35results about How to "Has antithrombotic effect" patented technology

A preparing method of a perinereis aibuhitensis anticoagulation peptide is disclosed. The method includes steps of (1) sample pretreatment, (2) enzymatic hydrolysis, (3) ultrafiltration, (4) anion exchange chromatography, (5) dextran gel G-25 chromatography, and (6) reversed-phase high-performance liquid chromatography separation and purification to finally obtain the anticoagulation peptide. The method has characteristics of high safety, mild reaction conditions and easy process control. The prepared anticoagulation peptide has high purity, high anticoagulation activity, an antithrombotic function and good medical application value.

The invention discloses a medical component with taurine and medicine to treat blood vessel of brain and heart disease, preparing method and usage in medical technical domain, which is characterized by the following: choosing the blood vessel of brain and heart disease medicine from one or several tanshinone IIA, medical salt, Notoginsen triterpenes, carthamus tinctorius yellow colour, haw leaf total flavone, puerarin and lamp-dish flower element; choosing tanshinone IIA or medical salt as tanshinone IIA mahogany. This invention can used to treat coronary disease, angina pectoris and so on.

The invention discloses a human-mouse chimeric monoclonal antibody against the A3 region of human von Willebrand factor and its preparation method and application. Specifically, the chimeric monoclonal antibody of the present invention includes a murine heavy chain variable region, a murine light chain variable region, a human heavy chain constant region, and a human light chain constant region; wherein the murine heavy chain variable region As shown in SEQ ID NO: 1, the murine light chain variable region is shown in SEQ ID NO: 2, and the human heavy chain constant region is selected from any one of IgG, IgM, IgA, IgE, IgD Chain constant region, the human light chain constant region is any light chain constant region selected from kappa or lambda. The chimeric monoclonal antibody of the present invention can not only inhibit the combination of vWF and collagen, but also inhibit the aggregation of platelets, has a good antithrombotic effect, is not easy to generate anti-mouse immune response in the human body, and greatly reduces the occurrence of clinical bleeding risk .

The invention discloses an antithrombotic biological agent prepared by adopting nereis active peptide. The antithrombotic biological agent is prepared by mixing the following components in parts by weight: 10-20 parts of nereis anticoagulant peptide, 1-5 parts of heparin sodium, and 100 parts of a carrier. The antithrombotic biological agent is good in stability and anticoagulation activity, has the antithrombus function, and has the good medical application value, and the economic additional value of nereis is increased.

The invention discloses hirudo polypeptide with functions of antithrombus and brain nerve cell protection and application of the hirudo polypeptide, and relates to the fields of traditional Chinese medicine, natural medicine and health care products. The structure of the hirudo polypeptide is presented as a formula I, human umbilical vein endothelial cell expressing vascular hemophilia factor (vWF) and a plasminogen activator inhibitor-1(PAI-1) can be significantly lowered at the low concentration of the hirudo polypeptide, the survival rate of nerve cells after oxygen and glucose deprivationis increased, platelet aggregation in vitro is inhibited, the plasma recalcification time is prolonged, formation of thrombi in vivo is reduced, neurobehavior after cerebral infarction of a rat is improved, encephaledema is relieved, the area of cerebral infarction is reduced, the toxicity is low, good application prospects are achieved, and the hirudo polypeptide can be used for preparing medicine or health care products for treating or adjuvant therapy of cardiovascular and cerebrovascular diseases such as atherosclerosis, thrombi and cerebral post-stroke nerve function deficit. The formulaI is NH2-Leu-D-Leu-Ser-Gly-Val-R whitmantide A: R=D-Leu-Gly-COOHwhitmantide B: R=D-Leu-Gly-Gly-COOH whitmantide C: R=COOH.

The invention discloses a perinereis aibuhitensis anticoagulation peptide and use thereof. The amino acid sequence of the perinereis aibuhitensis anticoagulation peptide is Pro-Val-Glu-Arg-Lys. The perinereis aibuhitensis anticoagulation peptide is high in anticoagulation activity, has an antithrombus effect, and has a preferable medical application value.

The invention discloses a method for producing nanometer functional sugar. The method comprises the following steps of crushing and processing raw materials in a crushing tube for 60 to 180 minutes; meanwhile, controlling the rotating speed of a stirring rod to be 2000 to 6000 r / min; in addition, controlling the ultrasonic frequency to be about 30k to 90 k Hz; finally, performing refining for 30 to 120 minutes in an airflow crushing machine; finally, obtaining the nanometer functional sugar with the particle diameter being 20 to 40 nm; controlling the molecular weight distribution of the nanometer functional sugar within 10,000 to 20,000 Da. When the nanometer functional sugar is applied to a hyperglycemic product, after the eating, the blood sugar can be obviously reduced; in the dosage range of 0.5g / kg to 2.0g / kg, the hyperglycemic effect is improved along with the dosage; in addition, the nanometer functional sugar is subjected to sulfuric acid esterification modification; the sulfuric acid esterification derivatives with good water solubility are obtained; the sulfuric acid esterification derivatives have the anticoagulation and antithrombus effects.

The invention provides a traditional Chinese medicine composition for treating tachyarrhythmia, a preparation method and application thereof. The traditional Chinese medicine composition for treating tachyarrhythmia of the present invention comprises the following raw materials in parts by weight: 20-40 parts of Sophora flavescens, 6-30 parts of Zhigancao, 12-15 parts of Fushen, 10-15 parts of American ginseng, 20 parts of Ophiopogon japonicus ‑30 servings, Ejiao 15‑40 servings, Angelica 12‑15 servings and Rehmannia glutinosa 15‑30 servings. The traditional Chinese medicine composition of the invention mainly focuses on nourishing the heart's internal organs and relieving the spirit, supplemented by nourishing the liver, blood and kidney essence, removing blood stasis and regenerating the new generation, and has the functions of slowing down the heart rhythm, inhibiting myocardial ectopic pacemaker, etc. Enhance cardiac systolic function, increase coronary blood flow, improve myocardial ischemia, regulate blood lipids, regulate blood sugar, etc., not only can treat tachyarrhythmias, but also have good effects on common comorbidities such as coronary heart disease, diabetes, and abnormal blood lipid metabolism. regulating effect.

The invention discloses high-purity mannan. The high-purity mannan is produced by beta-mannase controllable enzymolysis of konjak refined powder and is purified to obtain a polysaccharide system of which the weight average molecular weight is 20000-25000Da. After the polysaccharide system is applied to a product for reducing blood glucose, the blood glucose can be obviously reduced by eating the product; and after the polysaccharide system is subjected to derivatization treatment, the polysaccharide system has anti-coagulation and anti-thrombus effects and is an important heparitin raw material.