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Radioactive particle chain connected by controlled degradable magnesium and magnesium alloy pipe

A radioactive particle, rapid degradation technology, applied in radioactive carrier, radioactive physical shape, radiotherapy, etc., can solve the overall curative effect of brachytherapy that affects clinical radioactive particles, uneven particle dose distribution, and difficulty in maintaining the straight line spacing of particles, etc. problems, to achieve uniform distribution, excellent mechanical properties, and good compatibility.

Inactive Publication Date: 2011-03-23
张振
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, in the actual operation of particle implantation, it is often difficult to maintain the linear arrangement of particles and the distance between particles, which makes the particle dose distribution uneven and affects the overall curative effect of clinical radioactive particle brachytherapy.

Method used

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  • Radioactive particle chain connected by controlled degradable magnesium and magnesium alloy pipe
  • Radioactive particle chain connected by controlled degradable magnesium and magnesium alloy pipe
  • Radioactive particle chain connected by controlled degradable magnesium and magnesium alloy pipe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] as attached figure 1 As shown, a certain length of magnesium or magnesium alloy ultra-thin tube ( figure 1 -①) and 6711-type iodine-125 particles with a diameter of 0.8mm and a length of 4.5mm ( figure 1 -②) Wash and dry. Use a metal thimble to place 6711-type iodine-125 particles one by one into a magnesium or magnesium alloy ultra-thin tube at a distance of 10 mm to make a radioactive particle chain of a certain length. The length of the particle chain depends on the number of particles. Particle chains of a certain length can be made in batches in advance, and intercepted according to needs before surgery, or particle chains of various lengths can be made according to the treatment plan. During the operation, the prepared particle chains are loaded into a matching implant gun, and implanted into the tumor body under the guidance of medical imaging equipment according to the preoperative plan (TPS).

Embodiment 2

[0031] as attached figure 2 As shown, the magnesium or magnesium alloy ultra-thin tubes drawn through multiple passes are cut into 10mm short tubes ( figure 1 -①) Combine it with 6711-type iodine-125 particles with a diameter of 0.8mm and a length of 4.5mm ( figure 1 -②) Wash and dry. Use magnesium or magnesium alloy ultra-thin short tubes to connect 6711-type iodine-125 particles end to end, and the distance between two adjacent particles is 5mm to make a radioactive particle chain of a certain length. The length of the particle chain depends on the number of magnesium or magnesium alloy ultra-thin short tubes and radioactive particles. Particle chains of a certain length can be made in batches in advance, and intercepted according to needs before surgery, or particles of various lengths can be made according to the treatment plan. chain. During the operation, the prepared particle chains are loaded into a matching implant gun, and implanted into the tumor body under the ...

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Abstract

The invention discloses a radioactive particle chain connected by a controlled degradable magnesium and magnesium alloy pipe, which belongs to the field of medical appliance implanted to an organism. The radioactive particles 2 are connected by the controlled degradable magnesium and ultra-thin magnesium alloy pipe 1 at a certain interval. In the invention, the radioactive particle plays a treatment role, and the magnesium and magnesium alloy pipe acts as a connecting material. Due to controllable rapid degradation characteristics, the radioactive particle chain can ensure uniform distribution of particles and prevent particles from wandering. The chain is degradable after being implanted for one week to one month, so that the interval between particles can be reduced with the shrinking of a tumor to uniformly distribute the particles within a lesion. The radioactive particle chain of the invention can be used for treating extensive diseases, which mainly comprise intracranial tumor, nasopharyngeal carcinoma, oropharyngeal cancer, tongue cancer, neck metastases, lung cancer, breast cancer, pancreatic cancer, cholangiocarcinoma, liver cancer, prostate cancer, gynecological tumor, soft tissue and bone tumor.

Description

technical field [0001] The invention belongs to the field of medical equipment implanted in a body, and in particular relates to a controllable and rapidly degradable magnesium and a radioactive particle chain connected by a magnesium alloy tube. Background technique [0002] Interstitial implantation of radioactive seeds for treating malignant tumors is a design scheme using computerized stereotaxic planning system (TPS). Under the guidance of modern medical imaging, radioactive particles are implanted into the tumor or infiltrated by the tumor in a minimally invasive way according to the size and shape of the tumor. In the invaded tissue, the continuous and short-distance radiation is emitted by the micro-radiation source, so that the tumor tissue is killed to the greatest extent, while the normal tissue is not damaged or only slightly damaged, and finally achieves the purpose of treating the tumor. Because particle implantation therapy has the characteristics of less trau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M36/02A61M31/00A61K51/12A61K51/02
Inventor 张振
Owner 张振
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