41results about How to "Inhibition of contractility" patented technology

Systems and methods of tissue remodeling or altering a surface of a skin of a patient are provided. A method includes increasing myostatin activity in a target tissue. Methods can include increasing myostatin activity in a target tissue in addition to various tissue remodeling techniques, including cryogenic cooling of target tissue for tissue remodeling.

A Chinese medicine for treating hypertension, hyperlipemia and hyperglycemia is prepared from 22 Chinese-medicinal materials including chrysanthemum flower, astragalus root, red sage root, haw, etc.

The purpose of the present invention is to provide a urethane foam sheet with a substrate. The urethane foam sheet is thin, has excellent flexibility and a fine uniform structure, is easy to handle, has high strength, and does not contract. This urethane foam sheet is characterized by comprising a foam obtained by applying a mixture of a urethane resin, an organic solvent, water and a fluorine-based surfactant to one side of a substrate, which is a film of any one of a polyethylene terephthalate film, a polypropylene film or a methylpentene polymer film, and then applying heat. The urethane foam sheet is further characterized in that the organic solvent is a mixed solution of toluene and methyl ethyl ketone, and the foam is constituted by microcells having a continuous ventilation structure.

A Chinese medicine for preventing and treating coronary heart disease, angina pectoris and cerebrovascular accident is prepared from American ginseng, notoginseng, borneol and dalbergia wood.

The invention discloses tile glue for a ceramic thin plate. The tile glue for the ceramic thin plate comprises the following components in percentage by weight: 20 to 32 percent of silicate cement, 40 to 48 percent of quartz sand, 0.8 to 6.4 percent of concrete expanding agent, 0.8 to 4 percent of dispersible latex powder, 0.08 to 0.48 percent of cellulose ether, 0.08 to 0.8 percent of early strength agent, 0.08 to 0.48 percent of thixotropic lubricant, 0.08 to 0.8 percent of wood fiber, 0.08 to 0.48 percent of water repellent, 0.08 to 0.48 percent of anti-whiskering agent and 16 to 24 percent of emulsion. The tile glue for the ceramic thin plate is energy-saving and environmentally-friendly, has excellent performance, can inhibit contraction, prevents cracking, avoids hollowing and has the advantages of slippage resistance, whiskering resistance, low water absorption, high wear resistance and the like.

The invention provides a composition, and a preparation method and applications thereof. The composition comprises, by weight, 15 to 30 parts of rosemary essential oil, 1 to 5 parts of Artemisia apiacea extract, and 200 to 300 parts of tea bran extract. The formula is reasonable; synergistic interaction of the components is achieved; in preparation of a scalp nourishing agent, the composition is combined with a plurality of scalp conditioning agents, so that the nourishing effect on scalp is improved; the composition is capable of washing hair, is safe and non-irritant, is capable of preventing alopecia, promoting hair growth, blacking and brightening hair, improving dry and regged hair, is promising in application prospect, and is high in market value.

The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure and related disorders thereto

The invention discloses a preparation method of fleshfingered citron fruit wine and a product prepared by the same. The objective is to solve the problem that in the proportioning process of conventional fleshfingered citron fruit-citrus wine, two types of fruit juices in mixture have to be appropriate, otherwise the fermentation effect is poor and taste is not good, affecting the quality of wineafter fermentation. The method comprises the following steps: choice of materials, addition of yeast, pre-fermentation, post-fermentation and aging. Since the invention adopts fleshfingered citron fruits as a raw material to carry out fermentation to prepare the fruit wine, the problem of easy souring existing in conventional products is effectively avoided, the prepared fleshfingered citron fruitwine is purely sweet, and the quality of the wine is good. The fleshfingered citron fruit wine disclosed by the invention has the effects of inhibiting the intestinal smooth muscles, dilating the coronary vessels and increasing the blood flow of the coronary arteries, can also inhibit myocardial contractility, decrease the heart rate, decrease blood pressure and protect experimental myocardial ischemia, and also has the effects of relieving asthma and eliminating phlegm. The invention innovatively uses fleshfingered citron fruits to be fermented alone under the natural condition to prepare the wine, so that the nutritional value in the fleshfingered citron fruits is sufficiently exerted, so that the invention is a major innovation for fleshfingered citron fruit wine.

