35 results about "Tongue Cancers" patented technology

The invention provides a novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof and particularly relates to application of a KLK14 gene and an expression product thereof to diagnosis and treatment of tongue squamous carcinoma. To research the occurrence and development mechanisms of tongue squamous carcinoma, search for an effective molecular target gene for diagnosing and treating tongue squamous carcinoma, promote early diagnosis, prevention and treatment of the disease and lower the death rate of tongue cancer, firstly, RNA-seq sequencing is utilized to detect differential expression genes of tongue squamous carcinoma, cancer branch and normal oral mucosa; secondly, a Real-time PCR technology is utilized to verify the sequencing result; then, an interference technology is utilized, and expression of the candidate gene KLK14 in tongue squamous carcinoma cells SCC15 is silenced. By means of the novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof, an experimental foundation is laid for clinical application of the KLK14 gene to tongue squamous carcinoma, and a new target gene and theoretical basis are provided for early diagnosis and treatment of tongue squamous carcinoma.

The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological evaluation.

The invention discloses a usage of Jew ear fungal aqueous extract in the preparation of a drug for curing tumors, wherein, the tumors include cervical cancer, ovarian cancer, carcinoma of endometrium, vulva cancer, prostate cancer, parotid gland, thyroid cancer, salivary gland cancer, skin cancer, nasopharyngeal carcinoma, tongue cancer, oral cavity cancer, carcinoma of larynx, encephaloma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, testicular cancer, penile cancer, multiple myeloma and / or malignant melanoma.

The invention discloses a radioactive anion resin microsphere and a method for preparing the same, and belongs to the technical field of medicines. The radioactive anion resin microsphere is prepared by curing anionic radionuclide in the anion resin of which the diameter is 5 to 200 mu m and the crosslinking degree is 1 to 20 percent in a precipitation mode. The preparation method comprises the following steps of exchanging the anions of radionuclide to the anion resin, making the radionuclide in the anion resin react with a metal cation precipitator in a solution to form a precipitation in the resin, further curing the radionuclide in the resin and preparing the anion resin microsphere of P-32, I-125, I-131, Re-186 or Re-188. The novel radioactive resin microsphere using anion resin microspheres as a carrier has the characteristics of low release rate of radionuclide, high safety, simple preparation process and the like. The radioactive anion resin microsphere can be used for treating malignant tumors such as liver cancer, lung cancer, tongue cancer and the like.

The invention discloses a radioactive particle chain connected by controllable and fast degradable magnesium and a magnesium alloy and belongs to the field of medical devices implanted in bodies. The radioactive particle chain with certain length is prepared by connecting the controllable and fast degradable magnesium, the magnesium alloy 1 and radioactive particles 2 through welding at certain distances. The radioactive particles have the therapeutical effect, and the magnesium and the magnesium alloy are used as connecting materials, so that the radioactive particle chain comprises unique controllable and fast degradation characteristics. The radioactive particle chain has the functions of ensuring uniform distribution of the particles, preventing the particles wandering, and reducing distances among the particles with reduction of tumors and making the particles uniformly distributed on focuses all the time when the particle chain is degraded after being implanted for 1 to 2 months. The radioactive particle chain is suitable for curing extensive diseases such as intracranial tumors, nasopharyngeal carcinoma, oropharyngeal carcinoma, tongue cancer, cervical metastatic tumors, lung cancer, breast cancer, pancreatic cancer, cholangiocarcinoma, liver cancer, prostate cancer, gynecological tumors, and soft tissue and bone tumors.

The invention discloses a radioactive particle chain connected by a controlled degradable magnesium and magnesium alloy pipe, which belongs to the field of medical appliance implanted to an organism. The radioactive particles 2 are connected by the controlled degradable magnesium and ultra-thin magnesium alloy pipe 1 at a certain interval. In the invention, the radioactive particle plays a treatment role, and the magnesium and magnesium alloy pipe acts as a connecting material. Due to controllable rapid degradation characteristics, the radioactive particle chain can ensure uniform distribution of particles and prevent particles from wandering. The chain is degradable after being implanted for one week to one month, so that the interval between particles can be reduced with the shrinking of a tumor to uniformly distribute the particles within a lesion. The radioactive particle chain of the invention can be used for treating extensive diseases, which mainly comprise intracranial tumor, nasopharyngeal carcinoma, oropharyngeal cancer, tongue cancer, neck metastases, lung cancer, breast cancer, pancreatic cancer, cholangiocarcinoma, liver cancer, prostate cancer, gynecological tumor, soft tissue and bone tumor.

