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35 results about "Tongue Cancers" patented technology
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Novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof
ActiveCN105779618AHigh selectivitySimplify the process of quantitative detectionOrganic active ingredientsGenetic material ingredientsDiseaseCandidate Gene Association Study
The invention provides a novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof and particularly relates to application of a KLK14 gene and an expression product thereof to diagnosis and treatment of tongue squamous carcinoma. To research the occurrence and development mechanisms of tongue squamous carcinoma, search for an effective molecular target gene for diagnosing and treating tongue squamous carcinoma, promote early diagnosis, prevention and treatment of the disease and lower the death rate of tongue cancer, firstly, RNA-seq sequencing is utilized to detect differential expression genes of tongue squamous carcinoma, cancer branch and normal oral mucosa; secondly, a Real-time PCR technology is utilized to verify the sequencing result; then, an interference technology is utilized, and expression of the candidate gene KLK14 in tongue squamous carcinoma cells SCC15 is silenced. By means of the novel target gene for diagnosing and treating tongue squamous carcinoma and application thereof, an experimental foundation is laid for clinical application of the KLK14 gene to tongue squamous carcinoma, and a new target gene and theoretical basis are provided for early diagnosis and treatment of tongue squamous carcinoma.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
Biomarkers for oral tongue cancer metastasis and extracapsular spread (ECS)
ActiveUS20070207479A1Reduce protein expressionMicrobiological testing/measurementMaterial analysisLymphatic SpreadMolecular diagnostics
The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological evaluation.
Owner:RGT UNIV OF CALIFORNIA
Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament
Owner:QIDONG GAITIANLI MEDICINES
Radioactive anion resin microsphere and method for preparing same
ActiveCN102671220ALow release rateImprove securityRadioactive preparation carriersRadioactive preparation formsResin microsphereIon exchange
The invention discloses a radioactive anion resin microsphere and a method for preparing the same, and belongs to the technical field of medicines. The radioactive anion resin microsphere is prepared by curing anionic radionuclide in the anion resin of which the diameter is 5 to 200 mu m and the crosslinking degree is 1 to 20 percent in a precipitation mode. The preparation method comprises the following steps of exchanging the anions of radionuclide to the anion resin, making the radionuclide in the anion resin react with a metal cation precipitator in a solution to form a precipitation in the resin, further curing the radionuclide in the resin and preparing the anion resin microsphere of P-32, I-125, I-131, Re-186 or Re-188. The novel radioactive resin microsphere using anion resin microspheres as a carrier has the characteristics of low release rate of radionuclide, high safety, simple preparation process and the like. The radioactive anion resin microsphere can be used for treating malignant tumors such as liver cancer, lung cancer, tongue cancer and the like.
Owner:CHENGDU YUNKE PHARMA
Radioactive particle chain connected by controllable and fast degradable magnesium and magnesium alloy
InactiveCN101804238AImprove mechanical propertiesNo bendingRadiation therapyProstate cancerNasopharyngeal carcinoma
The invention discloses a radioactive particle chain connected by controllable and fast degradable magnesium and a magnesium alloy and belongs to the field of medical devices implanted in bodies. The radioactive particle chain with certain length is prepared by connecting the controllable and fast degradable magnesium, the magnesium alloy 1 and radioactive particles 2 through welding at certain distances. The radioactive particles have the therapeutical effect, and the magnesium and the magnesium alloy are used as connecting materials, so that the radioactive particle chain comprises unique controllable and fast degradation characteristics. The radioactive particle chain has the functions of ensuring uniform distribution of the particles, preventing the particles wandering, and reducing distances among the particles with reduction of tumors and making the particles uniformly distributed on focuses all the time when the particle chain is degraded after being implanted for 1 to 2 months. The radioactive particle chain is suitable for curing extensive diseases such as intracranial tumors, nasopharyngeal carcinoma, oropharyngeal carcinoma, tongue cancer, cervical metastatic tumors, lung cancer, breast cancer, pancreatic cancer, cholangiocarcinoma, liver cancer, prostate cancer, gynecological tumors, and soft tissue and bone tumors.
