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57 results about "Thiolactone" patented technology

Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common lactones in which an oxygen atom is replaced with a sulfur atom. The sulfur atom is within the ring system and adjacent to a carbonyl group.

Stereoselective total synthesis method of (+)-biotin

The invention belongs to the organic chemistry technical field, in particular to a (+) - biotin stereo-selective full synthesis method. The synthesis method comprises the following steps of preparing meso cyclic anhydride via ring-closing reaction and acyl halide dehydration with diacid as initial materials; preparing (4S, 5R)-half ester under the presence of cinchona alkaloid via enantioselective ring opening; then producing intermediate product (3aS,6aR)-lactone, (3aS,6aR)-thiolactone, (3aS,4S,6aR)-double-benzyl biotin and the derivative of the same via selective reduction, acid promoted cyclization, Fukuyama and coupling reaction and so on; debenzylating and ring opening upon the function of inorganic acid, and producing (+)- biotin via cycization reaction in inorganic base solution upon catalysis of activated carbon. With the synthesis method, raw materials are readily available, reaction conditions are mild and operation is easy; the catalyst used has good stability, is easy to be recycled and is suitable for industrial production.
Owner:FUDAN UNIV

Hg2+ sensor based on upconversion NaYF4 resonance energy transfer and detection method of Hg2+ sensor

The invention discloses an Hg2+ sensor based on upconversion NaYF4 resonance energy transfer and a detection method of the Hg2+ sensor. The detection method provided by the invention comprises the following steps: an ultrasonic micro-emulsion method is utilized for obtaining the water soluble and monodisperse rare-earth upconversion nano-particles with uniform grain sizes, which are superficially modified with rhodamine thiolactone, namely the Hg2+ sensor based on upconversion NaYF4 resonance energy transfer; in the presence of Hg2+, the rhodamine thiolactone decorated on the surfaces of the nano-particles and Hg2+ are specially combined to be conducted for ring opening, a maximum absorption peak at 555nm stimulated by near-infrared light at 980nm and an emission peak of the NaYF4 nano-particles at 543nm are just overlapped to be conducted for resonance energy transfer, and the fluorescent emission peaks of the NaYF4 nano-particles are quickly quenched, so that the aim of qualitatively and quantitatively detecting Hg2+ can be achieved by detecting the fluorescence intensity. Compared with the traditional detection method, the detection method provided by the invention is small in background interference, strong in signal, low in cost, and has the characteristics of fastness, accuracy, high flexibility and high selectivity.
Owner:BEIJING UNIV OF CHEM TECH

Water resistant compositions containing a heterocyclic compound and a compound having a functional group chosen from an amino group and a hydroxyl group

The present invention is directed to water-resistant compositions comprising: a reaction product of at least one heterocyclic compound chosen from thiolactone compounds and their thiocarbonyl analogs, and lactam compounds and their thiocarbonyl analogs; and at least one compound having a functional group chosen from an amino group and a hydroxyl group; and optionally, at least one carrier. These water-resistant compositions are capable of providing or acting as a carrier for delivering benefits to various substrates, for example, keratinous substrates such as skin and hair, while at the same time, imparting durable or long lasting hydrophobicity and / or a protective barrier onto said substrates.
Owner:LOREAL SA

Method of Making Cyclic Polypeptides with Inteins

Methods for producing cyclic polypeptides comprising a lactone or thiolactone ring. In certain cases, intein fusion proteins may be used in a method for biologically producing internally cyclized polypeptides. The new methods enable the construction of cyclic polypeptide libraries that may be screened for the biological activity of cyclic polypeptides. Methods provided may be used, for instance, to produce and optimize novel cyclic peptides for use in treating Staphylococcal infections.
Owner:UNIV OF IOWA RES FOUND

Amide-linked perfluoropolyether thiol compounds and processes for their preparation and use

A perfluoropolyether thiol compound comprises a perfluoropolyether segment, at least one mercapto group (-SH), and at least one intervening divalent carbonylimino moiety (-C(=O)-NR-, wherein R is hydrogen or alkyl). The compound can be produced, for example, by a ring-opening reaction of thiolactones with perfluoropolyether-substituted, primary or secondary amines. The compound can be used, for example, as a polymerization chain transfer agent, as an intermediate for the preparation of functional group-containing fluorochemical derivatives such as disulfides, and as a fluorinated surface treatment.
Owner:3M INNOVATIVE PROPERTIES CO

