The invention discloses preparation and a prescription technology for berberine hydrochloride tablet preparation. The berberine hydrochloride tablet preparation is prepared from the following raw materials in parts by weight: 1 to 15 parts of berberine hydrochloride, 0.36 to 36 parts of corn starch, 0.06 to 6 parts of carboxymethyl starch sodium, 0.25 to 25 parts of 70% ethyl alcohol, 0.20 to 20 parts of 8% starch slurry, 0.004 to 0.40 part of magnesium stearate and 0.004 to 0.40 part of silicon dioxide. By means of the preparation of the berberine hydrochloride tablet preparation, a berberinehydrochloride tablet can be prepared. According to the prepared berberine hydrochloride tablet, carboxymethyl starch sodium is utilized for improving internal disintegration of particles, so that content dissolution is quickened, and the efficiency is improved; the amount of utilizing a 70% ethanol solution as a wetting agent is reduced; the starch slurry is added to serve as an adhesive, so thatparticle formation and particle fluidity are facilitated; silicon dioxide is added, so that the sticking phenomenon in a particle tabletting process is improved, fluidity is improved, the phenomenonthat the berberine hydrochloride tablet particles are prone to sticking in a tabletting process is solved, tablet weight difference is reduced, a finished product yield is improved, and content dissolution is quick.