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Natto kinase composition having antithrombus effect

A nattokinase and antithrombotic technology, which can be used in drug combinations, medical preparations containing active ingredients, enzymes, etc., can solve problems such as decreased activity, and achieve the effects of increasing blood vessel elasticity, good stability, and preventing thrombosis.

Inactive Publication Date: 2018-05-15
阮小军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nattokinase is a single-chain polypeptide enzyme with a molecular weight of about 30kDa and an isoelectric point of about 8.5. It has rich activity in the range of pH 7-12, but under acidic conditions, when the pH is lower than 5.0 rapid decrease in activity

Method used

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  • Natto kinase composition having antithrombus effect
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The nattokinase composition with antithrombotic effect is prepared from the following raw materials in parts by weight:

[0058] 10.45 parts of nattokinase, 85 parts of maltodextrin, 0.025 parts of flavoring material, and 0.25 part of flavoring agent. The flavoring material is lemon essence, and the flavoring agent is sucralose.

[0059] The preparation method of the above-mentioned nattokinase composition with antithrombotic effect is as follows: each raw material is weighed by weight and mixed uniformly to obtain the nattokinase composition with antithrombotic effect.

Embodiment 2

[0061] The nattokinase composition with antithrombotic effect is prepared from the following raw materials in parts by weight:

[0062] 10.45 parts of nattokinase, 85 parts of maltodextrin, 0.025 parts of flavoring agent, 0.25 parts of flavoring agent, 0.1 part of astragalus extract, 0.25 parts of salvia miltiorrhiza extract, 0.15 parts of matsutake extract, 0.15 parts of Gastrodia elata extract, Cyperus cyperus extract 0.05 parts. The flavoring material is lemon essence, and the flavoring agent is sucralose.

[0063] The preparation method of the described astragalus extract is as follows: crush astragalus and pass through a 50-mesh sieve to obtain astragalus powder, add 300 g of astragalus powder to 1500 g of ethanol aqueous solution with a mass fraction of 85%, and heat at 70° C. in a water bath at 150 rpm Stir at a speed of 1 / min for 24 hours, pass through a 200-mesh sieve, evaporate and concentrate the filtrate to obtain a thick paste with a relative density of 1.25 meas...

Embodiment 3

[0070] The nattokinase composition with antithrombotic effect is prepared from the following raw materials in parts by weight:

[0071] 10.45 parts of nattokinase, 85 parts of maltodextrin, 0.025 parts of flavoring agent, 0.25 parts of flavoring agent, 0.15 parts of astragalus extract, 0.05 parts of salvia miltiorrhiza extract, 0.2 parts of matsutake extract, 0.2 parts of Gastrodia elata extract, Cyperus cyperus extract 0.1 parts. The flavoring material is lemon essence, and the flavoring agent is sucralose.

[0072] The preparation method of Astragalus extract, Salvia miltiorrhiza extract, Matsutake extract, Gastrodia elata extract and Rhizoma Cyperus extract are the same as in Example 2.

[0073] The preparation method of the above-mentioned nattokinase composition with antithrombotic effect is as follows: each raw material is weighed by weight and mixed uniformly to obtain the nattokinase composition with antithrombotic effect.

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Abstract

The invention provides a natto kinase composition having antithrombus effect, a preparation method, and an application thereof in healthcare foods having thrombus prevention effect. The natto kinase composition is prepared from: natto kinase, maltodextrin, a spice and a corrective agent. The natto kinase composition has antithrombus effect, is safe and is free of toxic and side effects, has good stability, has functions of preventing thrombogenesis, dissolving the thrombus, reducing blood viscosity and improving blood circulation, and softening blood vessels and increasing elasticity thereof,and is suitable for various healthcare foods.

Description

technical field [0001] The invention relates to a composition containing nattokinase. Background technique [0002] Nattokinase, nattokinase is a kind of serine protease with fibrinolytic activity, which was extracted and discovered by Japanese Sumi detailed line in 1987 in natto, a traditional Japanese product. The study found that nattokinase can produce physiologically active substances during the fermentation process of natto, and has been valued by researchers because of its ability to dissolve blood clots. Nattokinase can not only directly act on fibrin in the body to reduce the content of fibrinogen, but also activate t-PA in the body, showing a strong thrombolytic effect, and nattokinase has a fast onset and long drug effect. advantage. Nattokinase has a good thrombolytic effect both in vitro and in vivo; when the extract of nattokinase is mixed with thrombin-containing components, thrombin can be dissolved, which proves that nattokinase has a good thrombolytic eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P7/02A23L33/00
CPCA23V2002/00A61K36/07A61K36/481A61K36/537A61K36/8905A61K36/8988A61K38/482C12Y304/21062A61K2300/00A23V2200/326
Inventor 阮小军
Owner 阮小军
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