49results about How to "Large population" patented technology

A method of analyzing electrocardiogram (EKG) data for use in the diagnosis of heart disease, prognosis of cardiac conditions, and the monitoring of heart disease therapies is disclosed. The method utilizes a wavelet-based multifractal analysis with one or more of (1) a discrete wavelet smoothing step to remove the effects of abnormal beats; (2) “Levy flight” analysis to detect the frequency of abnormal beats known to adversely affect the multifractal (MF) analysis; and (3) MF alpha analysis, a multifractal extension of monofractal short term (ST) alpha analysis. The invention further comprises an EKG test battery comprising Levy flight anomalous beat / beat cluster screening, followed by (ST) MF alpha analysis and MF Holder analysis (when validated by the Levy flight analysis). The wavelet smoothing step can also be used to classify human EKGs by observing the effect of sequential smoothing on the MF Holder coefficient. Alternative choices to the wavelet smoothing approach to removal of abnormal beat effects include probability distribution function analysis to determine the MF Holder coefficient directly, abnormal beat ridge skeleton removal to remove the offending beats based on a direct multifractal spectrum calculation, and the calculation of various types of entropy coefficients for the EKG time series.

The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.

A multi-sensor mobile phone, which is widely applicable in the fields, such as environmental monitoring, medical services, public security, disaster rescue and the like, comprises an antenna (1), a display screen (2), a sensor mobile phone keyboard (7), a receiver (4) and a microphone (5), wherein, the sensor in the sensor mobile phone keyboard (7) can be a body temperature sensor, a spectrometric sensor, a fingerprint sensor, a humidity sensor, a gas composition monitoring sensor, an audio / video sensor, a pulse sensor, a blood oxygen sensor or other sensors which can be integrated into the mobile phone keyboard and are ultrathin; during the procedures for collecting sensor data and pre-processing the collected data in the mobile phone, the procedure for processing data is performed by the following parts together: local command, downlink command, a sensing and collecting control module, the sensor mobile phone keyboard, a micro-processor, a data forwarding module, uplink, the display screen and voice; and meanwhile, the multi-sensor serves the function of establishing a local area network.

Disclosed is a stentless transluminally implantable heart valve, having a formed in place support. The formed in place support exhibits superior crush resistance when compared to conventional balloon expandable or self expandable stent based valves.

Devices for the non-invasive collection of a liquid sample in small quantities, such as urine for testing hydration in infants and incontinent adults, directly at the source of that sample, isolation of the collected sample from a testing site, the transportation of that sample to a site for testing contained within the device itself, and the selective application of some or all of the specimen to a testing apparatus contained within the device itself, with a minimum of specimen handling required. Other aspects include a method and device for facilitating the reading of the result of the specimen test by a skilled or unskilled user, including means for determining that no adequate sample has been delivered to the testing site.

A system and method for wireless communication between a plurality of subscriber units and a base station, the base station communicating information signals from an originating source to a destination subscriber unit over a channel at an assigned one of a plurality of frequencies using repetitive time frames, each said time frame comprising a sequence of time slots. The channel is defined as having the same one or more time slots from the sequence of time slots in one or more of the time frames. The base station includes a central processing unit capable of assigning a duration of time for the information signals being sent to the destination subscriber unit. The duration equals the duration of one or more time slots in the same frame. The central processing unit maintains a memory of which time slots of each time frame have been assigned and provides the time slot assignment, and therefore channel assignment, by consulting said memory. The system includes a multiplexer for multiplexing the information signals onto the assigned channel; and a transmitter for transmitting the information signals to the destination subscriber unit using the assigned channel.

Disclosed is a stentless transluminally implantable heart valve, having a formed in place support. The formed in place support exhibits superior crush resistance when compared to conventional balloon expandable or self expandable stent based valves.