The invention relates to castor oil modified emulsion for improving edge corrosion resistance of a waterborne coating. The castor oil modified emulsion for improving the edge corrosion resistance of the waterborne coating is obtained by core-shell emulsion polymerization of core monomer pre-emulsion and shell monomer pre-emulsion, a castor oil modified monomer is added in the shell monomer pre-emulsion, and the formula of the castor oil modified monomer comprises 38.96% to 65% of castor oil, 5.96% to 22.16% of isocyanate acrylate, 23.70% to 48.90% of acetone, 0.19% to 0.65% of an organic tin catalyst, and 0.0019% to 0.0065 % of a polymerization inhibitor, and the components are condensed and vacuum removal of acetone is carried out to obtain the castor oil modified monomer. The castor oil modified emulsion for improving the edge corrosion resistance of the waterborne coating disclosed by the invention increases the reactivity of the castor oil, microgel is synthesized through a manner of the core-shell emulsion polymerization, and when the microgel is used in the waterborne coating, a triglyceride structure of the castor oil is better exposed on the surfaces of latex particles in a shell part of the emulsion, furthermore, the triglyceride structure obviously inhibits film shrinkage, and improves the edge corrosion resistance of the film in the solidification process of the film.

A method of abdominally stabilizing a patent selected for CardioPulmonary Resuscitation (CPR) and whose chest is in an uncompressed state includes wrapping a substantially inextensible flexible belt around the abdomen substantially without applying pressure to the abdomen, and locking the belt in the wrapped position. Also disclosed is a belt for abdominal stabilization.

The invention discloses a vibrating diaphragm base material, a preparation method thereof, a vibrating diaphragm and a loudspeaker. the vibrating diaphragm base material comprises a first bonding layer, a second bonding layer, a first high polymer material layer made of a high polymer material, a second high polymer material layer made of a high polymer material and a porous damping material layermade of a porous damping material; the porous damping material layer is provided with a first side surface and a second side surface which are arranged back to back, the first high polymer material layer is bonded on the first side surface through the first bonding layer, and the second high polymer material layer is bonded on the second side surface through the second bonding layer. The vibrating diaphragm base material has the beneficial effects that (1) the size of a product prepared from the vibrating diaphragm base material can be kept consistent; and (2) the vibrating diaphragm base material can inhibit and improve the variation of the performance of a high polymer material under a high-temperature condition, so that the amplitude of a loudspeaker and other products adopting the vibrating diaphragm base material is slightly deviated along with the temperature rise, and the stability of the performance of the product is improved.

The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and / or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and / or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF<40% by radionuclide ventriculography; LVEF≤35% by echocardiography or ventricular contrast angiography; and conditions related thereto.

The invention discloses phosphogypsum lightweight concrete that comprises the following raw materials by weight: 200-500 parts of phosphogypsum, 300-650 parts of cement, 30-150 parts of an admixture,1-5 parts of a foaming agent, 2-20 parts of quick lime, 1-5 parts of an inorganic mineral additive, 1-3 parts of an additive and 400-750 parts of water. The concrete can effectively utilize phosphogypsum, enhances durability and mechanical properties, and is light in weight, high in strength and low in manufacturing cost.

