The invention discloses moisture absorption prevention thermal-insulating interlayer glass and a preparation method thereof. The interlayer glass comprises two layers of glass and a thermal-insulating adhesive film, wherein the thermal-insulating adhesive film is arranged between the two layers of glass; the thermal-insulating adhesive film comprises a modified thermal-insulating adhesive, an antioxidant and barium sulfate; and the modified thermal-insulating adhesive is prepared from the following components: polyethylene, polyurethane resin, emulsified silicone oil, organic silicon epoxy resin, polyvinyl butyral, nanosilicon dioxide, thermal-insulating particles, cellulose ether, superfine zinc powder, isopropanol, a light stabilizer and butanediol dimethylacrylate. The preparation method comprises the following steps: mixing the modified thermal-insulating adhesive, the antioxidant and barium sulfate, and performing extrusion pelletizing so as to form an adhesive film; and clinging a first layer of glass, the adhesive film and a second layer of glass, performing heating and film melting under a vacuum condition, and discharging air to completely cling the two layers of glass together, thereby obtaining the moisture absorption prevention thermal-insulating interlayer glass. The interlayer glass disclosed by the invention has high properties of moisture prevention and thermal insulation, and function integration is achieved.