Mattresses and methods for processing a flexible foam material for use in a mattress to provide a mattress foam material that has more consistent firmness over time and area. The methods include pre-conditioning the foam pad or mattress by applying a force across a substantial portion of a major surface of the mattress to compress or stretch the height of the foam, the length of the foam, and / or the width of the foam to break or open closed cells. In certain embodiments, the force is applied by repeatedly pressing a platen against the foam pad or placing the foam pad between one or more rollers.

Described herein are apparatuses (e.g., systems, devices) and methods for processing, distributing, and analyzing medical data. In particular, apparatuses and methods for processing and distributing tasks or jobs for completion by a qualified worker or specialist are described. Crowdsourcing data to specialists for interpretation can be accomplished using an auction system to match the specialists with discrete portions of the data. The data can be bundled based on one or more categories or characteristics, and then placed on an auction where the specialists can bid for each bundle by submitting a payment price. The data can be medical data, such as ECG data, imaging data and test data.

The present invention provides for a method for stimulating the proliferation of pluripotential stem cells in a mammal comprising administration of pregnancy related compounds more particularly human chorionic gonadotropin, leutenizing hormone or prolactin. The present invention further provides for a method of treatment of tissues or organs experiencing cellular damage, injury or disease.

Methods for the non-invasive collection of a liquid sample in small quantities, such as urine for testing hydration in infants and incontinent adults, directly at the source of that sample, isolation of the collected sample from a testing site, the transportation of that sample to a site for testing contained within the device itself, and the selective application of some or all of the specimen to a testing apparatus contained within the device itself, with a minimum of specimen handling required. Other aspects include a method and device for facilitating the reading of the result of the specimen test by a skilled or unskilled user, including means for determining that no adequate sample has been delivered to the testing site.

The present invention is long-term cultures of avian PGCs and techniques to produce germline chimeric and transgenic birds derived from prolonged PGC cultures. In some embodiments, these PGCs can be transfected with genetic constructs to modify the DNA of the PGC, specifically to introduce a transgene encoding an exogenous protein. When combined with a host avian embryo by known procedures, those modified PGCs produce germline chimeric birds. These germline chimeric birds do not have PGC derived somatic cells or tissues. This invention includes compositions comprising long-term cultures of PGCs that can be genetically modified by gene targeting, that can accept large amounts of foreign DNA and that contribute to the germline of recipient embryos.

A database system and method combines the ability to concurrently utilize LDAP based authentication and operating system-based authentication. The database authentication tries both methods of authentication, both at the database layer and at the application layer. Security authentication of the user then occurs by whichever mechanism is first to return a successful result. Database administrators can, if desired, configure the system to prefer one mechanism (LDAP or operating system) over the other. With the present invention, a large end user population can be managed using standard LDAP tools, in an automated, administered, or “self-service” manner, as preferred. Thus, system accounts, such as the database owner, can remain within the operating system, easing installation and maintenance of the database product itself.

Described herein are apparatuses (e.g., systems, devices) and methods for processing, distributing, and analyzing medical data. In particular, apparatuses and methods for processing and distributing tasks or jobs for completion by a qualified worker or specialist are described. Crowdsourcing data to specialists for interpretation can be accomplished using an auction system to match the specialists with discrete portions of the data. The data can be bundled based on one or more categories or characteristics, and then placed on an auction where the specialists can bid for each bundle by submitting a payment price. The data can be medical data, such as ECG data, imaging data and test data.

The present invention is long-term cultures of avian PGCs and techniques to produce germline chimeric and transgenic birds derived from prolonged PGC cultures. In some embodiments, these PGCs can be transfected with genetic constructs to modify the DNA of the PGC, specifically to introduce a transgene encoding an exogenous protein. When combined with a host avian embryo by known procedures, those modified PGCs are transmitted through the germline to yield transgenic offspring. These germline chimeric birds do not have substantial contributions of PGC-derived phenotypes in somatic cells or tissues. This invention includes compositions comprising long-term cultures of PGCs that can be genetically modified by gene targeting, that can accept large amounts of foreign DNA and that contribute to the germline of recipient embryos.