The invention discloses a wrinkle-removing, moisturizing and skin-protecting lotion and a preparation method thereof. The wrinkle-removing, moisturizing and skin-protecting lotion comprises the following components in percentages by weight: 0.1 to 1% of stevioside, 20 to 65% of an emulsifying thickener, 0.01 to 0.1% of chelate, 0.01 to 0.2% of sodium hyaluronate, 3 to 25% of a humectant, 0.05 to 5% of polyglutamic acid, 1 to 5% of active polypeptide, 0.1 to 2% of a radix gentianae extract and 0.1 to 1% of a preservative, with the balance being water. The wrinkle-removing, moisturizing and skin-protecting lotion provided by the invention has the characteristics of significant use effect, mild performance, no irritation and no side effect; the wrinkle-removing, moisturizing and skin-protecting lotion provided by the invention has the characteristics of simple production process, low cost, safety, environmental protection and applicability to all people, has extremely high economic value,and can enable the skin to be fine, smooth, transparent and just like new skin.

A micropore composite fired brick tackified and modified with acrylic acid is disclosed. The micropore composite fired brick is prepared from, by weight, 40-43 parts of municipal sludge, 8-9 parts of mesoporous silica, 22-25 parts of shale, 38-40 parts of gangue, 14-15 parts of rice hull, a proper amount of water, 6-7 parts of nepheline tailings, 7-9 parts of bamboo charcoal, 3-4 parts of acrylic acid, 2-3 parts of borax and 5-6 parts of hilly loess. The nepheline tailings and the hilly loess are compounded with the acrylic acid through a series of processes, thus playing a role of a filling material and increasing viscosity of mixed mud materials. Through mixing with other raw materials, the water content of a brick blank is increased obviously and the ratio of briquetting of brick blanks is increased. The fired brick is compact in appearance, comprises micropores inside, and is good in thermal insulation effects, good in toughness, high in strength and not liable to break. The raw materials are simple and easily available. A process is convenient in industrial control and suitable for large-scale production.

The invention provides a black-bone chicken peptide composition which is prepared from the following ingredients in parts by weight: 10 to 30 parts of black-bone chicken egg white peptide and 10 to 300 parts of black-bone chicken oligopeptide. The prepared black-bone chicken peptide composition prepared by the invention has effects of easing pain, resisting inflammation and preventing and treatingprimary dysmenorrhea. The invention further provides application of the black-bone chicken peptide composition in preparing health care food, food and medicine for preventing and treating dysmenorrhea and gynecological inflammation. The black-bone chicken peptide composition can serve an effective ingredient of health care food, food and medicine for improving, preventing and treating primary dysmenorrhea and / or treating gynecological inflammation.

The invention provides a health-preserving composition for toxin expelling and beauty maintenance, which comprises the following components: 5-7 parts by weight of asparagus cochinchinensis, 8-12 parts by weight of lotus seeds, 6-8 parts by weight of angelica, 4-6 parts by weight of quispualis indica, 2-5 parts by weight of agastache rugosus, and 5-7 parts by weight of pinus koraiensis. The composition of the invention effectively combines the above components to play a synergistic role, can effectively expel toxin in internal organs, and also has other disease-treating and health-preserving efficacy.

The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure and related disorders thereto.

The invention discloses glass heat isolation water-based paint and a preparation method thereof. The glass heat isolation water-based paint comprises a raw material body, and further comprises graphene, a first additive and a second additive, wherein the graphene accounts for 0.01 to 5 percent of the raw material body by mass; and the total amount of the first additive and the second additive accounts for 0.1 to 7 percent of the raw material body by mass. According to the glass heat isolation water-based paint and the preparation method thereof, the intensity of the glass heat isolation water-based paint is improved by adding of the graphene; by the use of the high heat conduction function of the graphene, the shortcoming that the heat accumulation temperature on the surface of glass coated with the existing heat absorption type glass heat isolation paint is high is overcome; furthermore, the friction resistance of the water-based paint, the bonding strength with a base material and the impact resistance are obviously improved; and the paint has obvious hydrophobic self-cleaning and heat isolation functions, can meet the environment-friendly development trend and the requirement, and has a wide application prospect in the field of heat preservation and isolation of building window glass and automobile glass.