Owner:张福君 +1
Radioactive particle chain connected by controlled degradable magnesium and magnesium alloy pipe
InactiveCN101987226AImprove mechanical propertiesNo bendingMedical devicesRadioactive preparation carriersLymphatic SpreadProstate cancer
The invention discloses a radioactive particle chain connected by a controlled degradable magnesium and magnesium alloy pipe, which belongs to the field of medical appliance implanted to an organism. The radioactive particles 2 are connected by the controlled degradable magnesium and ultra-thin magnesium alloy pipe 1 at a certain interval. In the invention, the radioactive particle plays a treatment role, and the magnesium and magnesium alloy pipe acts as a connecting material. Due to controllable rapid degradation characteristics, the radioactive particle chain can ensure uniform distribution of particles and prevent particles from wandering. The chain is degradable after being implanted for one week to one month, so that the interval between particles can be reduced with the shrinking of a tumor to uniformly distribute the particles within a lesion. The radioactive particle chain of the invention can be used for treating extensive diseases, which mainly comprise intracranial tumor, nasopharyngeal carcinoma, oropharyngeal cancer, tongue cancer, neck metastases, lung cancer, breast cancer, pancreatic cancer, cholangiocarcinoma, liver cancer, prostate cancer, gynecological tumor, soft tissue and bone tumor.
Owner:张振
Transoral surgical devices and methods
InactiveUS20210228072A1Increase and decrease distanceIncrease the separation distanceTeeth fillingSurgical instrument detailsTonsilPharyngeal Diverticulum
Devices and methods can be used for performing transoral surgery. For example, this document provides oral retractor devices and articulating surgical tools that are well-suited for transoral surgery uses. The devices and methods provided herein may be used to treat conditions such as, but not limited to, mouth cancer, throat cancer, tongue cancer, larynx cancer, tonsil cancer, obstructive sleep disorders, and pharyngeal diverticulum, to provide some examples.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES
Application of Hsp27 in tolerance diagnosis and treatment for tongue cancer chemotherapy
InactiveCN106636296AIncreased chemosensitivityInhibits apoptotic signalingCompound screeningApoptosis detectionTolerabilityChemotherapeutic drugs
The invention discloses an application of Hsp27 in tolerance diagnosis and treatment for tongue cancer chemotherapy. The conditions that the Hsp27 protein level in a tongue cancer cell culture supernatant and the Hsp27 protein level in serum of a tongue cancer patient can be raised through chemotherapeutic drug treatment and expression of the Hsp27 in a tolerance cell for tongue cancer chemotherapy is higher than that in a sensitive cell are verified for the first time; and the chemosensitivity of a drug-resistant cell is improved by interfering with and lowering the expression of the Hsp27 and the chemotherapy tolerance of the tongue cancer cell is improved through overexpression of the Hsp27. New data is provided for research on a tolerance mechanism for tongue cancer chemotherapy, a new detection marker is provided for prediction of the tongue cancer chemosensitivity, and a theoretical basis is provided for development of a new treatment strategy based on the Hsp27 as a target.
Owner:CANCER CENT OF GUANGZHOU MEDICAL UNIV
Topical pathogenic-tissue-destroying liquid
InactiveUS20060057133A1Strong specificityEfficient use ofBiocideInorganic active ingredientsVirus wartsHealthy tissue
The invention relates to a method of producing a pharmaceutical composition, consisting in mixing nitric acid in composition with mucin and ptyalin enzymes which are used as absorbers. Together, said components produce a topical aqueous solution which destroys pathogenic tissue, by coagulating same, in order to treat a patient with warts, verrucas, skin cancer, tongue cancer, throat cancer, ulcerated tonsils, gingivitis, streptococcus or staphylococcus in the throat, uterine cervix cancer or fungus. The inventive composition can also be applied to any part of the skin or mucous membranes. Said composition is administered topically (externally) in one, two, three or four applications depending on the severity of the infection or wound. More specifically, the invention relates to a pharmaceutical composition comprising an effective quantity of nitric acid, mucin and ptyalin and distilled water which is used as an acceptable pharmaceutical vehicle or carrier. The composition is selective given that it strangulates the pathogenic tissue until said tissue is destroyed, leaving the healthy tissue intact apart from a slight mark which is caused by the effects of the nitric acid.
