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New indication of paroxetine pharmaceutical composition for treating cancer

a technology of paroxetine and composition, which is applied in the direction of drug composition, peptide/protein ingredients, cardiovascular disorders, etc., can solve the problems of poor drug response in patients, the treatment method of cancer has become an important issue, and the manufacturing of drugs is also a big problem

Inactive Publication Date: 2017-10-26
LAUNX BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides new cancer indications for a drug called Paroxetine. The experiments showed that Paroxetine had no toxicity or little toxicity to normal cells. The invention also provides a pharmaceutical composition of Paroxetine for treating cancer. The cancer can be selected from various types including lung cancer, bladder cancer, cervical cancer, kidney cancer, prostate cancer, breast cancer, and tongue cancer, among others. The effective dose of Paroxetine can range from 20 mg / kg / day to 500 mg / kg / day. This information can help researchers and medical professionals better understand and treat cancer using Paroxetine.

Problems solved by technology

The cancer patients are gradually increase yearly, therefore the treatment method of the cancer has become an important issue.
Otherwise, the manufacturing of the drug is also a big problem.
When the drug starting the clinical trials, there are lots of problems need to overcome, such as drug safety, patient selection, trial dose and other issues.
Even the drug has approved by the FDA and sales on the market, there still possibly face the situation of the poor drug response in patients.
Furthermore, if the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure.
Therefore, the new drug development is very difficult.

Method used

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  • New indication of paroxetine pharmaceutical composition for treating cancer
  • New indication of paroxetine pharmaceutical composition for treating cancer
  • New indication of paroxetine pharmaceutical composition for treating cancer

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0021]Cell Culture

[0022]Subculture the different types of cancer cells. The cancer cells includes lung cancer, gastric cancer, hepatic cancer, colon cancer, skin cancer, cervical cancer, prostate cancer, bladder cancer, breast cancer, leukemia, pancreatic cancer, ovarian cancer, tongue cancer, osteosarcoma, and renal cancer. The normal cells used in the control group included kidney cells (HEK293), canine fibroblast cell line HFW, and human bronchial epithelial cell line BEAS-2B. (as shown in Table 1).

[0023]Cancer cell lines were cultured in different culture medium according to different characteristics (as shown in Table 1). The cell numbers were counted and reseed as 2×106 in culture plate / flask. Then, the culture medium were added to a volume of 10 ml, and the cells were cultured for 2-3 days. Then, the cells were suspended for loading into 96-well plates. The number of cells was 3000 and the volume of the culture medium was 100 μl each well.

TABLE 1Cancer cell lines and culture ...

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Abstract

A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of Paroxetine or a pharmaceutical acceptable salt thereof. The cancer is selected from the group consisting of pleural-related cancer, abdominal-related cancer, endocrine-related cancer, gastrointestinal tract-related cancer, osteosarcoma, skin cancer, and blood cancer. The pleural-related cancer is lung cancer. The abdominal-related cancer is selected from bladder cancer, cervical cancer, and kidney cancer. The endocrine-related cancer is selected from prostate cancer, breast cancer, and ovarian cancer. The gastrointestinal tract-related cancer is selected from gastric cancer, hepatic cancer, colorectal cancer, pancreatic cancer, and tongue cancer.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is a National Phase Application filed under 35 U.S.C. 371 as a national stage of PCT / CN2015 / 092780 filed Oct. 23, 2015, an application claiming the benefit under 35 USC 119(e) to the following U.S. Provisional Applications No. 62 / 068,298 filed Oct. 24, 2014, the content of each of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention related to a new indication of Paroxetine pharmaceutical composition, especially related to inhibition effect of Paroxetine pharmaceutical composition on a variety of cancer cells.BACKGROUND OF THE INVENTION[0003]Cancer is the most popular disease cause of death in the world. The cancer patients are gradually increase yearly, therefore the treatment method of the cancer has become an important issue. The medical treatments of cancer can be classified as surgical treatment, radiation therapy, chemotherapy and target therapy. Generally, the cancer drug,...

Claims

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Application Information

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IPC IPC(8): A61K31/4525A61K31/085
CPCA61K31/085A61K31/4525A61K31/4427A61K31/137A61K31/00A61K38/00A61K38/02A61K38/14A61K31/138A61K31/196A61K31/197A61K31/216A61K31/341A61K31/366A61K31/404A61K31/505A61K31/549A61K31/55A61K31/7056A61K38/05A61K31/381A61P31/00A61P31/10A61P35/00A61P35/02A61P35/04A61P9/00A61K31/397A61K31/4422A61K2300/00C07C211/27C07C211/30A61K45/06
Inventor CHEN, CHIU-HUNGCHUANG, SHOW-MEIWAY, TZONG-DERHSIAO, NAI-WAN
Owner LAUNX BIOMEDICAL
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