Cyclodextrin-base nitric oxide donor and method for preparing same

The invention discloses a cyclodextrin-base nitric oxide donor and a method for preparing the same. The cyclodextrin-base nitric oxide donor is shown as a formula (I). The method includes dissolving reaction products of amination cyclodextrin and N-acetyl penicillamine thiolactone in organic solvent; adding nitroso tert-butyl ester into the organic solvents; carrying out complete reaction under certain conditions and then precipitating reaction products by the aid of poor solvents to obtain the cyclodextrin-base nitric oxide donor. The cyclodextrin-base nitric oxide donor and the method have the advantages that the cyclodextrin-base nitric oxide donor prepared by the aid of the method can be widely applied to medicine development, for example, the cyclodextrin-base nitric oxide donor can be used for preparing subcutaneous, intramuscular or intravenous injection, the subcutaneous, intramuscular or intravenous injection can be used for treating cardiovascular diseases, tumor and the like, accordingly, excellent treatment effects can be realized, and the cyclodextrin-base nitric oxide donor and the method have popularization and application value.
Owner:ZHEJIANG UNIV

Process for synthesizing thiolactone

The invention discloses a synthesizing method of (3aS, 6aR)-1, 3-dibenzyl-6H-1H-thiofuran [3, 4-d] imidazole-2, 4-diketone, which is reacted by (3aS, 6aR)-1, 3-dibenzyl-6H-1H-furan [3, 4-d] imidazole-2, 4-diketone in the active thio agent system with phosphorus pentasulfide and acetamide. The invention can recycle the reacting product to save cost greatly, which improves the receiving rate.
Owner:SHAOXING UNIVERSITY

Preparation method of biotin intermediate impurity

The invention provides a preparation method of a biotin intermediate impurity with the structural formal shown in a formula (V). Thiolactone and the Grignard reagent are taken as raw materials, and the high-purity intermediate impurity is obtained through addition and hydrolysis. The preparation method is simple and easy and is particularly suitable for preparation in a laboratory.
Owner:BENGBU BBCA MEDICINE SCI DEV

Medicine for alleviating municipal sewage pipeline blocking and application of medicine

The invention discloses a medicine for alleviating municipal sewage pipeline blocking and application of the medicine. The medicine is prepared from the following components in percentage by mass: 20-40% of a quorum sensing inhibitor, 30-50% of a surfactant and 20-30% of a solubilizer, wherein the quorum sensing inhibitor consists of the following components mixed in percentage by mass: 40-60% of meta-bromo-thiolactone, 20-30% of bromination furanone and 10-30% of AIP compounds. The quorum sensing inhibitor is taken as a main component, the quorum sensing behavior of microorganisms in a sewage pipeline can be inhibited, and thus the microorganisms can be prevented from forming biological membranes to block the sewage pipeline.
Owner:新昌县益旭龙机械科技有限公司

Intermediate N-protection-(2S,4S)-2-[(3-hydroxyl carbonyl)-phenyl amino formyl)]-pyrrolidine-4-thio alcohol of ertabeinan

An N-protective group-(2S,4S)-2-[(3-hydroxycarbonyl)-phenylaminoformyl]- pyrrolidine-4-yl thiol as the intermediate of Ertapeinan is prepared through reaction between trans-4-hydroxy-L-phrrolidine and p-nitrobenzylcarbonyl chloride to obtain N-p-nitrobenzyloxy carbonyl-trans-4-hydroxy-4-hydroxy-L-pyrrolidine, reaction by one-pot method to obtain thiolactone, and reaction on meta-aminobenzoic acid.
Owner:SHANGHAI JIAO TONG UNIV

Polymers functionalized with lactones or thiolactones containing a protected amino group

A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a lactone or thiolactone that contains a protected amino group.
Owner:BRIDGESTONE CORP

