The invention discloses a nontoxic calcium and zinc thermal stabilizer, which comprises the following matters: a primary calcium and zinc stabilizer, a diketone, a polyol, an external lubricating agent, an internal lubricating agent and an antioxygen. Compared with the prior art, the one-pot-process chemical mixing for synthesizing a calcium and zinc salt, which is mixing on a molecular level, has better synergetic effect than physical mixing; the introduction of another anionic benzoic acid on the basis of one anionic stearic acid greatly improves the processing properties of the stabilizer,such as lubricating property, transparent property and compatibility; without any toxic components, the mixture is really nontoxic and environment-friendly; the prepared thermal stabilizer has high static performance, dynamic performance and color constancy; and at 180 DEG C, the congo red time is more than 120 minutes, and the white difference delta E between two rolled pieces is less than 2. The production process is simple and the cost is low.