Owner:SUAREZ MENDOZA RAMON
Tongue cancer postoperative defect tongue body reconstruction method and system, readable storage medium and equipment
ActiveCN110246225AReduce failure ratePersonalizedMedical simulation3D modellingFailure rateReconstruction method
The invention provides a tongue cancer postoperative defect tongue body reconstruction method and system, a readable storage medium and equipment, and the reconstruction method comprises the steps: obtaining a tongue body three-dimensional surface grid model through three-dimensional reconstruction; selecting mark points on the surface of the cutting area in the three-dimensional surface grid model of the tongue body, wherein the mark points comprise the lowest point of the cut-off area, the highest point of the cut-off area, two mark points on the front area boundary of the cut-off area, the mark points on the side area boundary of the cut-off area and the mark points on the back area boundary of the cut-off area; on the basis of the selected mark points, fitting a curved surface of the cut-off area; unfolding the curved surface of the excision area to obtain an unfolded surface of the excision area; and measuring the physical parameters of the unfolded surface. According to the invention, the mark points are taken from the reconstructed tongue model, the fitting surface of the resection range of the tongue body is established, and the fitting curved surface is extended into a plane to obtain the area and the contour range of the skin flap to be resected, so that the planning is more consistent with the individualization, and the failure rate of the operation is reduced.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Establishment method for model for promoting tongue cancer development and lymphatic metastasis of mammals
The invention relates to the field of animal models and particularly discloses an establishment method for a model for promoting tongue cancer development and lymphatic metastasis of mammals. According to the establishment method for the model for promoting tongue cancer development and lymphatic metastasis of the mammals, the mammals are fed with a 4-NQO solution and a NaNO2 solution in sequence for a period of time; the mammals are subjected to normal observation every week and killed randomly for HE staining observation and immunohistochemistry CK8 staining observation; when white patches are generated on the tongue faces of the mammals, invasive carcinoma is found through HE staining observation, and lymphatic metastasis is generated through CK8 staining. The establishment method for the animal model for promoting tongue cancer development and lymphatic metastasis with sodium nitrite is established, the progress of the actually-generated tongue cancer is simulated, and a novel and powerful tool is provided for research on the influences of sodium nitrite on the tongue cancer, treatment research on the tongue cancer and the like.
Owner:SUN YAT SEN UNIV
Radioactive anion resin microsphere and preparation method (1) thereof
ActiveCN102671219BLow release rateImprove securityRadioactive preparation carriersRadioactive preparation formsResin microsphereRadiochemistry
Owner:CHENGDU YUNKE PHARMA
Method for preparing and marking bcl-2 (b-cell lymphoma-2) protein of oral squamous cell carcinoma cells through imine acridine fluorescent probe
InactiveCN109354586AThe synthetic route is simpleMild reaction conditionsOrganic chemistryFluorescence/phosphorescenceSquamous CarcinomasFluorescence microscope
Owner:FUJIAN MEDICAL UNIV
Medical application of ursolic acid
InactiveCN1357311ATake advantage ofOpen up new areas of medicinal valueDigestive systemAnhydride/acid/halide active ingredientsDiseaseOral disease
The present invention discloses one new medical application of ursolic acid. Ursolic acid distributed widely in plant has several bioactivities and obvious effect of killing and inhibiting deformed streptococcus, periodontal pathogenic bacteria and oral cavity tongue cancer cell. Therefore, it may be used as effective component in prepairng sanitary article, health product and disease treating medicine for oral cavity. The present invention opens a new way for oral health and oral disease treatment by using the rice plant resource.