Method for producing d-biotin

The production process of d-biotin is one improvement of Sternbach synthesis. The production process includes: the esterification of imidazolone-cis-dicarboxylic acid and methanol in the presence of concentrated sulfuric acid as catalyst to produce racemic monoester; resolution with dextramine; selective reduction of the monoester radical in the resolved matter with sodium borohydride to obtain lactone in required absolute configuration; substitution of oxygen with sulfur in potassium ethyl thioacetate to obtain thiolactone; Grignard reaction to introduce side chain and to obtain keto-olefine acid; hydrogenation with Pd-C catalyst to obtain dibenzyl biotin; and elimination of two benzyl radicals in hot hydroboromic acid to obtain pure optically active d-biotin. The said technological process has short technological path, low cost, simple operation and high yield.
Owner:MIANZHU HANWANG YELLOW PHOSPHORUS SICHUAN CHINA

Preparation method of self-cleaning anti-icing coating based on brush-shaped organic silicon

ActiveCN112430423AStrong adhesionExcellent self-cleaning and antifouling propertiesAntifouling/underwater paintsOther chemical processesCoated surfaceEndcapping
The invention relates to a preparation method of a self-cleaning anti-icing coating based on brush-shaped organic silicon. The preparation method comprises the following steps of: carrying out simplemulti-component click reaction on thiolactone, a diamine compound and monovinyl-terminated polydimethylsiloxane to prepare a dihydroxyl-terminated block, and introducing the dihydroxyl-terminated block into a polyurethane matrix to obtain a brush-shaped organic silicon modified polyurethane coating. The coating with the special structure has the characteristics of low surface energy of organic silicon and strong adhesion between the polyurethane coating and a substrate, and the special brush-shaped structure endows the coating with a special liquid-like surface structure, so that the coating has excellent self-cleaning and anti-fouling properties. The highest tensile strength of the coating can reach 48.62 MPa, the elongation at break of the coating is 1233%, the static water contact angleof the coating is 95 degrees or above, and the minimum ice adhesion force of the surface of the coating can reach 15.4 kPa.
Owner:NORTHWESTERN POLYTECHNICAL UNIV

Thermolatent catalyst and its use in curable compositions

Tin-containing catalysts are provided comprising a compound of formula I.I:L1, L2, L3, and L4 are each independently selected from —O—, —S—, —OC(═O)—, —OC(═S)—, —SC(═O)—, —SC(═S)—, —OS(═O)2O—, —OS(═O)2——N(R6)-, and —OP(═O)(R6)-, wherein R6 represents hydrogen or a monovalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms. R1, R2, R3, R1′, R2′, and R3′ each independently represent a divalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms; and R4, R5, R4′, and R5′ each independently represent hydrogen or a monovalent residue derived from reaction of a respective N—H group with an isocyanate, an ethylenically unsaturated compound, a lactone, a dilactone, a thiolactone, a lactam, a thiolactam, a carboxylic acid or derivative thereof, or an epoxide. Also provided are curable compositions containing these catalysts and methods of controlling the rate of cure of curable compositions.
Owner:PPG IND OHIO INC

Polymers functionalized with lactones or thiolactones containing a protected amino group

A method for preparing a functionalized polymer, the method comprising the steps, of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a lactone or thiolactone that contains a protected amino group.
Owner:BRIDGESTONE CORP

Autoinducer compounds and their uses

The present invention discloses the autoinducer compounds, such as acyl homoserine lactones, acyl homocysteine lactone, acyl thiolactones, furanones or signal peptides, and their use in animal feed additives and animal feeds to improve animal performance.
Owner:PATHWAY INTERMEDIATES

Improved manufacturing method of ertapenem side chain

The invention relates to an improved preparation method of a carbapenem compound ertapenem side chain (disclosed as Formula 1). The method comprises the following step: by using amino-protected thiolactone (disclosed as Formula I) as a raw material, carrying out reaction with 3-aminobenzoic acid under acidic conditions by using single saturated alcohol as a reaction solvent, thereby preparing the target compound. By using the single saturated alcohol as the reaction solvent, the crystal characters of the product are improved, and the production cycle is shortened. The method is economical, safe and environment-friendly, and is more suitable for the industrial production scale.
Owner:HANDAN KANGRUI BIOTECH CO LTD

