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Component-compatible traditional Chinese medicine for preventing and treating Alzheimer disease

A technology of Alzheimer's disease and traditional Chinese medicine, applied in the field of traditional Chinese medicine research, can solve the problems of many components, adverse reactions and contraindications, and achieve the effect of reducing toxic effects, reducing drug dosage, and clear composition compatibility

Inactive Publication Date: 2018-09-11
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above prescriptions have significant functions, they have many components, and the potential adverse reactions and contraindications are less predictable

Method used

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  • Component-compatible traditional Chinese medicine for preventing and treating Alzheimer disease
  • Component-compatible traditional Chinese medicine for preventing and treating Alzheimer disease
  • Component-compatible traditional Chinese medicine for preventing and treating Alzheimer disease

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Experimental program
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Effect test

Embodiment Construction

[0027] 1.0 Preparation of pharmaceutical ingredients

[0028] Total ginseng saponins: the extraction method is as follows, take ginseng medicinal materials, cleanly select, cut into sections, add water and decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is filtered, the combined filtrate is absorbed by D101 macropores Resin column, eluted with water until colorless, then eluted with 60% ethanol, collected the 60% ethanol eluate, concentrated the filtrate to a clear paste with a relative density of 1.06-1.08 (80°C), dried at 100°C, and pulverized with 100 mesh , to get the finished product, total ginsenosides>80% put into storage, the yield is 4%.

[0029] Coptis chinensis total alkaloids: the extraction method is as follows, take Coptis chinensis medicinal materials, cleanly select, crush to 12mm, add dilute sulfuric acid to keep warm and soak for extraction, add lime water and sodium chloride to alkalinize the crystals, filter, add water t...

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Abstract

The invention discloses a component-compatible traditional Chinese medicine for preventing and treating an Alzheimer disease. Raw material for extracts of traditional Chinese medicine effective components contains the following ingredients: ginseng or total saponins of panax ginseng; coptis chinensis or total alkaloids from coptis chinensis; and ligusticum wallichii or ligusticum wallichii alcoholextract. Compared with the original traditional Chinese medicine formula (Prepared polygonum multiflorum, ginseng, acorus gramineus, coptis chinensis and ligusticum wallichii), indexes of new compatibility of traditional Chinese medicine components in an animal behavior aspect and pathology change are better than those of compatibility of the original formula, and the new compatibility of the traditional Chinese medicine components has the same effects with the original formula in the aspect of controlling inflammation level; meanwhile, toxic effect and dosage of the original formula are reduced, the effective ingredients including ginsenoside, berberine and ligustrazine of the component-compatible traditional Chinese medicine are also clear and can achieve pharmacological effects by virtue of a blood brain barrier, the traditional Chinese medicine component compatibility accords with traditional Chinese medicine theory, the material basis for efficacy is clear, and characteristics ofthe modern traditional Chinese medicinal preparation are reflected, and therefore, the component-compatible traditional Chinese medicine disclosed by the invention is an ideal medicine for preventingand treating the Alzheimer disease.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine research, in particular to a traditional Chinese medicine for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), also known as senile dementia, is the fourth leading killer of the elderly after heart disease, cancer, and stroke. Its most notable behavioral characteristics are learning and memory functions progressive decline. As China gradually enters an aging society, the number of AD patients is increasing. The prevalence of AD among the elderly over 65 years old in China is 3.21%, more than 7 million AD patients, ranking first in the world. AD has a long course of disease, many complications, and requires long-term care, which not only affects the quality of life of patients, but also brings serious social and economic problems to families and individuals. Therefore, the research on the pathogenesis an...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P25/28
CPCA61K36/236A61K36/258A61K36/718A61P25/28A61K2300/00
Inventor 李浩刘剑刚马丽娜刘美霞韦云杨洋王志勇
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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