Devices and methods can be used for performing transoral surgery. For example, this document provides oral retractor devices and articulating surgical tools that are well-suited for transoral surgery uses. The devices and methods provided herein may be used to treat conditions such as, but not limited to, mouth cancer, throat cancer, tongue cancer, larynx cancer, tonsil cancer, obstructive sleep disorders, and pharyngeal diverticulum, to provide some examples.

The invention discloses an application of Hsp27 in tolerance diagnosis and treatment for tongue cancer chemotherapy. The conditions that the Hsp27 protein level in a tongue cancer cell culture supernatant and the Hsp27 protein level in serum of a tongue cancer patient can be raised through chemotherapeutic drug treatment and expression of the Hsp27 in a tolerance cell for tongue cancer chemotherapy is higher than that in a sensitive cell are verified for the first time; and the chemosensitivity of a drug-resistant cell is improved by interfering with and lowering the expression of the Hsp27 and the chemotherapy tolerance of the tongue cancer cell is improved through overexpression of the Hsp27. New data is provided for research on a tolerance mechanism for tongue cancer chemotherapy, a new detection marker is provided for prediction of the tongue cancer chemosensitivity, and a theoretical basis is provided for development of a new treatment strategy based on the Hsp27 as a target.

The invention relates to a method of producing a pharmaceutical composition, consisting in mixing nitric acid in composition with mucin and ptyalin enzymes which are used as absorbers. Together, said components produce a topical aqueous solution which destroys pathogenic tissue, by coagulating same, in order to treat a patient with warts, verrucas, skin cancer, tongue cancer, throat cancer, ulcerated tonsils, gingivitis, streptococcus or staphylococcus in the throat, uterine cervix cancer or fungus. The inventive composition can also be applied to any part of the skin or mucous membranes. Said composition is administered topically (externally) in one, two, three or four applications depending on the severity of the infection or wound. More specifically, the invention relates to a pharmaceutical composition comprising an effective quantity of nitric acid, mucin and ptyalin and distilled water which is used as an acceptable pharmaceutical vehicle or carrier. The composition is selective given that it strangulates the pathogenic tissue until said tissue is destroyed, leaving the healthy tissue intact apart from a slight mark which is caused by the effects of the nitric acid.

The invention provides a tongue cancer postoperative defect tongue body reconstruction method and system, a readable storage medium and equipment, and the reconstruction method comprises the steps: obtaining a tongue body three-dimensional surface grid model through three-dimensional reconstruction; selecting mark points on the surface of the cutting area in the three-dimensional surface grid model of the tongue body, wherein the mark points comprise the lowest point of the cut-off area, the highest point of the cut-off area, two mark points on the front area boundary of the cut-off area, the mark points on the side area boundary of the cut-off area and the mark points on the back area boundary of the cut-off area; on the basis of the selected mark points, fitting a curved surface of the cut-off area; unfolding the curved surface of the excision area to obtain an unfolded surface of the excision area; and measuring the physical parameters of the unfolded surface. According to the invention, the mark points are taken from the reconstructed tongue model, the fitting surface of the resection range of the tongue body is established, and the fitting curved surface is extended into a plane to obtain the area and the contour range of the skin flap to be resected, so that the planning is more consistent with the individualization, and the failure rate of the operation is reduced.

The invention relates to the field of animal models and particularly discloses an establishment method for a model for promoting tongue cancer development and lymphatic metastasis of mammals. According to the establishment method for the model for promoting tongue cancer development and lymphatic metastasis of the mammals, the mammals are fed with a 4-NQO solution and a NaNO2 solution in sequence for a period of time; the mammals are subjected to normal observation every week and killed randomly for HE staining observation and immunohistochemistry CK8 staining observation; when white patches are generated on the tongue faces of the mammals, invasive carcinoma is found through HE staining observation, and lymphatic metastasis is generated through CK8 staining. The establishment method for the animal model for promoting tongue cancer development and lymphatic metastasis with sodium nitrite is established, the progress of the actually-generated tongue cancer is simulated, and a novel and powerful tool is provided for research on the influences of sodium nitrite on the tongue cancer, treatment research on the tongue cancer and the like.

