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Pharmaceutical soft capsule for treating hyperlipemia and its preparation method

A technology of hyperlipidemia and soft capsules, which is applied in the field of medicine, can solve the problems of poor patient compliance, large dosage, and poor curative effect, and achieve the effect of quick onset, small dosage and definite curative effect

Inactive Publication Date: 2006-07-19
刘梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, long-term use of lipid-lowering drugs can cause changes in body lipids, which can lead to the occurrence of non-cardiovascular diseases
[0006] In addition, because cerivastatin (Bestim) caused rhabdomyolysis and death of some patients in European and American countries, on August 8, 2001, the drug manufacturer (Bayer) and the US FDA unanimously agreed to withdraw it. City, the incident has forced a re-examination of the safety of statins
[0007] Significant progress has been made in the treatment of hyperlipidemia by traditional Chinese medicine. At present, the main varieties of traditional Chinese medicine for the treatment of hyperlipidemia in the market are Zhibituo, Xuezhikang, Gypenosides, Evening Primrose Oil, Linoleic Acid, etc., but still Can't meet market needs, and most of them take large doses, slow onset of effect, or poor curative effect, and patients' compliance is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The drug solution of the soft capsule in this example is prepared from the raw materials and auxiliary materials in the following weight ratio: 5.04 parts of Radix Polygoni Multiflori, 5.04 parts of Lycium barbarum, 6.73 parts of Rhizoma Polygonatum, 3.36 parts of Hawthorn, 1 part of Semen Cassiae and 15 parts of polyethylene glycol 400.

[0048] The composition of the soft capsule shell is: 10 parts of gelatin and 4 parts of glycerin.

[0049] The present embodiment soft capsule can be prepared by the method comprising the following steps:

[0050] (1), Extract Polygonatum and Lycium barbarum: Take Polygonatum and Lycium barbarum in the ratio, add 8-12 times the amount of water to decoct and extract 3 times, combine the extracts and concentrate to a relative density of about 1.15, add 95% ethanol until the alcohol concentration reaches about 85%, filter after standing for 12 hours, recover the ethanol from the obtained filtrate, concentrate, then dry into a dry extract...

Embodiment 2

[0055] The medicinal solution of the soft capsule in this example is prepared from the raw materials and auxiliary materials in the following weight proportions: 4.5 parts of Radix Polygoni Multiflori, 5.5 parts of Lycium barbarum, 8 parts of Rhizoma Polygonatum, 3 parts of Hawthorn, 2 parts of Semen Cassiae and 20 parts of propylene glycol.

[0056] The composition of the soft capsule shell is: 10 parts of gelatin and 3 parts of glycerin.

[0057] The present embodiment soft capsule can be prepared by the method comprising the following steps:

[0058] (1), extract Rhizoma Polygonatum and Fructus Lycii: get the Rhizoma Polygonatum and Fructus Lycii of described proportion, add 95% ethanol of 8-12 times amount and reflux extract 3 times, reclaim ethanol after merging the extract, concentrate and dry to a water content less than 5% dry extract to obtain the extracts of Rhizoma Polygonatum and Fructus Lycii;

[0059] (2), extraction of Polygonum multiflorum, Hawthorn and Semen ...

Embodiment 3

[0063] The medicinal solution of the soft capsule in this example is prepared from the raw materials and auxiliary materials in the following weight ratio: 5.5 parts of Radix Polygoni Multiflori, 4 parts of Lycium barbarum, 5.5 parts of Polygonatum, 4.5 parts of Hawthorn, 0.1 part of Semen Cassiae and 5 parts of polyethylene glycol 600, 0.01 part of ethylenediaminetetraacetic acid.

[0064] The composition of the soft capsule shell is: 10 parts of gelatin, 2.5 parts of glycerin and 0.05 part of titanium dioxide.

[0065] The present embodiment soft capsule can be prepared by the method comprising the following steps:

[0066] (1), extract Rhizoma Polygonatum and Fructus Lycii: take the Rhizoma Polygonatum and Fructus Lycium barbarum of said ratio, add 8-12 times the amount of water to decoct and extract 3 times, combine the extracts and concentrate, and then dry to a water content of less than 5%. Dried extract, obtained sealwort and medlar extract;

[0067] (2), extraction ...

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PUM

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Abstract

The invention discloses a medicinal soft capsule for treating hyperlipemia, which comprises capsule fluid and capsule shell, wherein the capsule fluid is prepared from medicinal auxiliary materials and the following raw material medicaments (by weight portions): fleece-flower root 4-6 parts, wolfberry fruit 4-6 parts, Siberian solomonseal rhizome 5.5-8 parts, haw 2.5-4.5 parts, cassia seed 0.1-2 parts, the capsule shell contains 10 parts of gelatin and 2.5-7 parts of glycerin. the invention also discloses the process for preparing the soft capsule.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating hyperlipidemia and a preparation method thereof. Background technique [0002] Hyperlipidemia is a commonly used term for abnormal lipid metabolism, mainly referring to excessive serum total cholesterol (TC) or triglyceride (TG) levels and / or low serum high-density lipoprotein cholesterol (HDL-C) levels. In recent years, with the increase of people's income and continuous improvement of living standards, great changes have taken place in the food structure, and more and more high-protein, high-cholesterol and high-sugar foods are consumed, resulting in a sharp increase in the number of people with hyperlipidemia. According to epidemiological investigations, the prevalence of hyperlipidemia in my country is above 7%, and the general trend is that the north is greater than the south, and the city is greater than the countryside. At present, there are about...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/48A61P3/06
Inventor 刘梅
Owner 刘梅
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