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Compound hippopha flavone Chinese medicine for preventing and treating blood deficiency brain blood vessel disease and its preparation technology

A technology for cerebrovascular disease and acesacoflavone, which is applied in the field of acesaclavone compound traditional Chinese medicine composition prescription and preparation technology, and can solve the problems of unstable effect, less precise curative effect, insufficient effect and the like

Inactive Publication Date: 2006-06-14
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs used to treat such diseases clinically generally use tube expansion agents, such as papaverine, nimodipine or dextran, etc., or anticoagulants such as dipyridamole, aspirin and other western medicines, and some traditional Chinese medicines for promoting blood circulation and removing blood stasis, such as salvia miltiorrhiza and ligustrazine. etc.; but either the curative effect is inaccurate, the onset of effect is slow, the effect is unstable, or the side effects such as gastrointestinal bleeding and other reasons are also limited in clinical application
Ginkgo biloba extract and its preparations are also used clinically, but the effect is weak, the effect is not significant enough, and the onset of effect is also slow

Method used

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Examples

Experimental program
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Effect test

example 1

[0007] Take 1000 g of dried seabuckthorn and grind it into coarse powder, squeeze the oil, extract with 10 L of 85% ethanol under reflux four times, each time for 2-3 hours, filter, combine the filtrates, recover the ethanol, and concentrate to dryness. Squeeze the oil again (or degrease with gasoline or petroleum ether), heat and reflux with 0.3 L of ethanol to extract, evaporate the ethanol, concentrate to a dry paste, wash with 0.1 L of water, and dry to obtain the seabuckthorn extract for later use. Calculated on the dry basis, containing total flavonoids i.e. acetaloflavone and isorhamnetin (C 16 h 12 O 7 ), should be 10.0% to 14.0%.

[0008] Take 1000g of green tea, add 10L of water, heat and decoct for 50 minutes, filter, add saturated lime water to the filtrate after cooling, adjust the pH value of the filtrate to 9, let it stand, filter, take the precipitate and dissolve it with 10% hydrochloric acid, and then adjust the pH value to 4, let it stand for a while, and...

example 2

[0011] Take 1000g of the above-mentioned seabuckthorn extract (acetaloflavone), 200g of tea extract, 150g of ginkgo extract, add 200g of microcrystalline cellulose (dried at 80-100°C for 4 hours), 220g of starch, granulate with 45% ethanol, and granulate at low temperature. After drying, 1.5 g of magnesium stearate was added, mixed evenly, compressed into tablets, and coated. (Each tablet of the obtained product contains 2 mg to 16 mg of acetaloflavones in terms of isorhamnetin; 6 to 12 percent of ginkgo flavonoids, and 33 to 80 percent of tea polyphenols.)

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PUM

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Abstract

A Chinese medicine in the form of mixture, dripping pill, particle, oral liquid, tablet, capsule, or injection for preventing and treating ischemic cerebrovascular diseases such as cerebral arteriosclerosis, hpyomnesia, dizziness, cerebral ischemia, cerebral infarction, etc is prepared from seabuckthorn fruit, ginkgo leaf, tea leaf and auxiliary through extracting.

Description

【Technical field】 [0001] The invention relates to the technical field of traditional Chinese medicines, and relates to a prescription of a compound Chinese medicine composition of acetaloflavone (seabuckthorn extract) for preventing and treating ischemic cerebrovascular diseases and a preparation process thereof. 【Background technique】 [0002] Ischemic cerebrovascular disease (cerebrovascular disease) is a common and frequently-occurring disease in clinical practice, and its incidence rate is increasing year by year, and there is a clear trend of younger people. According to relevant statistics, in the current ranking of the mortality rate of various diseases in the country, cerebral apoplexy has leapt to the first place. There are about 1.5 million new cases of stroke in my country every year, and about 1 million people die from stroke. Such diseases include transient ischemic attack and formation of cerebral thrombosis, such as arteriosclerotic cerebral infarction, cereb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 冀广沁邓聪支春周旋徐琨
Owner SICHUAN GUOKANG PHARMA
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