The invention discloses a radioactive anion resin microsphere and a preparation method (1) thereof and belongs to the technical field of medicines. The radioactive anion resin microsphere is formed by solidifying cation radionuclide in anion resin with the diameter of 5 mu m-200mu m and crosslinking degree of 1%-2% in a sediment mode. The preparation method of the radioactive anion resin microsphere comprises exchanging a non-radioactive anion precipitant into the anion resin, adding the obtained anion resin into solution containing cation radionuclide, enabling the cation radionuclide in the solution to react with the anion precipitant adsorbed in the resin to form sediments, enabling the radionuclide to be solidified in the resin, and preparing the radioactive anion resin microsphere. The radioactive anion resin microsphere has the advantages of being low in radionuclide release rate, high in safety and simple in preparation process and the like. The radioactive anion resin microsphere can be used for curing malignant tumors such as liver cancer, lung cancer and tongue cancer.

The invention discloses a method for preparing and marking bcl-2 protein of oral squamous cell carcinoma cells through an imine acridine fluorescent probe. Imine acridine is applied to performing fluorescence marking on the bcl-2 protein of the oral squamous cell carcinoma cells and compared on photostability with Fluorescein insothiocyanate (FITC) marks. The applied imine acridine fluorescent probe technically has the advantages that the imine acridine fluorescent probe can reach a maximum emission wavelength of 470 nm under a fluorescence microscope, viewed under a fluorescence inversion microscope, the imine acridine fluorescent probe can clearly mark the bcl-2 protein in tongue cancer ca8113 cells; the method for preparing and marking the bcl-2 protein of the oral squamous cell carcinoma cells through the imine acridine fluorescent probe is high in sensitivity, simple rapid and accurate and is superior to traditional FITC marking methods.

The present invention discloses one new medical application of ursolic acid. Ursolic acid distributed widely in plant has several bioactivities and obvious effect of killing and inhibiting deformed streptococcus, periodontal pathogenic bacteria and oral cavity tongue cancer cell. Therefore, it may be used as effective component in prepairng sanitary article, health product and disease treating medicine for oral cavity. The present invention opens a new way for oral health and oral disease treatment by using the rice plant resource.

The invention relates to a traditional Chinese medicine composition for treating tongue cancer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following Chinese herb raw materials by weight: 5-10g of berberis thunbergii, 5-10g of asiatic pennywort herb, 3-9g of Indian strawberry root, 5-15g of radix scrophulariae, 5-10g of clausena lansium, 5-10g of kumquat kernel, 3-6g of melastoma dode candrum lour root, 3-8g of lichen of parmelia saxitilis, 5-9g of lalang grass rhizome and 5-10g of Chinese fevervine herb. The traditional Chinese medicine composition can be prepared into pills, capsules and a decoction. The berberis thunbergii, the asiatic pennywort herb, the Indian strawberry root and the radix scrophulariae are capable of clearing internal heat and detoxifying; the clausena lansium and the kumquat kernel are capable of dissipating stasis and stopping pain; the melastoma dode candrum lour root, the lichen of parmelia saxitilis, the lalang grass rhizome and the Chinese fevervine herb are capable of enriching blood and tonifying qi; the various medicinal materials are combined to have an exact curative effect on the tongue cancer without toxic or side effects; the traditional Chinese medicine composition is also effective for oral cancers such as gingiva cancer, oropharyngeal cancer and lip cancer.

The invention discloses a preparation method of a traditional Chinese medicine preparation for treating tongue cancer. The traditional Chinese medicine preparation comprises the following raw material medicinal materials: common dysosmatis rhizome and root, wolfberry leaves, plantain herb, Indian aeginetia herb, herb of korsakow monochoria, siam psychotria herb, pilose asiabell root, pinellia tuber, scorpion, stinkweed, Yunnan manyleaf Paris rhizome, Mongolian dandelion herb, coix seeds, rhizoma coptidis, watermelon peel, amur corktree bark, gecko, rhizoma corydalis, toad venom, ivy-like merremia and largehead atractylodes rhizome. The dosage form of the traditional Chinese medicine is capsules. The specific preparation process is as follows: mixing the raw material medicinal materials according to the proportion, drying in an environment at the temperature of 60 DEG C, removing impurities and then placing to cool; grinding the dried materials to particles, then screening by a 60-90mesh sieve, uniformly mixing and then continuously removing the impurities for later use; continuously grinding the particles into powder, screening by a 100-120mesh sieve, then performing ultraviolet disinfection and loading into capsules according to 0.6g / capsule to obtain a finished product. Compared with the prior art, the traditional Chinese medicine preparation has the effects of clearing heat and toxin, cooling and dissipating wind heat, reducing swelling, relieving pain, inducing resuscitation, sterilizing, eliminating maculas and removing a focus and has relatively strong pertinence.