The invention provides medulla junci qi-regulating foot bathing powder and a preparation method of the medulla junci qi-regulating foot bathing powder. Each 35g of the medulla junci qi-regulating foot bathing powder is composed of 20g of traditional Chinese medicinal mixed powder and 15g of traditional Chinese medicinal mixed medicinal residues, the 20g of traditional Chinese medicinal mixed powder is composed of medulla junci, dried tangerine or orange peel, rhizoma cyperi, fructus akebiae, semen litchi, fructus citri sarcodactylis, pericarpium arecae, exocarpium citri grandis, semen canavaliae and rhizoma corydalis at the ratio of 10: (5-8): (4-7): (4-6): (3-5): (2-4): (2-3): (1-3): (2-3): (1-2), and the 15g of traditional Chinese medicinal mixed medicinal residues are obtained after the raw materials in the 20g of traditional Chinese medicinal mixed powder are processed. The preparation method comprises the following steps: (1) carrying out pretreatment on the raw materials; (2) carrying out ultrasonic extraction; (3) carrying out concentrating and drying; and (4) carrying out grinding and sterilizing. For the medulla junci qi-regulating foot bathing powder and the preparation method of the medulla junci qi-regulating foot bathing powder, the preparation process is concise and scientific, and the prepared foot bathing powder is convenient to use and obvious in curative effects, and has the good qi regulating efficiency.

The invention discloses microporous sintered bricks sintered bricks with interface bonding improved by redispersable rubber powder. The microporous sintered bricks are made from, by weight, 40-43 parts of urban sludge, 8-9 parts of mesoporous silica, 22-25 parts of shales, 38-40 parts of coal gangue, 14-15 parts of rice husk, a proper amount of water, 2.5-3 part of potassium feldspar, 2-3 parts of paraffin, 0.8-1 part of polyvinyl alcohol, 2-3 parts of redispersable rubber powder and 11-13 parts of household garbage. The household garbage is added to green brick pug through a series of process modification, the microporous sintered bricks sintered bricks have stronger hydrophily by cooperating with the polyvinyl alcohol and the redispersable rubber powder, water molecules can be absorbed through compounding to form a layer of solvated water film having a certain mechanical strength, so that other raw materials on the surface of the household garbage can be fully hydrated, microcracks are filled through mutual fusion, strong mechanical anchorage is also formed between household garbage and other substrates, accordingly the interface bonding strength is improved, and further the strength of green bricks is improved.

The invention discloses a traditional Chinese medicine for treating coronary heart disease angina pectoris and preventing and treating cerebrovascular accident diseases and its processing technology, which belongs to the technical field of traditional Chinese medicine. It is composed of the following raw materials according to the weight ratio: (150-450): (400-800): (0.3-3): (10-50). In the present invention, Panax notoginseng promotes blood circulation and removes blood stasis as the king, American ginseng tonifies deficiency, strengthens the body and benefits camp as the subject, reduces fragrance, regulates qi and promotes blood stasis, enhances Sanqi, activates blood circulation and removes blood stasis as assistant, and dipterocarp introduces various medicines into the whole body as the envoy; the medicines are simple but not complicated However, the monarch, the minister, the assistant and the envoy are all-round, attacking and supplementing and applying double entendres; it is suitable for both treatment and health care, and the medicine tastes mild, and it can be used by both sexes with cold and heat; it has high curative effect, low medicine cost, easy to take, and the medicine has no side effects and no contraindications. , safe and reliable, easy to grasp and use, and also has the characteristics of quick onset and short course of treatment, and the effective rate can reach 98%.