Owner:WUHAN UNIV
Traditional Chinese medicine composition for treating tongue cancer and preparation method of traditional Chinese medicine composition
InactiveCN104324269ADefinite curative effectNo side effectsLichen medical ingredientsPill deliveryAsiatic pennywortSide effect
The invention relates to a traditional Chinese medicine composition for treating tongue cancer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following Chinese herb raw materials by weight: 5-10g of berberis thunbergii, 5-10g of asiatic pennywort herb, 3-9g of Indian strawberry root, 5-15g of radix scrophulariae, 5-10g of clausena lansium, 5-10g of kumquat kernel, 3-6g of melastoma dode candrum lour root, 3-8g of lichen of parmelia saxitilis, 5-9g of lalang grass rhizome and 5-10g of Chinese fevervine herb. The traditional Chinese medicine composition can be prepared into pills, capsules and a decoction. The berberis thunbergii, the asiatic pennywort herb, the Indian strawberry root and the radix scrophulariae are capable of clearing internal heat and detoxifying; the clausena lansium and the kumquat kernel are capable of dissipating stasis and stopping pain; the melastoma dode candrum lour root, the lichen of parmelia saxitilis, the lalang grass rhizome and the Chinese fevervine herb are capable of enriching blood and tonifying qi; the various medicinal materials are combined to have an exact curative effect on the tongue cancer without toxic or side effects; the traditional Chinese medicine composition is also effective for oral cancers such as gingiva cancer, oropharyngeal cancer and lip cancer.
Owner:张磊
Preparation method of traditional Chinese medicine preparation for treating tongue cancer
InactiveCN104383358AWith swelling and pain reliefStrong targetingAmphibian material medical ingredientsGranular deliveryMedicinal herbsToad Venom
The invention discloses a preparation method of a traditional Chinese medicine preparation for treating tongue cancer. The traditional Chinese medicine preparation comprises the following raw material medicinal materials: common dysosmatis rhizome and root, wolfberry leaves, plantain herb, Indian aeginetia herb, herb of korsakow monochoria, siam psychotria herb, pilose asiabell root, pinellia tuber, scorpion, stinkweed, Yunnan manyleaf Paris rhizome, Mongolian dandelion herb, coix seeds, rhizoma coptidis, watermelon peel, amur corktree bark, gecko, rhizoma corydalis, toad venom, ivy-like merremia and largehead atractylodes rhizome. The dosage form of the traditional Chinese medicine is capsules. The specific preparation process is as follows: mixing the raw material medicinal materials according to the proportion, drying in an environment at the temperature of 60 DEG C, removing impurities and then placing to cool; grinding the dried materials to particles, then screening by a 60-90mesh sieve, uniformly mixing and then continuously removing the impurities for later use; continuously grinding the particles into powder, screening by a 100-120mesh sieve, then performing ultraviolet disinfection and loading into capsules according to 0.6g / capsule to obtain a finished product. Compared with the prior art, the traditional Chinese medicine preparation has the effects of clearing heat and toxin, cooling and dissipating wind heat, reducing swelling, relieving pain, inducing resuscitation, sterilizing, eliminating maculas and removing a focus and has relatively strong pertinence.
Owner:山东瑞康生命科技有限公司
New indication of paroxetine pharmaceutical composition for treating cancer
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of Paroxetine or a pharmaceutical acceptable salt thereof. The cancer is selected from the group consisting of pleural-related cancer, abdominal-related cancer, endocrine-related cancer, gastrointestinal tract-related cancer, osteosarcoma, skin cancer, and blood cancer. The pleural-related cancer is lung cancer. The abdominal-related cancer is selected from bladder cancer, cervical cancer, and kidney cancer. The endocrine-related cancer is selected from prostate cancer, breast cancer, and ovarian cancer. The gastrointestinal tract-related cancer is selected from gastric cancer, hepatic cancer, colorectal cancer, pancreatic cancer, and tongue cancer.
