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Functional sugar prepared based on nanotechnology and its application in the field of medicine

A nano-functional and frequency-controlled technology, which can be used in pharmaceutical formulations, drug combinations, and medical preparations containing active ingredients, and can solve problems such as high drug prices.

Active Publication Date: 2020-06-05
NINGBO BAIERMA BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to unhealthy eating habits and living habits of human beings, most people's blood sugar is getting higher and higher, requiring drug treatment, and drug treatment basically has adverse reactions, and the price of drugs is relatively expensive

Method used

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  • Functional sugar prepared based on nanotechnology and its application in the field of medicine
  • Functional sugar prepared based on nanotechnology and its application in the field of medicine
  • Functional sugar prepared based on nanotechnology and its application in the field of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0028] Experimental method: Select 100 Kunming adult mice (half male and half male), with an average body weight of (25±2.5) g, randomly select 10 mice as the normal control group according to the principle of equal male and female, and feed the remaining 40 mice with high-fat diet for 2 -3 months later, small doses of streptozotocin were used to induce diabetes, and those whose fasting blood glucose value was greater than 15mmol / L were included in the experiment, and then the mice were randomly divided into a type 2 diabetes model group, a metformin administration group, and mannan The low-dose group (0.5g / kg), the high-dose mannosidan group (2.0g / kg), the normal control group and the type 2 diabetes model group were given the same amount of distilled water. The experimental period was 4 weeks, and blood was collected from the orbits of mice in each group on an empty stomach every other week to measure their blood sugar levels.

[0029] The specific test results are shown in ...

Embodiment example 2

[0035] Select 48 Kunming adult mice (half male and half female) with an average body weight of (25±2.5) g, and randomly divide them into 4 groups with 12 mice in each group. According to the volume of 25ml / kg, they were given normal saline, 10mg / kg of warfarin, 10mg / kg of low dose of mannan derivatives, and 1000g / kg of high dose of mannan derivatives, respectively, for 30 days. One hour after the administration on the 30th day, blood was collected from the venous plexus behind the inner canthus of the mouse eyes, and the coagulation time of the mice in each group was measured according to the capillary method: the blood was taken until the blood column was 5 cm high, and a section of the capillary was broken every 30 seconds to check whether there was coagulation The coagulation time is the elapsed time from the beginning of blood collection to the appearance of coagulation filaments.

[0036] Table 2 Effects of mannan derivatives on blood coagulation time in mice

[0037] ...

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Abstract

The invention discloses a method for producing nanometer functional sugar. The method comprises the following steps of crushing and processing raw materials in a crushing tube for 60 to 180 minutes; meanwhile, controlling the rotating speed of a stirring rod to be 2000 to 6000 r / min; in addition, controlling the ultrasonic frequency to be about 30k to 90 k Hz; finally, performing refining for 30 to 120 minutes in an airflow crushing machine; finally, obtaining the nanometer functional sugar with the particle diameter being 20 to 40 nm; controlling the molecular weight distribution of the nanometer functional sugar within 10,000 to 20,000 Da. When the nanometer functional sugar is applied to a hyperglycemic product, after the eating, the blood sugar can be obviously reduced; in the dosage range of 0.5g / kg to 2.0g / kg, the hyperglycemic effect is improved along with the dosage; in addition, the nanometer functional sugar is subjected to sulfuric acid esterification modification; the sulfuric acid esterification derivatives with good water solubility are obtained; the sulfuric acid esterification derivatives have the anticoagulation and antithrombus effects.

Description

technical field [0001] The invention relates to a nanometer refinement technology, and also relates to the functional sugar prepared by the technology and its application in medicine. Background technique [0002] Nanometer (English: nanometre) is a unit of length, and the SI symbol is nm. Originally known as nanometers, it is 10 -9 Meter (one billionth of a meter), that is, 10 -6 mm (1,000,000th of a millimeter). Like centimeters, decimeters, and meters, a unit of measure for length. That's four times the size of an atom and smaller than the length of a single bacterium. The international common name is nanometer, abbreviated as nm. [0003] Current scientific research shows that the particle size of particles will affect the distribution of drugs in the body. Particles with a particle size of <5 μm can pass through the lungs, particles with a particle size of <300nm can enter the blood circulation, and particles with a particle size of <100nm can enter the bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/736A61P3/10A61P7/02
CPCA61K31/736C08B37/009
Inventor 钱金宏卢晓会钱杰瑞钱乾黄代勇
Owner NINGBO BAIERMA BIOLOGICAL TECH CO LTD
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