Thesium chinense tablet and preparation method and application thereof

Abstract

The present invention relates to the field of thesium chinense preparations and particularly relates to a thesium chinense tablet and a preparation method and an application thereof. The thesium chinense comprises the following raw materials in parts by weight: 80-120 parts of a thesium chinense extract, 10-20 parts of lactose, 1-5 parts of hydroxypropyl cellulose, 2-8 parts of magnesium stearateand 10-30 parts of polyoxyethylene WSR 303. The prepared tablet is good in slow release effect, high in dissolution rate, good in stability, good in fluidity, smooth in surface and small in tablet weight difference.

Description

technical field [0001] The invention relates to the field of barley preparations, in particular to a barley tablet, a preparation method and application thereof. Background technique [0002] Thyme grass, the Chinese aliases are all milk grass, ground pomegranate, fine beard grass, a pine, accumulated herbs, pearl grass, Artemisia phoenix buds, Qinglong grass, coral grass, grass-eating grass, stone rapeseed, pine hair ginseng, small Grass and white wind grass, etc., are the general designation of various plant medicinal materials of the genus Thyme (Thesium L.) in the family Santalaceae (Santalaceae). They are distributed in tropical and temperate regions. There are 8 species in my country, which are produced in all provinces; The dried whole herb of Thesium chinense Turcz. or its variant T. chinense Turcz. varlongipedunculatum Chu. Studies have found that thymegrass mainly contains polysaccharides, glycosides, flavonoids, alkaloids, steroids, organic acids and mineral elemen...

AI Technical Summary

Problems solved by technology

[0003] Through the research on the existing Bairui Tablets, it was found that because of the poor water solubility of the active ingredient flavonoids in Thymeca officinalis, the poor oral absorption effect, and the low dissolution rate in vitro, resulting in low bioavailability in vivo, oral administration of Thymeca officinalis Tablets have a short half-life in the human body. Therefore, in order to maintain a stable blood concentration, a large dose or multiple doses must be administered. However, large doses or multiple doses will affect the adaptability of patients, especially children. , also aggravated the toxic and side effects. In addition, the existing Bairui tablets also have the problems of poor stability and large differences in tablet weight.

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