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84 results about "Thiopyran" patented technology

Thiopyran is a heterocyclic compound with the chemical formula C₅H₆S. There are two isomers, 2H-thiopyran and 4H-thiopyran, which differ by the location of double bonds. Thiopyrans are analogous to pyrans in which the oxygen atoms have been replaced by sulfur atoms.

Imaging members

A member including, for example, a supporting layer and a single photogenerating layer, the photogenerating layer comprising particles including hydroxygallium phthalocyanine phthalocyanine Type V, x polymorph metal free phthalocyanine, or chlorogallium phthalocyanine dispersed in a matrix comprising an arylamine hole transporter and an electron transporter selected from the group consisting of N,N'bis(1,2-dimethylpropyl)-1,4,5,8-naphthalenetetracarboxylic diimide, 1,1'-dioxo-2-(4-methylphenyl)-6-phenyl-4-(dicyanomethylidene)thiopyran, and a quinone selected from the group consisting of carboxybenzylhaphthaquinone, and tetra (t-butyl) diphenoquinone, and mixtures thereof, and submicrometer size polytetrafluroethylene particles, and a film forming binder.
Owner:XEROX CORP

Novel synthesizing method for dorzolamide HCL midbody

The invention relates to a new synthetic method of a dorzolamide intermediate (S)-6-methyl-2-chlorosulfuryl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-carboxide, comprising the steps of synthesizing raceme 3-(thien-2-ylthio)butyric acid, performing chiral resolution to obtain stereoisomer thereof (S)-3-(thien-2-ylthio)butyric acid, and performing addition and ring-closing reactions to obtain (S)-6-methyl-2-chlorosulfuryl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-carboxide. The inventive method shortens conventional synthesis route, and performs chiral resolution of the intermediate raceme at the beginning of the synthesis route with a chiral resolution agent, so as to save a large amount of subsequent raw materials consumption. In addition, the synthetic method adopts 'one-pot' method, so as to reduce loss and the steps and cost of the subsequent operations, resulting in a more convenient, economical and effective synthesis route, compared with the known synthesis routes.
Owner:北京精华耀邦医药科技有限公司

Functionalized polymer, rubber composition and pneumatic tire

The present invention is directed to a functionalized elastomer comprising the reaction product of a living anionic elastomeric polymer and a polymerization terminator of formula Iwhere X is Cl, Br, or I;m is an integer from 0 to 2, n is an integer from 1 to 3, with the proviso that n+m=3;R1, R2 are independently C1 to C18 alkyl, aryl, or a combination thereof, or R1, R2 are independently —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, or R1 and R2 taken together with their common nitrogen atom and optionally a sulfur or oxygen heteroatom to form a five to eight membered ring;R3 is hydrogen, or C1 to C18 alkyl, aryl, or a combination thereof, or R3 is —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, or R3 is —R6—R7, where R6 is C1 to C3 alkanediyl and R7 is selected from the following structures—S—Z, —N(R8)(R9), —O(Y), or Si(OR10)3, where R8 and R9 are independently C1 to C18 alkyl, aryl, or a combination thereof,Y and Z are independently selected from the group consisting of methoxymethyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrofuranyl, tert-butyl, allyl, 1-ethoxyethyl, benzyl, triphenylmethyl, triethylsilyl, triisopropylsilyl, trimethylsilyl, tert-butyl dimethyl silyl, tert-butyl diphenyl silyl, and isopropyldimethylsilyl, andR10 are independently C1 to C4 alkyl;or when m=1, the polymerization terminator may have the formula IIwhere R4, R5 are independently C1 to C18 alkyl, aryl, or a combination thereof, or R4, R5 are independently —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, X and R3 are as defined previously, and k is an integer from 0 to 10.
Owner:THE GOODYEAR TIRE & RUBBER CO

Substituted amino isoxazoline derivatives and their use as anti-depressants

InactiveUS7265103B2BiocideNervous disorderThiopyranSerotonectin
The invention concerns substituted amino isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisozazoline, dihydronaphthalenoisoxazoline and dihydrobenzothiopyranoisoxazoline derivatives substituted on the phenylpart of the tricyclic moiety with primary, secondary and/or tertiary amino groups, according to Formula (I)
wherein X=CH2, N—R7, S or O, R1, R2 and R3 are certain specific substituents, with the proviso that at least one of R1 and R2 is an amino radical of formula N—R10R11 wherein R10 and R11 are each a variety of radicals, Pir is an optionally substituted piperidyl or piperazyl radical and R3 represents an optionally substituted aromatic homocyclic or heterocyclic ring system including a partially or completely hydrogenated hydrocarbon chain of maximum 6 atoms long with which the ring system is attached to the Pir radical and which may contain one or more heteroatoms selected from the group of O, N and S; a process for their preparation, pharmaceutical compositions comprising them and their use as a medicine, in particular for the treatment of depression and/of anxiety and disorders of body weight. The compounds according to the invention have surprisingly been shown to have a serotonin (5-HT) reuptake inhibitor activity in combination with additional α2-adrenoceptor antagonist activity and show a strong anti-depressant activity without being sedative. Compounds according to the invention are also suitable for treating depression, anxiety and body weight disorders. The invention also relates to novel combination of substituted amino isoxazoline derivatives according to the invention with antidepressants, anxiolytics and/or antipsychotics to improve efficacy and/or onset of action.
Owner:JANSSEN PHARMA NV