Owner:LAUNX BIOMEDICAL
Application of doxycycline in preparing antitumor drugs
InactiveCN109568327AEasy to acceptLow priceTetracycline active ingredientsAntineoplastic agentsLymphatic SpreadWilms' tumor
The invention provides application of doxycycline in preparing antitumor drugs, wherein the tumor contains one or a combination of more of tongue cancer, laryngeal cancer, choriocarcinoma, sialaden tumor, gallbladder carcinoma and thymoma. In the application, doxycycline can be used as the drug for inhibiting tumor growth as well as the drug for inhibiting tumor metastasis. The drug can be easilyaccepted by patients, is low-cost, is extensive in source, can be easily acquired and is convenient for understanding the reaction of patients to the drug. Besides, doxycycline will change the existing market structure of tumor chemotherapeutic drugs and can become a clinical drug suitable for long-term administration and capable of effectively inhibiting tumor metastasis, invasion and relapse.
Black garlic extract and application thereof in preventing and curing tongue cancer
InactiveCN105596673AEasy to prepareSuitable for industrial applicationNatural extract food ingredientsAntineoplastic agentsAlcohol ethylOncology
The invention provides a black garlic extract which is prepared by the following steps that black garlic slices are taken, water with the weight of 3-6 times of that of black garlic is added to the black garlic, extraction is performed at the temperature of 85 DEG C to 115 DEG C by 2-4 parts, the mixture is filtered, first filtrate is collected, and filter residue is kept; water with the weight of 1-2 times of that of black garlic is added to the filter residue, composite plant hydrolases with the weight of 0.003-0.05 time of that of black garlic is added to the mixture, enzymolysis is performed, 60%-80% of ethanol solution with the weight of 1-3 times of that of black garlic is added, heating reflux extraction is performed by 3-6 h, filtering is performed to take filtrate, decompress concentration is performed, and second filtrate is obtained after ethyl alcohol removal; the first filtrate and the second filtrate are combined, and the black garlic extract is obtained after mixing. The black garlic extract has an inhibiting effect on growth of the tongue cancer Tc-8113 cell line and can be used for preventing and curing tongue cancer.
Owner:广东益生康生物科技有限公司
Composition having effects of clearing heat and removing toxins
InactiveCN106266612AStomach stagnationHave bad breathMetabolism disorderDigestive systemBaical Skullcap RootChinese licorice
The invention discloses composition having effects of clearing heat and removing toxins. The composition is prepared from raw materials in parts by weight as follows: 15-20 parts of loquat leaves, 15-20 parts of prepared rehmannia roots, 10-15 parts of dried rehmannia roots, 10-15 parts of dwarf lilyturf tubers, 10-15 parts of cochinchinese asparagus roots, 10-17 parts of immature bitter oranges, 8-10 parts of virgate wormwood herbs, 8-13 parts of dendrobium nobile, 10-15 parts of liquorice roots and 10-13 parts of baical skullcap roots. The composition has effects of clearing heat and removing toxins, has functions of removing internal heat of stomach and intestines, activating blood and invigorating the stomach, is used for treating stasis-heat in the stomach, bad breath, sore throat, sores in mouths, oral ulcer, gingival abscess, pharyngolaryngitis, tongue cancer, scurvy, jaundice and the like, has a heat clearing and detoxication function on chronic stomatitis, oral ulcer and perioral cellulitis and has the curative effect commonly superior to that of a conventional anti-bacterial and anti-inflammatory drug.
Owner:GUANGXI HUITOU INTERNET FINANCE SERVICE CO LTD
Method for establishment of tumor lymph node high-metastasis model and rapid fluorescence detection
InactiveCN109010366ASolve the distinctionMammal material medical ingredientsIn-vivo testing preparationsAbnormal tissue growthMetabolite
The invention discloses a method for establishing a model of a large animal tumor lymph node high-metastasis model and rapidly detecting the lymph node containing tumor cells in real time. The methodcomprises the following steps: establishing a rabbit tongue tumor model, and establishing a rabbit cervical lymph node high-metastasis model based on the rabbit tongue tumor model; after successful establishment of the rabbit cervical high-metastasis model, an endogenous substance 5-aminolevulinic acid (5-ALA) is used, and the fluorescence of its metabolite protoporphyrin (PPIX) is used to rapidlyand accurately detect the rabbit cervical lymph node. The method has the advantages of simple operation and high reliability, fully and completely simulates the clinical characteristics and biological characteristics of human tongue cancer lymph node metastasis, provides a research model for the treatment and resection of lymph node metastasis of human tumors, provides a novel means for intraoperative visualization of real-time tumor lymph node dissection, and has broad application prospects in the fields of biomedical and photodynamic diagnosis.
