vinasse clear liquid and belongs to the technical fields of waste water treatment and ethanol fermentation industry. The method comprises the following steps: mixing and blending membrane filtrate obtained after membrane filtration of anaerobic digestion effluent, part of vinasse clear liquid, other material mixing water and crushed cereal raw materials, and performing processes of liquefying, saccharifying, fermenting and distilling to obtain ethanol, wherein the membrane filtrate accounts for30 to 90 percent of the total weight of the blending water, the vinasse clear liquid accounts for 10 to 40 percent of the total weight of the blending water, and the rest is other material mixing water; and the concentration of volatile acid of the blending water is controlled to be 100 to 1200 mg / L (based on acetic acid) by adjusting the proportion of the membrane filtrate, the vinasse clear liquid and other material mixing water or adding the acetic acid. By the method, discharge of ethanol production waste water is greatly reduced and water resources are saved; meanwhile, the problem thatthe ethanol is fermented to generate acid is effectively avoided, the alcohol yield is significantly increased, the utilization rate of the raw materials is increased by 1 to 5 percent, and the production energy consumption and cost of the ethanol are reduced.

The invention relates to a traditional Chinese medicine formula used for treating burns. The traditional Chinese medicine formula used for treating burns is composed of, by mass, 45 to 50g of Eucommiaulmoides, 40 to 45g of Chinese gall, 20 to 25g of cortex moutan, 5 to 10g of winter plum blossom, and 0.1 to 0.5g of borneol. The traditional Chinese medicine formula is capable of achieving synergistic effects of the traditional Chinese medicine ingredients, reducing toxic effects, treating burns, relieving pain and itching, and avoiding scars.

The invention discloses a device used for stir-frying traditional Chinese medicines with wine and capable of clearing dust and performing stirring through blades. The device comprises a plug and a base. A power line is arranged between the plug and the base. An electric motor is arranged on the left side of the top of the base, a stirring cylinder is arranged at the top of the base, and a housing is arranged in the stirring cylinder. A stirring shaft is arranged in the housing, a plurality of blowers and bearings are arranged on the inner wall of the left side of the housing, a compressor is arranged on the right side of the top of the housing, a feeding device is arranged on the right side of the top of the housing, a control panel and a discharging device are arranged on the right side of the housing, and a heat preservation layer is arranged on the inner wall of the housing. A transmission belt is arranged between the stirring shaft and a connecting shaft, the periphery of the outer wall of the stirring shaft is connected with a stirring rod and a blade stirring device at the inside of the housing. Blowing pipes are arranged on the right sides of the blowers. A wine jar is arranged on the left side of the compressor. A pipeline is arranged on the left side of the wine jar and penetrates through the housing and the heat preservation layer to be connected with a spraying nozzle. The device is simple in structure and convenient to use.

The invention provides microbial fertilizer for soil improvement and remediation, which is prepared from the following raw materials in parts by weight: 65 to 75 parts of charcoal, 10 to 14 parts of potassium chloride, 4 to 6 parts of polypropylene peptide amine, 6 to 10 parts of compound microbial agent, 0.5 to 1.5 parts of lignin iron, and 3 to 5 parts of attapulgite. According to the microbialfertilizer for soil improvement and remediation, which is provided by the invention, the charcoal is used as the main raw material and is matched with a certain amounts of potassium chloride, polypropylene peptide amine and compound microbial agent, so that rich organic matter and elements of nitrogen, phosphorus and potassium can be provided for soil, soil hardening and aggregating phenomena areeffectively improved, and air permeability and the water-retaining property of the soil are enhanced; by the lignin iron and the attapulgite, an iron shortage phenomenon of the soil is improved and deleteriousness of the soil is reduced, so that comprehensive performance of the soil is greatly improved, fertility of the soil is improved, and yield of crops is reinforced.

The invention concerns a pharmaceutical comprising an adequate pharmaceutical support and an element selected among the group consisting of a nucleotide sequence coding for a peptide of the ONECUT family a vector comprising said nucleotide sequence, the polypeptide sequence coded by said nucleotide sequence and / or a cell line transformed by said vector and expressing the peptide of the ONE CUT family.

The invention relates to an agricultural product production technology in the field of agricultural fertilizers, in particular to foliar spray fertilizer for millets and a preparation method and application of the foliar spray fertilizer. The foliage spray fertilizer is prepared from the following components in parts by weight: 0.8-1.5 parts of selenium, 10-40 parts of sulfur, 5-15 parts of manganese, 5-15 parts of zinc, 10-40 parts of magnesium, 1-4 parts of alkyl polyglycoside, 10-30 parts of chitosan, 2-6 parts of chitosan quaternary ammonium salt, 15-35 parts of calcium and 1-5 parts of molybdenum.In order to solve the problem that selenium absorption and utilization of plants are influenced, the relation between sulfur and selenium is taken as an entry point, the proper proportion range of sulfur and selenium, cation type selection and dosage matched with sulfur, surfactant dosage adjustment after sulfur and other elements are added, leaf surface protection measures and the like are emphatically studied, and a series of experiments are carried out. The invention provides the preparation method and application of the selenium-enriched high-yield spray fertilizer for millet.