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Application of common vladimiria root or extract of common vladimiria root in preparing medicines for treating chronic atrophic gastritis

A technology of atrophic gastritis and chuanxiong, which is applied in the field of application of chuanxiang or its extract in the preparation of medicines for treating chronic atrophic gastritis, to achieve obvious effects, inhibit shrinkage, reduce gland atrophy and inflammation The effect of cell infiltration

Inactive Publication Date: 2014-07-30
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant report on the treatment of chronic atrophic gastritis with the single use of Akiras or the combination of extracts of Akiras and seabuckthorn oil

Method used

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  • Application of common vladimiria root or extract of common vladimiria root in preparing medicines for treating chronic atrophic gastritis
  • Application of common vladimiria root or extract of common vladimiria root in preparing medicines for treating chronic atrophic gastritis
  • Application of common vladimiria root or extract of common vladimiria root in preparing medicines for treating chronic atrophic gastritis

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Effect test

Embodiment 1

[0031] The preparation method of embodiment 1 chuanxiong extract

[0032] Grinding Akiras siberiana into coarse powder, using any extraction method of supercritical fluid extraction, solvent ultrasonic extraction, solvent percolation extraction or solvent reflux extraction, to collect Akima chuanxiong extract.

[0033] a. After crushing Akira siberiana into coarse powder, extract and separate it with supercritical fluid carbon dioxide, and dry it under reduced pressure at a temperature below 60°C to obtain the extract of Akira sichuan xiang;

[0034] b. The specific operation of the ultrasonic extraction of the solvent is as follows: after crushing Akiras sinensis into a coarse powder, adding ethanol with a concentration of not less than 85%, after infiltration, extracting by ultrasonic vibration, recovering the solvent under reduced pressure below 60°C, and then using water - Ethyl acetate system extraction, collect the ethyl acetate layer, recover the ethyl acetate under red...

Embodiment 2

[0041] The preparation method of embodiment 2 seabuckthorn oil extract

[0042] Seabuckthorn fruits, seeds, or the mixture of fruits and seeds are crushed, extracted by solvent reflux extraction, supercritical fluid extraction or press centrifugation, and seabuckthorn oil extract is collected.

[0043] Method 1: The solvent method reflux extraction is to crush the seabuckthorn fruit, seeds, or the mixture of fruits and seeds, then solvent method reflux extraction, use n-heptane, heat and reflux extraction twice, each time for 4 hours, and recover Solvent to obtain seabuckthorn oil extract;

[0044] Method 2: The supercritical fluid extraction is to crush the seabuckthorn fruit, seeds, or a mixture of fruits and seeds, and then supercritical CO 2 Fluid extraction, the seabuckthorn oil extract is collected through a primary separator, wherein the extraction pressure is 40MPa, the extraction temperature is 65°C, the extraction flow rate is 18L / h, the primary separation pressure ...

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Abstract

The invention provides application of common vladimiria root or extract of the common vladimiria root in preparing medicines for treating chronic atrophic gastritis and novel application of a medicine composition formed by compatibility of the common vladimiria root or the extract of the common vladimiria root and hippophae rhamnoides or hippophae rhamnoides oil extractive. The common vladimiria root or the extract of the common vladimiria root can promote intestinal peristalsis, restrains contraction effect on smooth muscle caused by acetylcholine, avoids or reduces gland contraction and inflammatory cell infiltration, namely can obviously improve gastrointestinal motility and pathological symptoms of chronic atrophic gastritis, and has good treating effect on the chronic atrophic gastritis caused by autoimmunity or / and bile regurgitation. Simultaneously, the compatibility of the common vladimiria root and hippophae rhamnoides gives play to the synergy effect, the effect in treating the chronic atrophic gastritis is obvious, and the application is a new choice for clinical medication.

Description

technical field [0001] The present invention relates to the new application of cloverwood or its extract. Background technique [0002] Chronic atrophic gastritis (CAG) is a common and intractable disease of the digestive system, and an important precancerous disease of the stomach (the annual canceration rate is 0.5% to 1%). Reduced or disappeared, the clinical manifestations are fullness or pain in the epigastric cavity, heating, noise, loss of appetite, weight loss, etc., which belong to the category of syndromes such as fullness, noise, and stomach pain in traditional Chinese medicine. It has long been believed that the occurrence of chronic atrophic gastritis is the result of the combined effects of various factors, such as Helicobacter pylori infection and peptic ulcer, and it is also related to its activity change and repeated refractory. Reactivity, bile reflux, autoimmunity, genetics, age, high salt and low vitamin diet and other factors are related. [National Dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/289A61P1/04C11B1/04C11B1/06C11B1/10A61K36/185
Inventor 赖先荣孟宪丽张艺
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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