A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of Paroxetine or a pharmaceutical acceptable salt thereof. The cancer is selected from the group consisting of pleural-related cancer, abdominal-related cancer, endocrine-related cancer, gastrointestinal tract-related cancer, osteosarcoma, skin cancer, and blood cancer. The pleural-related cancer is lung cancer. The abdominal-related cancer is selected from bladder cancer, cervical cancer, and kidney cancer. The endocrine-related cancer is selected from prostate cancer, breast cancer, and ovarian cancer. The gastrointestinal tract-related cancer is selected from gastric cancer, hepatic cancer, colorectal cancer, pancreatic cancer, and tongue cancer.

The invention provides application of doxycycline in preparing antitumor drugs, wherein the tumor contains one or a combination of more of tongue cancer, laryngeal cancer, choriocarcinoma, sialaden tumor, gallbladder carcinoma and thymoma. In the application, doxycycline can be used as the drug for inhibiting tumor growth as well as the drug for inhibiting tumor metastasis. The drug can be easilyaccepted by patients, is low-cost, is extensive in source, can be easily acquired and is convenient for understanding the reaction of patients to the drug. Besides, doxycycline will change the existing market structure of tumor chemotherapeutic drugs and can become a clinical drug suitable for long-term administration and capable of effectively inhibiting tumor metastasis, invasion and relapse.

The invention provides a black garlic extract which is prepared by the following steps that black garlic slices are taken, water with the weight of 3-6 times of that of black garlic is added to the black garlic, extraction is performed at the temperature of 85 DEG C to 115 DEG C by 2-4 parts, the mixture is filtered, first filtrate is collected, and filter residue is kept; water with the weight of 1-2 times of that of black garlic is added to the filter residue, composite plant hydrolases with the weight of 0.003-0.05 time of that of black garlic is added to the mixture, enzymolysis is performed, 60%-80% of ethanol solution with the weight of 1-3 times of that of black garlic is added, heating reflux extraction is performed by 3-6 h, filtering is performed to take filtrate, decompress concentration is performed, and second filtrate is obtained after ethyl alcohol removal; the first filtrate and the second filtrate are combined, and the black garlic extract is obtained after mixing. The black garlic extract has an inhibiting effect on growth of the tongue cancer Tc-8113 cell line and can be used for preventing and curing tongue cancer.

The invention provides a series of peptides for resisting tongue cancer and a method for extracting the peptide. The series of peptides are higher in stability and capacity for suppressing growth of tongue cancer cells. The peptides can be used for treating cancers.

The invention discloses composition having effects of clearing heat and removing toxins. The composition is prepared from raw materials in parts by weight as follows: 15-20 parts of loquat leaves, 15-20 parts of prepared rehmannia roots, 10-15 parts of dried rehmannia roots, 10-15 parts of dwarf lilyturf tubers, 10-15 parts of cochinchinese asparagus roots, 10-17 parts of immature bitter oranges, 8-10 parts of virgate wormwood herbs, 8-13 parts of dendrobium nobile, 10-15 parts of liquorice roots and 10-13 parts of baical skullcap roots. The composition has effects of clearing heat and removing toxins, has functions of removing internal heat of stomach and intestines, activating blood and invigorating the stomach, is used for treating stasis-heat in the stomach, bad breath, sore throat, sores in mouths, oral ulcer, gingival abscess, pharyngolaryngitis, tongue cancer, scurvy, jaundice and the like, has a heat clearing and detoxication function on chronic stomatitis, oral ulcer and perioral cellulitis and has the curative effect commonly superior to that of a conventional anti-bacterial and anti-inflammatory drug.

The invention discloses a method for establishing a model of a large animal tumor lymph node high-metastasis model and rapidly detecting the lymph node containing tumor cells in real time. The methodcomprises the following steps: establishing a rabbit tongue tumor model, and establishing a rabbit cervical lymph node high-metastasis model based on the rabbit tongue tumor model; after successful establishment of the rabbit cervical high-metastasis model, an endogenous substance 5-aminolevulinic acid (5-ALA) is used, and the fluorescence of its metabolite protoporphyrin (PPIX) is used to rapidlyand accurately detect the rabbit cervical lymph node. The method has the advantages of simple operation and high reliability, fully and completely simulates the clinical characteristics and biological characteristics of human tongue cancer lymph node metastasis, provides a research model for the treatment and resection of lymph node metastasis of human tumors, provides a novel means for intraoperative visualization of real-time tumor lymph node dissection, and has broad application prospects in the fields of biomedical and photodynamic diagnosis.

