Radioactive anion resin microsphere and method for preparing same

An anion resin, anion technology, applied in the directions of radioactive carrier, radioactive physical shape, drug combination, etc., can solve the problems of high purity requirements of raw materials, complex preparation process, dependence on reactors, etc.

Active Publication Date: 2013-12-11
CHENGDU YUNKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of radioactive glass microspheres is limited due to the disadvantages of high density of glass microspheres, high purity requirements of raw materials, complex preparation process and dependence on reactors.
The resin microspheres have the advantages of low density and simple preparation process, but the release rate of the microspheres prepared by the existing method is high, so a new preparation process is needed to reduce the radionuclide release rate of the radioactive resin microspheres

Method used

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  • Radioactive anion resin microsphere and method for preparing same
  • Radioactive anion resin microsphere and method for preparing same
  • Radioactive anion resin microsphere and method for preparing same

Examples

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Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: 32 P anion resin microspheres

[0063] (1) the styrene-divinylbenzene anion-exchange resin (201 × 7 resin) that 2g crosslinking degree is 4%, and diameter is 10 μm~100 μm is transformed into OH type strongly basic anion resin;

[0064] (2) under room temperature conditions, the strong basic anion resin obtained in step (1) contains 8GBq in 20mL, pH value is 10 32 Na of P 3 PO 4 React in the solution for 1 hour, and exchange the radionuclide anion to the inside of the anion resin;

[0065] Get the reaction solution and use BH1216 type low background α, β measuring instrument (produced by Beijing Nuclear Instrument Factory) to measure remaining in the solution 32 P activity, calculated 32 P utilization rate, and then wash the resin with water until the pH value of the cleaning solution is less than 8;

[0066] (3) Exchange 1g of them with 32 The resin of P was added to 20 mL of YCl containing 200 μg Y at pH 5 3 solution, react at room temperature for 4h...

Embodiment 2

[0072] Embodiment 2: I-131 anionic resin microspheres

[0073] Put 2g of OH-type strongly basic styrene-divinylbenzene anion exchange resin (201×7 resin) with a cross-linking degree of 4% and a diameter of 10 μm to 100 μm at room temperature in 20 mL of a pH value of 10 containing 5.2 GBq Soak in the NaI solution of I-131 for 1 hour, and exchange the radionuclide anion to the inside of the anion resin;

[0074] Get above-mentioned reaction gained reaction solution, measure remaining I-131 activity in the solution with F-613 type radioactivity counter (Beijing Nuclear Instrument Factory), calculate the utilization rate of I-131, then clean resin with water to the pH value of cleaning solution less than 8;

[0075] Add 1 g of I-131-exchanged resin to 20 mL of AgNO containing 1 mg of Ag at pH 3 3 solution, react at room temperature for 3 hours, wash with distilled water until the pH of the washing liquid is 6, then soak in 1mol / L NaOH solution for 4 hours, and filter to obtain...

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Abstract

The invention discloses a radioactive anion resin microsphere and a method for preparing the same, and belongs to the technical field of medicines. The radioactive anion resin microsphere is prepared by curing anionic radionuclide in the anion resin of which the diameter is 5 to 200 mu m and the crosslinking degree is 1 to 20 percent in a precipitation mode. The preparation method comprises the following steps of exchanging the anions of radionuclide to the anion resin, making the radionuclide in the anion resin react with a metal cation precipitator in a solution to form a precipitation in the resin, further curing the radionuclide in the resin and preparing the anion resin microsphere of P-32, I-125, I-131, Re-186 or Re-188. The novel radioactive resin microsphere using anion resin microspheres as a carrier has the characteristics of low release rate of radionuclide, high safety, simple preparation process and the like. The radioactive anion resin microsphere can be used for treating malignant tumors such as liver cancer, lung cancer, tongue cancer and the like.

Description

technical field [0001] The invention discloses a radioactive resin microsphere and a preparation method thereof, in particular to an anionic resin microsphere containing radionuclide P-32, I-125, I-131, Re-186 or Re-188 and its preparation method. The radioactive anion resin microspheres of the present invention are mainly used for internal radiation interventional therapy of malignant tumors such as liver cancer, lung cancer, oral cavity cancer, cervical cancer or tongue cancer. Background technique [0002] Malignant tumors are the number one killer of human health, such as liver cancer, which not only has a high incidence rate, but also is dangerous and difficult to treat, with a high mortality rate. Malignant tumors are difficult to achieve the desired effect by a single treatment method, and often require multidisciplinary comprehensive treatment, such as surgery, chemotherapy, radiotherapy and other means. Among them, radiotherapy mainly uses radiation and ionizing r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/06A61P35/00A61K101/00A61K101/02A61K103/10
Inventor 李明起邓启民尹帮顺潘俊男程作用李茂良王翰
Owner CHENGDU YUNKE PHARMA
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