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Application of medicine in preparation of anti-thrombotic medicine

An antithrombotic drug and drug technology, applied in drug combinations, blood diseases, medical formulas, etc., can solve problems such as the application of undisclosed drugs, and achieve significant antithrombotic effects and good therapeutic effects

Inactive Publication Date: 2016-10-12
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent does not disclose the application of the drug in the treatment of thrombotic diseases

Method used

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  • Application of medicine in preparation of anti-thrombotic medicine
  • Application of medicine in preparation of anti-thrombotic medicine
  • Application of medicine in preparation of anti-thrombotic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The medicine tablet that is used for antithrombotic is made up of the crude drug of following weight part:

[0038]

[0039] The preparation method of the medicine tablet comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half the amount of astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to 90 ° C relative density of 1.20 ~ 1.22 paste, mixed with the above powder, made into granules, dried, compressed into 1000 tablets (small tablets), sugar-coated or film-coated tablets, or compressed into 500 tablets ( Large pieces), c...

Embodiment 2

[0042] The drug capsules for antithrombotic are made from the following raw materials:

[0043]

[0044]The preparation method of the drug capsule comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of the astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder, and made into capsules.

[0045] Pharmacodynamic studies have found that the drug of this embodiment has obvious antithrombotic effect, and the thrombus is arte...

Embodiment 3

[0047] The drug granules for antithrombotic are made from the bulk drug in the following parts by weight:

[0048]

[0049] The preparation method of the drug granules comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of astragalus in the raw materials, pulverizing them into fine powder, decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder to make granules.

[0050] Pharmacodynamic studies have found that the drug of this embodiment has obvious antithrombotic effect.

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Abstract

The invention discloses an application of a medicine in preparation of an anti-thrombotic medicine. The medicine is prepared from raw material medicines in parts by weight as follows: 100-150 parts of milkvetch roots, 80-120 parts of pilose asiabell roots, 60-100 parts of danshen roots, 60-100 parts of kudzuvine roots, 60-100 parts of epimedium herbs, 60-100 parts of hawthorn fruits, 40-80 parts of rehmannia roots, 40-80 parts of Chinese angelica, 40-80 parts of rhizoma coptidis, 40-80 parts of vinegar-processed rhizoma corydalis, 40-80 parts of lucid ganoderma, 20-30 parts of ginseng and 20-30 parts of honey-fried liquorice roots. The anti-thrombotic medicine has a good treatment effect, and the rat carotid artery is used for a rat in-vivo thrombus dissolution test; compared with a negative control and a positive control in short time, the medicine has the anti-thrombotic function and has a remarkable anti-thrombotic effect.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular, the invention relates to an application of a medicine in the preparation of an antithrombotic medicine, which belongs to the field of traditional Chinese medicine application. Background technique [0002] Thrombosis is when the blood coagulation system is activated to varying degrees under physiological or pathological conditions, and the formed components in the circulating blood form an embolus in the blood, resulting in partial or complete blockage of the vascular lumen. Corresponding clinical events were acute myocardial infarction, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation. [0003] Under the action of various risk factors (such as vessel wall damage, changes in blood rheology, changes in blood components, etc.), the balance of coagulation and anticoagulation in the systemic coagulation system or local coagulation system in the body is o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P7/02
CPCA61K36/481A61K36/074A61K36/232A61K36/258A61K36/296A61K36/344A61K36/484A61K36/488A61K36/537A61K36/66A61K36/718A61K36/734A61K36/804A61K2236/331A61K2236/39A61K2236/53A61K2236/55A61K2300/00
Inventor 姜作玲王辉洪毅高莉
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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