A computer-implemented method and computer system for analyzing a wireless data market. Embodiments provide convenient and effective mechanisms for collecting, processing and classifying wireless data information, which may then be output to provide market analysis for wireless data markets. The wireless data information may be obtained from online bills of a panel of wireless subscribers, thereby reducing subscriber interaction and enabling more complete and frequent access to the wireless data information. Once the wireless data information is obtained, it may be standardized, cleaned and / or appended with additional information to provide further and / or more relevant market analysis. The data may be classified in one or more passes to further refine the market analysis, where classification may be by a data type, by another characteristic of the data, etc.

An annular ion guide is disclosed comprising inner and outer electrodes. Ions are confined within an annular ion guiding region by RF or pseudo-potential barriers in both an outward and inward radial direction.

This invention relates to methods for transforming cotton using isolated shoot apical tips of seedlings. The apical shoot tips of cotton seedlings are isolated and chilled at a low temperature to slow the metabolic activity of the isolated cells, and then inoculated with a transforming agent carrying a desired gene. The invention also provides a method of regenerating transformed cotton plants with a desired trait from transformed apical shoot tips.

A device that helps clear a fluid or other material lodged in a person's throat has a barrel with an open proximal end and an opening laden distal end. A plunger is slidably disposed within the barrel such that the plunger, by being manually drawn outwardly, creates suction within the barrel drawing air through the opening. A single or multi-section tube, flexible on at least its distal end, is fluid flow connected to the opening and has a face mask along its length. The distal end of the tube is intubated with a person proximate the fluid or other material so that as the plunger is drawn outwardly through the barrel, the suction created within the barrel causes air to be drawing in through the tube and into the barrel thereby helping draw out and dislodge the fluid or other material. A backflow valve located on the barrel helps clear the barrel of such things as vomit that might have been drawn into the barrel.

An interlocking nail having an hour-glass geometry is used for repair of bone fractures. The hour-glass interlocking nail includes a proximal section, a mid section, and a distal section. Each section of the hour-glass interlocking nail has a diameter. The proximal and distal sections each have a diameter larger than the mid section so that the interlocking nail has an hour-glass geometry. The hour-glass interlocking nail comprises at least one fixation aperture located within either the proximal or distal section of the hour-glass interlocking nail. Preferably, the fixation aperture has a tapered locking design adapted to receive a screw-cone peg. The hour-glass geometry utilized by the interlocking nail is better suited to address a larger population of bone canal geometries, stressing the fracture site with known values within the healing process and preventing inadvertent perforation of the nail through the cortex of the bone. Hour-glass nail geometry more appropriately distributes stresses and promotes better healing at the bone fracture.

This invention relates to an effective dietary intervention plan. In one aspect all food is withheld for a period of at least 5 days, except for tropical root crops. In another aspect the invention relates to the treatment of various symptoms, conditions or diseases such as Diarrhea, constipation, congestion, eczema, asthma, fatigue, muscle weakness, tension, and spasms, irritable bowel syndrome, swelling, anxiety, multiple chemical sensitivities, moderate to extensive and moderate to severe symptoms due to food allergies, sensitivities, and intolerances, bloating, pain, headaches, leaky gut, hyperactivity, sleeping difficulties, severe underweight, eating disorders, obsessive, compulsive disorders, panic attacks, sensory sensitivities, Alzheimer's disease, acid reflux, irritability, delayed motor skills, delayed social skills, autism, PDD, infantile spasms, seizures by withholding from the patient for a period of at least 5 days all food except for concentrated forms of concentrated tropical root crops. Preferably the patient is also removed from external environmental sources of allergens. After the initial withholding period new foods may be introduced according to a particular selection and schedule.

Consumer electronic (CE) devices can each store a concierge network address of a centralized information server (CIS). In response to receiving a model number from a CE device, the CIS can return a list of resources available to the CE device, including network addresses for an update list server providing the CE device with a list of current software available for download to the CE device, a news link server providing the CE device with a list of news feeds, and a video / music list server providing a list of video and / or music available to the CE device.

