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Medical application of ursolic acid

A technology of ursolic acid and supplies, applied in pharmaceutical formulations, anhydride/acid/halide active ingredients, digestive system, etc., can solve problems such as no inhibition of oral tongue squamous cell carcinoma cells

Inactive Publication Date: 2002-07-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ursolic acid is widely distributed in a variety of plants and has a variety of biological activities. However, according to the Medline search of the National Library of America, there is no report that ursolic acid can inhibit various types of Streptococcus mutans and periodontal pathogens in the oral cavity.
At the same time, there is no report of inhibition of oral tongue squamous cell carcinoma cell lines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Effect of ursolic acid on streptococcus mutans and periodontal pathogenic bacteria

[0029] (1) Materials and methods

[0030] 1) strain

[0031] Forsythus Bacteroides (B.forsythus Bf) ATCC43037

[0032] Porphyrobacter gingivalis (P.gingivalis pg) ATCC33277

[0033] Intermedia Prevotella (P.intermedia Pi) ATCC25611

[0034] Streptococcus hamster AHT serotype a

[0035] Streptococcus murine BHT serotype b

[0036] Streptococcus mutans MT8148 serotype c

[0037] Streptococcus mutans OMZ65 serotype g

[0038] Streptococcus mutans OMZ175 serotype f

[0039] Streptococcus mutans OMZ176 serotype d

[0040] Streptococcus mutans G8-5M0 serotype e

[0041] Streptococcus villosa 6715 serotype g

[0042] Streptococcus dowlerii Mfe28 serotype h

[0043] Streptococcus Gordonii

[0044] 2. Reagents and instruments Haenatin hydrochloride Vitamin K1 injection, Shanghai Institute of Biology, Chinese Academy of Sciences, Jiangsu Siyang Pharmaceutical Factory

[0045] 96-well...

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Abstract

The present invention discloses one new medical application of ursolic acid. Ursolic acid distributed widely in plant has several bioactivities and obvious effect of killing and inhibiting deformed streptococcus, periodontal pathogenic bacteria and oral cavity tongue cancer cell. Therefore, it may be used as effective component in prepairng sanitary article, health product and disease treating medicine for oral cavity. The present invention opens a new way for oral health and oral disease treatment by using the rice plant resource.

Description

1. Technical field [0001] The invention relates to a new application of ursolic acid, specifically, the ursolic acid is used as an active ingredient in the preparation of oral hygiene products, oral health products and medicines for treating oral diseases. 2. Background technology [0002] Ursolic acid is a triterpenoid compound with the molecular formula C 30 h 18 o 3 , the chemical name is 3β-hydroxy-arbutane-12-ene-28-carboxylic acid, it is a colorless crystal with a melting point of 289-292°C. Ursolic acid is widely distributed in a variety of plants and has a variety of biological activities. However, according to the Medline search of the National Library of America, there is no report that ursolic acid can inhibit various types of Streptococcus mutans and periodontal pathogens in the oral cavity. At the same time, there is no report of inhibition of oral tongue squamous cell carcinoma cell lines. [0003] Oral caries and periodontal disease are common and frequent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P1/02
Inventor 樊明文边专王茜
Owner WUHAN UNIV
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