Owner:NANJING UNIV
Pharmaceutical composition for treating tongue cancer and laryngocarcinoma
InactiveCN103989882AImprove the immunityEnhance immune functionHeavy metal active ingredientsHydroxy compound active ingredientsTongue CarcinomaCalculus bovis
The invention discloses a pharmaceutical composition for treating tongue cancer and laryngocarcinoma. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 12-24 parts of cynanchum paniculatum, 12-24 parts of solanum lyratum, 12-24 parts of mock-strawberry, 12-24 parts of sapindus mukorossi gaertn root, 12-24 parts of Chinese actinidia root, 12-24 parts of pseudo-ginseng, 12-24 parts of ginseng, 12-24 parts of astragalus membranaceus, 12-24 parts of desert cistanche, 12-24 parts of nightshade, 12-24 parts of spina gleditsiae, 12-24 parts of indigo naturalis, 12-24 parts of air potato, 9-21parts of calculus bovis factitious, 9-21parts of subprostrate sophora, 9-21parts of calomel, 9-21parts of musk, 9-21parts of borneol, 9-21parts of salviae miltiorrhizae and 9-21parts of talcum powder, the raw materials are combined to active components, the pharmaceutical composition has a good curative effect on tongue cancer and laryngocarcinoma. The invention further discloses use of the pharmaceutical composition.
Owner:李绍华
Application of antitussive and antiasthmatic tablets containing bulbophyllum in preparation of drugs for inhibiting proliferation of human tongue cancer cells TCA 8113
InactiveCN105641446APill deliveryPharmaceutical non-active ingredientsMarsdenia tenacissimaActive ingredient
The invention belongs to the technical field of traditional Chinese medicines and particularly relates to an application of antitussive and antiasthmatic tablets containing bulbophyllum in preparation of drugs for inhibiting proliferation of human tongue cancer cells TCA 8113 as well as a preparation method of the antitussive and antiasthmatic tablets containing bulbophyllum. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared from raw material medicines including 200 g of bulbophyllum, 200 g of Chinese fevervine herbs, 100 g of leatherleaf mahonia stems, 100 g of marsdenia tenacissima, 100 g of common bletilla pseudobulb, 100 g of giant knotweed rhizomes, 100 g of garden balsam stems and 100 g of manyflower solomonseal rhizomes. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared through supercritical extraction, so that the content of rheum emodin is greatly increased.
Owner:JINAN XINSHIDAI MEDICINE SCI & TECH
Method for researching antineoplastic effect of apatinib based on PDX model
PendingCN114028586AObserve the inhibitory effectCompounds screening/testingOrganic active ingredientsPharmaceutical drugOncology
Owner:南昌大学附属口腔医院
Application of secretory protein 1 rich in cysteine in medical apparatus
Owner:苏州市马尔泰新材料有限公司
Biomarkers for oral tongue cancer metastasis and extracapsular spread (ECS)
ActiveUS7588895B2Microbiological testing/measurementMaterial analysisLymphatic SpreadBiomarker (petroleum)
Owner:RGT UNIV OF CALIFORNIA
Application of bostrycin
InactiveCN111329848AGrowth inhibitionPrevent proliferationOrganic active ingredientsAntineoplastic agentsCancer cellApoptosis pathways
Owner:WUHAN POLYTECHNIC UNIVERSITY
Radioactive anion resin microsphere and method for preparing same
ActiveCN102671220BLow release rateImprove securityRadioactive preparation carriersRadioactive preparation formsResin microsphereIon exchange
Owner:CHENGDU YUNKE PHARMA
A new target gene for diagnosis and treatment of tongue squamous cell carcinoma and its application
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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