The invention provides an environment-friendly anti-radiation coating .The environment-friendly anti-radiation coating is prepared from, by weight, 20-30 parts of novolac epoxy, 10-20 parts of expanded graphite, 5-10 parts of carbon nano tubes, 1-5 parts of titanium dioxide, 5-10 parts of glass powder, 5-10 parts of talcum powder, 10-15 parts of kaolin powder, 10-15 parts of wollastonite powder, 0.5-3 parts of hydroxypropyl methyl cellulose, 1-5 parts of acrylic acid bicyclo-pentenyl oxy-ethyl ester and 20-30 parts of water .The invention further provides a preparation method of the environment-friendly anti-radiation coating .All the components in the environment-friendly anti-radiation coating are matched and make respective advantages complementary to one another, and on the premise that good adhesive force is kept, the coating has the advantages of excellent corrosion prevention, radiation protection, bacterium resistance, flame retardance, high temperature resistance, fracturing resistance, corrosion resistance, cold and hot alternation resistance, storage stability and the like .