A method of fabricating a thin film device having conductive front and backside electrodes or contacts. Top-side cavities are first formed on a first dielectric layer, followed by the deposition of a metal layer on the first dielectric layer to fill the cavities. Defined metal structures are etched from the metal layer to include the cavity-filled metal, followed by depositing a second dielectric layer over the metal structures. Additional levels of defined metal structures may be formed in a similar manner with vias connecting metal structures between levels. After a final dielectric layer is deposited, a top surface of a metal structure of an uppermost metal layer is exposed through the final dielectric layer to form a front-side electrode, and a bottom surface of a cavity-filled portion of a metal structure of a lowermost metal layer is also exposed through the first dielectric layer to form a back-side electrode.

The present description relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of cancer. The present description further relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Mattresses and methods for processing a flexible foam material for use in a mattress to provide a mattress foam material that has more consistent firmness over time and area. The methods include pre-conditioning the foam pad or mattress by applying a force across a substantial portion of a major surface of the mattress to compress or stretch the height of the foam, the length of the foam, and / or the width of the foam to break or open closed cells. In certain embodiments, the force is applied by repeatedly pressing a platen against the foam pad or placing the foam pad between one or more rollers.

Human and animal serum contains naturally occurring autoantibodies that develop at birth in absence of deliberate immunization. These antibodies are predominantly of IgM isotype but can include all immunoglobulin isotypes such as IgD, IgA and IgG. Here we describe IgM anti-lymphocyte autoantibodies (IgM-ALA) and show that these antibodies are heterogenous with some antibodies binding to chemokine receptors such as CCR5 and CXCR4 and others binding to other lymphocyte receptors including CD3, CD2, CD4 and CD81. These IgM-ALA, unlike IgG antibodies, are not cytolytic to cells at 37 C and hence function to alter lymphocyte function including cytokine production and act as “blocking antibodies to inhibit binding of chemokines and viruses including HIV-1 and Hepatitis C. IgM antibodies that bind to receptors on lymphocyte also bind to the same or similar class of receptors on other leucocytes and other cells such as cancer cells and endothelial cells. The inventor claims that naturally occurring anti-lymphocyte antibodies inhibit viral infections, cancer and several inflammatory states by binding to chemokine receptors and other cell membrane receptors that activate cells or promote viral entry and replication. Inventor also claims methods for quantitating levels of IgM-ALA with different receptor specificities to aid in preventing disease progression and also claims methods to enhance in-vivo or in-vitro production of IgM-ALA.

An interlocking nail having an hour-glass geometry is used for repair of bone fractures. The hour-glass interlocking nail includes a proximal section, a mid section, and a distal section. Each section of the hour-glass interlocking nail has a diameter. The proximal and distal sections each have a diameter larger than the mid section so that the interlocking nail has an hour-glass geometry. The hour-glass interlocking nail comprises at least one fixation aperture located within either the proximal or distal section of the hour-glass interlocking nail. Preferably, the fixation aperture has a tapered locking design adapted to receive a screw-cone peg. The hour-glass geometry utilized by the interlocking nail is better suited to address a larger population of bone canal geometries, stressing the fracture site with known values within the healing process and preventing inadvertent perforation of the nail through the cortex of the bone. Hour-glass nail geometry more appropriately distributes stresses and promotes better healing at the bone fracture.

Methods and materials for the cryopreservation of cellularised scaffolds used for therapeutic or pharmacological testing purposes that provide a cultured scaffold on which cells have been seeded, equilibrate the cellularised scaffold with a cryopreservative composition comprising culture medium and between 5 and 30% of a cryoprotectant such as DMSO, freeze the equilibrated cellularised scaffold by reducing the temperature continuously by about −1° C. / minute to about −80° C., and store the frozen cellularised scaffold at a temperature of between −135° C. and −198° C.