The invention discloses a pharmaceutical composition for treating tongue cancer and laryngocarcinoma. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 12-24 parts of cynanchum paniculatum, 12-24 parts of solanum lyratum, 12-24 parts of mock-strawberry, 12-24 parts of sapindus mukorossi gaertn root, 12-24 parts of Chinese actinidia root, 12-24 parts of pseudo-ginseng, 12-24 parts of ginseng, 12-24 parts of astragalus membranaceus, 12-24 parts of desert cistanche, 12-24 parts of nightshade, 12-24 parts of spina gleditsiae, 12-24 parts of indigo naturalis, 12-24 parts of air potato, 9-21parts of calculus bovis factitious, 9-21parts of subprostrate sophora, 9-21parts of calomel, 9-21parts of musk, 9-21parts of borneol, 9-21parts of salviae miltiorrhizae and 9-21parts of talcum powder, the raw materials are combined to active components, the pharmaceutical composition has a good curative effect on tongue cancer and laryngocarcinoma. The invention further discloses use of the pharmaceutical composition.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to an application of antitussive and antiasthmatic tablets containing bulbophyllum in preparation of drugs for inhibiting proliferation of human tongue cancer cells TCA 8113 as well as a preparation method of the antitussive and antiasthmatic tablets containing bulbophyllum. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared from raw material medicines including 200 g of bulbophyllum, 200 g of Chinese fevervine herbs, 100 g of leatherleaf mahonia stems, 100 g of marsdenia tenacissima, 100 g of common bletilla pseudobulb, 100 g of giant knotweed rhizomes, 100 g of garden balsam stems and 100 g of manyflower solomonseal rhizomes. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared through supercritical extraction, so that the content of rheum emodin is greatly increased.

The invention relates to an application of a secretory protein 1 rich in cysteine in preparation of a medical apparatus for diagnosing tongue cancer. The medical apparatus is diagnostic test paper or a kit. The diagnostic sample of the medical apparatus is saliva. The invention has the advantages that a novel use of the secretory protein 1 rich in cysteine is provided, and a convenient, reliable, noninvasive and cheap method for screening crowds in a large scale with tongue cancer and self-detection of postoperative patients with tongue cancer is provided for guiding treatment of tongue cancer. The test paper provided by the invention is fast in detection, high in sensitivity, strong in specificity, good in stability, simpleness and convenience in operation, and no any instruments and devices. The result is intuitive and reliable to judge and easy to master, and the patient can conveniently monitor the own condition.

The invention relates to application of bostrycin. Researches of the invention show that the bostrycin is capable remarkably inhibiting proliferation and migration of tongue cancer cells, retarding the cycles of the cell in a G2 / M stage and causing potential change of a mitochondrial membrane, so as to cause apoptosis. According to the bostrycin, the potential change of the mitochondrial membraneand increase of BAX expression are induced, and cell apoptosis is induced by inducing a mitochondria apoptosis pathway, so that growth of the tongue cancer cells is inhibited.

The invention discloses a radioactive anion resin microsphere and a method for preparing the same, and belongs to the technical field of medicines. The radioactive anion resin microsphere is prepared by curing anionic radionuclide in the anion resin of which the diameter is 5 to 200 mu m and the crosslinking degree is 1 to 20 percent in a precipitation mode. The preparation method comprises the following steps of exchanging the anions of radionuclide to the anion resin, making the radionuclide in the anion resin react with a metal cation precipitator in a solution to form a precipitation in the resin, further curing the radionuclide in the resin and preparing the anion resin microsphere of P-32, I-125, I-131, Re-186 or Re-188. The novel radioactive resin microsphere using anion resin microspheres as a carrier has the characteristics of low release rate of radionuclide, high safety, simple preparation process and the like. The radioactive anion resin microsphere can be used for treating malignant tumors such as liver cancer, lung cancer, tongue cancer and the like.

The invention provides a novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof and particularly relates to application of a KLK14 gene and an expression product thereof to diagnosis and treatment of tongue squamous carcinoma. To research the occurrence and development mechanisms of tongue squamous carcinoma, search for an effective molecular target gene for diagnosing and treating tongue squamous carcinoma, promote early diagnosis, prevention and treatment of the disease and lower the death rate of tongue cancer, firstly, RNA-seq sequencing is utilized to detect differential expression genes of tongue squamous carcinoma, cancer branch and normal oral mucosa; secondly, a Real-time PCR technology is utilized to verify the sequencing result; then, an interference technology is utilized, and expression of the candidate gene KLK14 in tongue squamous carcinoma cells SCC15 is silenced. By means of the novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof, an experimental foundation is laid for clinical application of the KLK14 gene to tongue squamous carcinoma, and a new target gene and theoretical basis are provided for early diagnosis and treatment of tongue squamous carcinoma.