The invention relates to an alumina-carbon composite nanofiber aerogel material and a preparation method thereof.The method comprises the steps that alumina nano powder and a sulfuric acid solution are evenly mixed with water, a mixed solution is obtained, then the mixed solution is placed at the temperature of 150-300 DEG C for a hydrothermal reaction for 12-18 h, and gel is obtained; aging the gel to obtain aged gel; carrying out solvent replacement on the aged gel by adopting DMSO (Dimethylsulfoxide) as a solvent; soaking the gel subjected to solvent replacement in a Kevlar nanofiber dispersion liquid for 24 to 96 hours; sequentially carrying out solvent replacement and supercritical drying on the impregnated gel, so as to prepare an aluminum oxide-Kevlar nanofiber aerogel material; and carrying out high-temperature cracking on the aluminum oxide-Kevlar nanofiber aerogel material, so as to prepare the aluminum oxide-carbon composite nanofiber aerogel material. The aluminum oxide-carbon composite nanofiber aerogel material which is good in temperature resistance, tough, low in density, efficient in heat insulation and resistant to radiation is obtained.

The invention discloses fructus citri sarcodactylis-Pu'er tea summer health-care tea and a preparation method and application thereof, which relates to the technical field of health-care tea. The fructus citri sarcodactylis-Pu'er tea summer health-care tea consists of fructus citri sarcodactylis and Pu'er tea, and the weight ratio of the fructus citri sarcodactylis to the Pu'er tea is 1 to (1 to 5). The formula has the effects of soothing the liver and regulating Qi, harmonizing the stomach to relieve pain, drying dampness and resolving phlegm, resisting arteriosclerosis, protecting tooth health, diminishing inflammation and killing bacteria, nourishing the stomach and treating dysentery and resisting aging. The preparation method of the composition is as follows: the raw materials are dried, ground, extracted, concentrated, granulated and uniformed, so that the fructus citri sarcodactylis-Pu'er tea summer health-care tea is obtained. On one hand, the preparation method is simple and easy to implement and each parameter can be controlled, which is favorable for industrial production; and on the other hand, the prepared composition has a good therapeutic effect, and does not have toxic or side effects.

The invention discloses an anti-deformation embedded block and a forming method for a mold case with a flat bottom plate. The anti-deformation embedded block used for forming a wax mold bottom plate of a single crystal directional vane module comprises a round plate with a flat outer surface, and the round plate is used for being embedded in a wax mold bottom plate forming mold to form a flat forming surface of the wax mold bottom plate. A flowing hole which is throughout a plate body of the round plate and used for mutual flowing of wax materials in an upper cavity and a lower cavity of the round plate and deformation resistance in the solidification process of the wax materials is formed in the round plate. The round plate is further provided with a positioning part used for positioning the round plate when the round plate is embedded in the wax mold bottom plate forming mold. The deformation of the wax mold in the solidification process of the wax materials can be effectively inhibited, deformation of the wax mold caused by surface tension of slurry in the case making process can also be inhibited, and the anti-deformation embedded block and the forming method for the mold case with the flat bottom plate are suitable for single crystal directional vane investment pattern precision casting of various aero-engines and industrial gas turbines.

The invention belongs to the technical field of biological medicines, discloses a miRNA molecule miR-206 for regulating and controlling uterine muscle contraction and application of the miRNA molecule miR-206, and particularly discloses application of miR-206, a precursor of miR-206 and / or a miR-206 simulant to preparation of a medicine for preventing and / or treating premature delivery. The invention discloses miR-206 as a treatment target of premature birth for the first time, the miR-206 is not reported to be related to premature birth before, and the contraction capacity of uterine smooth muscle cells can be remarkably inhibited through overexpression of miR-206, so that the effects of preventing and treating premature birth are achieved, and the morbidity of premature birth and the number of premature infants are reduced.

The invention discloses the application of a cholecystokinin receptor inhibitor-Devazepide in preparation of anti-fibrosis pharmaceutical preparations. The cholecystokinin receptor inhibitor-Devazepide is capable of effectively inhibiting and killing myofibroblast which is closely related to the fibrosis of tissues and organs of a human body and is also capable of inhibiting the contractility of the myofibroblast. On this basis, the cholecystokinin receptor inhibitor-Devazepide is applied to the pharmaceutical preparations used for resisting the myofibroblast and fibrosis, and is used for inhibiting the growth of the myofibroblast and blocking the fibrosis progress.