Application of curcumin analog S5 containing thiapyrone structure in preparation of anti-inflammation drugs

The invention belongs to the field of the pharmaceutical chemistry and pharmacology, and concretely relates to an application of a compound of [(1Z,1'Z)-(4-Oxo-2H-1-thiopyran-3,5(4H,6H)-diylidene)bis(methanylylidene)]bis(2-methoxy-4,1-phenylene)bis(2-methylpropanoate) (S5) in the preparation of anti-inflammation or / and anti-oxidation drugs. The above thiapyrone type curcumin analog S5 can dose-dependently inhibit the expression and release of inflammation factors comprising TNF-alpha, IL-6 and the like, and can also obviously improve the survival rate of mice death-induced by LPS. The compound has a good safety and stability, and can be exploited to inflammation or / and oxidation stress related disease treatment drugs.
Owner:WENZHOU MEDICAL UNIV

4H-thieno[2,3-b]thiapyran-4-ketone compound and application thereof

The invention belongs to the technical field of medicines, and relates to a 4H-thieno[2,3-b]thiapyran-4-ketone compound, a preparation method thereof and application thereof as an epidermal growth factor receptor tyrosine kinase inhibitor. The compound, a prodrug thereof, a pharmaceutically active metabolite thereof and a pharmaceutically acceptable salt thereof have structural formula as shown inthe specification, wherein R is independently selected from hydrogen, halogen, hydroxy, nitro, cyan, C1-C4 alkyl, C1-C4 alkoxy, halogen atoms substituted C1-C4 alkyl, and halogen atoms substituted C1-C4 alkoxy. The formula is shown in the description.
Owner:SHENYANG PHARMA UNIVERSITY

Functionalized polymer, rubber composition and pneumatic tire

The present invention is directed to a functionalized elastomer comprising the reaction product of a living anionic elastomeric polymer and a polymerization terminator of formula I
where X is Cl, Br, or I;
m is an integer from 0 to 2, n is an integer from 1 to 3, with the proviso that n+m=3;
R1, R2 are independently C1 to C18 alkyl, aryl, or a combination thereof, or R1, R2 are independently —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, or R1 and R2 taken together with their common nitrogen atom and optionally a sulfur or oxygen heteroatom to form a five to eight membered ring;
R3 is hydrogen, or C1 to C18 alkyl, aryl, or a combination thereof, or R3 is —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, or R3 is —R6—R7, where R6 is C1 to C3 alkanediyl and R7 is selected from the following structures
—S—Z, —N(R8)(R9), —O(Y), or Si(OR10)3, where R8 and R9 are independently C1 to C18 alkyl, aryl, or a combination thereof,
Y and Z are independently selected from the group consisting of methoxymethyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrofuranyl, tert-butyl, allyl, 1-ethoxyethyl, benzyl, triphenylmethyl, triethylsilyl, triisopropylsilyl, trimethylsilyl, tert-butyl dimethyl silyl, tert-butyl diphenyl silyl, and isopropyldimethylsilyl, and
R10 are independently C1 to C4 alkyl;
or when m=1, the polymerization terminator may have the formula II
where R4, R5 are independently C1 to C18 alkyl, aryl, or a combination thereof, or R4, R5 are independently —SiR3 where R is independently alkyl, aryl, alkoxy, or disubstituted amino, X and R3 are as defined previously, and k is an integer from 0 to 10.
Owner:THE GOODYEAR TIRE & RUBBER CO

Chromogenic medium used for detecting escherichia coli O157:H7

The invention discloses a chromogenic medium used for detecting escherichia coli O157:H7 and other intestinal floras. The medium contains agar, peptone, a yeast extract, sodium chloride, sorbitol, inositol, neutral red, a beta-galactosidase chromogenic substrate, 4-methyl sector ketone-beta-D-glucuronide, isopropyl-beta-D-thiopyran galactoside, bile salt, potassium tellurite and cefixime. The chromogenic medium disclosed by the invention can be used for identifying escherichia coli O157:H7 in coliforms rapidly, simply and conveniently.
Owner:SOOCHOW KH BIO SCI & TECH CO LTD KHB
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