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Radioactive anion resin microsphere and preparation method (1) thereof

An anion resin and weakly basic anion technology, applied in the direction of radioactive carriers, radioactive physical shapes, etc., can solve the problems of relying on reactors, high density of glass microspheres, and high purity requirements of raw materials

Active Publication Date: 2013-12-11
CHENGDU YUNKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of radioactive glass microspheres is limited due to the disadvantages of high density of glass microspheres, high purity requirements of raw materials, complex preparation process and dependence on reactors.
The resin microspheres have the advantages of low density and simple preparation process, but the microspheres prepared by the existing method have a high release rate of radionuclides, so a new preparation process is required to reduce the release rate of the radioactive resin microspheres.

Method used

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  • Radioactive anion resin microsphere and preparation method (1) thereof
  • Radioactive anion resin microsphere and preparation method (1) thereof
  • Radioactive anion resin microsphere and preparation method (1) thereof

Examples

Experimental program
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Effect test

Embodiment 1-2

[0053] Embodiment 1-2: Sr-89 anion resin microspheres.

[0054] The anionic resin microspheres listed in embodiment 1 and embodiment 2 include the styrene-divinylbenzene anion exchange resin (201 × 7 resin) with a cross-linking degree of 7% and a diameter of 20 μm to 40 μm, and are solidified in the form of precipitation on The Sr-89 anion resin microsphere inside the 201×7 resin anion resin.

Embodiment 1

[0056] (1) 1g of styrene-divinylbenzene anion exchange resin (201×7 resin) with a cross-linking degree of 7% and a diameter of 20 μm to 40 μm is transformed into an OH-type strong alkalinity;

[0057] (2) Place the anion resin obtained in step (1) under room temperature conditions in 20mL, and the mass percent concentration that the pH value is 11 is 3% Na 3 PO 4 Soaked in the solution for 30min, the PO 4 3- Exchange to the inside of the anion resin obtained in step (1); wash with water until the pH value of the cleaning solution is less than 8;

[0058] (3) The adsorbed PO obtained in step (2) 4 3- The resin was added to 20 mL of pH 5 containing 3.3 GBqSr-89 89 SrCl 2 In the solution, react at room temperature for 4 hours, make the cationic radionuclide in the solution react with the anion exchanged into the resin to form a precipitate, and then wash the precipitated resin with Sr-89 with distilled water until the pH value of the washing solution is 6, to obtain 89 Sr ...

Embodiment 2

[0060] At room temperature, put 1 g of OH-type strongly basic styrene-divinylbenzene anion exchange resin (201×7 resin) with a crosslinking degree of 7% and a diameter of 20 μm to 40 μm in a mass of 20 mL with a pH value of 11 The percentage concentration is 4% Na 2 WO 4 Soaked in the solution for 50min, the WO 4 2- Exchange to the inside of the anion resin; wash with water until the pH value of the cleaning solution is less than 8;

[0061] will be adsorbed with WO 4 2- The anion resin was added to 20mL, pH value of 5 containing 3.3GBq Sr-89 89 SrCl 2 In the solution, react at room temperature for 4 hours, make the cationic radionuclide in the solution react with the anion exchanged into the resin to form a precipitate, and then wash the precipitated resin with Sr-89 with distilled water until the pH value of the washing solution is 6, to obtain 89 Sr anion resin microspheres 2.

[0062] Soak the prepared Sr-89 anion resin microspheres 1 and 2 in normal saline and hum...

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Abstract

The invention discloses a radioactive anion resin microsphere and a preparation method (1) thereof and belongs to the technical field of medicines. The radioactive anion resin microsphere is formed by solidifying cation radionuclide in anion resin with the diameter of 5 mu m-200mu m and crosslinking degree of 1%-2% in a sediment mode. The preparation method of the radioactive anion resin microsphere comprises exchanging a non-radioactive anion precipitant into the anion resin, adding the obtained anion resin into solution containing cation radionuclide, enabling the cation radionuclide in the solution to react with the anion precipitant adsorbed in the resin to form sediments, enabling the radionuclide to be solidified in the resin, and preparing the radioactive anion resin microsphere. The radioactive anion resin microsphere has the advantages of being low in radionuclide release rate, high in safety and simple in preparation process and the like. The radioactive anion resin microsphere can be used for curing malignant tumors such as liver cancer, lung cancer and tongue cancer.

Description

technical field [0001] The invention discloses a radioactive resin microsphere and a preparation method thereof, in particular to an anionic resin microsphere containing radionuclide Y-90, Sr-89 or Lu-177 and a preparation method thereof. The radioactive anion resin microspheres of the present invention are mainly used for internal radiation interventional therapy of malignant tumors such as liver cancer, lung cancer and tongue cancer. Background technique [0002] Malignant tumors are the number one killer of human health, such as liver cancer, which not only has a high incidence rate, but also is dangerous and difficult to treat, with a high mortality rate. Malignant tumors are difficult to achieve the desired effect by a single treatment method, and often require multidisciplinary comprehensive treatment, such as surgery, chemotherapy, radiotherapy and other means. Among them, radiotherapy mainly uses radiation and ionizing radiation emitted by radionuclides to inhibit a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/06A61K103/00A61K103/32
Inventor 邓启民尹帮顺程作用李明起李茂良潘俊男王翰
Owner CHENGDU YUNKE PHARMA
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