The invention discloses a pharmaceutical preparation for treating diabetic cardiomyopathy and a preparation method thereof. The pharmaceutical preparation is prepared from the following raw materialsin parts by weight: 10-20 parts of wolfberry, 10-20 parts of fructus schisandrae chinensis, 10-20 parts of semen ziziphi spinosae, 10-15 parts of caulis polygoni multiflori, 10-20 parts of Chinese dates, 10-20 parts of aralia taibaiensis, 8-13 parts of herba taxilli, 3-5 parts of ginseng, 8-13 parts of radix trichosanthis, 8-13 parts of radix ophiopogonis, 5-10 parts of rhizoma chuanxiong and 3-5parts of rhizoma coptidis. The preparation method of the pharmaceutical preparation comprises the following steps: decoction, mixing, concentration and spray drying. Compared with the prior art, the pharmaceutical preparation has the efficacies of reducing blood pressure and blood sugar, protecting cardiac muscles, easing pain, diminishing inflammation, regenerating body fluid, clearing heat, tonifying vital energy, nourishing yin, tonifying the spleen, the liver and the kidney and nourishing the heart; and the preparation method is simple, wide in raw material source and suitable for industrial large-scale production.