The invention discloses a lansoprazole special superfine powder freeze-dried preparation and a preparing method thereof. The method comprises the following steps: step 1, mixing a lansoprazole crude product and anhydrous ethanol, heating and stirring to dissolve, decolorizing with activated carbon, carrying out heat filtration to remove activated carbon, dropwise adding water for injection, carrying out cooling crystallization, filtering, leaching the filter cake with anhydrous ethanol, carrying out suction filtration, carrying out vacuum drying, and thus obtaining a lansoprazole refined product; step 2, smashing the dried lansoprazole refined product with gas flow into a superfine powder; and step 3, dissolving the lansoprazole superfine powder in water for injection, dropwise adding a sodium hydroxide solution to regulate a pH value, adding an auxiliary material, stirring evenly, fixing volume, filling, freeze-drying, and thus obtaining the lansoprazole special superfine powder freeze-dried preparation. The lansoprazole special superfine powder freeze-dried preparation has the advantages of high purity, less impurity, high stability, small particles, good solubility, small toxic and side effects, difficult irritability and the like.