Method for preparing D-biotin intermediate

The present invention provides a process for the preparation of a thiolactone compound of formula (I) wherein R and R'are independently H, lower alkyl, aryl or acyl groups, which R and R 'are optionally substituted with one or more substituents, or geometric isomers thereof or mixtures thereof. According to the present invention, the process surprisingly provides a stable reaction that results in higher purity and / or yield compared to the process of the prior art.
Owner:DSM IP ASSETS BV

Thermolatent catalyst and its use in curable compositions

Tin-containing catalysts are provided comprising a compound of formula I.I:L1, L2, L3, and L4 are each independently selected from —O—, —S—, —OC(═O)—, —OC(═S)—, —SC(═O)—, —SC(═S)—, —OS(═O)2O—, —OS(═O)2——N(R6)-, and —OP(═O)(R6)-, wherein R6 represents hydrogen or a monovalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms. R1, R2, R3, R1′, R2′, and R3′ each independently represent a divalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms; and R4, R5, R4′, and R5′ each independently represent hydrogen or a monovalent residue derived from reaction of a respective N—H group with an isocyanate, an ethylenically unsaturated compound, a lactone, a dilactone, a thiolactone, a lactam, a thiolactam, a carboxylic acid or derivative thereof, or an epoxide. Also provided are curable compositions containing these catalysts and methods of controlling the rate of cure of curable compositions.
Owner:PPG IND OHIO INC

Anti-pollution antibacterial PTFE oil-water separation membrane and preparation method thereof

The invention discloses an anti-pollution antibacterial PTFE oil-water separation membrane and a preparation method thereof. The preparation method comprises the following steps: 1) reacting DL-homocysteine thiolactone hydrochloride with acryloyl chloride to prepare thiolactone acrylamide; 2) preparing a random copolymer of dimethylaminoethyl methacrylate and thiolactone acrylamide, wherein the number-average molecular weight of the copolymer is 20000 to 50000 Da; 3) immersing the clean polytetrafluoroethylene membrane into a catecholamine / trihydroxymethyl aminomethane solution to deposit for 4 to 24 hours, and then cleaning and drying to obtain a deposited membrane; and 4) dissolving glucosamine and the copolymer into a trihydroxymethyl aminomethane solution, immersing the deposited membrane into the solution for 24 hours, and then cleaning and drying to obtain a modified membrane. The anti-pollution antibacterial PTFE oil-water separation membrane has excellent hydrophilic performance and antibacterial performance, the application range of the polytetrafluoroethylene membrane is expanded, a new thought is provided for functional modification of the surface of the polymer membrane, the operation process is simple and convenient, and special equipment is not needed.
Owner:TIANJIN POLYTECHNIC UNIV

Si-rhodamine B thiolactone, preparation method and applications thereof

The invention discloses a Si-rhodamine B derivative, a preparation method and applications thereof. The provided Si-rhodamine B derivative is Si-rhodamine B thiolactone (Si-RBS for short), and is represented by the structural formula I. The Si-rhodamine thiolactone solution is colorless and fluorescent, and is capable of selectively carrying out color developing and fluorescence triggering reactions with Hg2+. Furthermore, a system with an excellent optical performance can be formed in the colorless solution, and thus the sensitivity and selectivity of Hg2+ detection are both greatly improved. So Si-rhodamine B thiolactone can be used to carry out high sensitive and high selective detection on Hg2+, and the detection can be performed in a mode of absorption spectrum or fluorescence spectrum.
Owner:NAT RESERACH CENT OF GEOANALYSIS +1

Process for the resolution of homocysteine-thiolactone

The present invention relates to a process for the preparation of enantiomerically pure homocysteine-gamma-thiolactone comprising optical resolution of racemic homocysteine-gamma-thiolactone (I) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.
Owner:EDMOND PHARMA SRL

Anti-inflammatory drug and use thereof

The invention discloses an anti-inflammatory drug and use thereof. The drug comprises a chiral compound of formula I, or a pharmaceutically acceptable salt, solvate or deuterate thereof; W and Z are independently selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, monocyclic aryl, monocyclic aryloxy or monocyclic heteroaryl; the substitution means that the substance is substituted by one or more groups selected from halogen, C1-C6 alkyl, nitro, amino or hydroxyl; ring A is selected from monocyclic or bicyclic heteroaryl, C3-C6 lactonic ring, C3-C6 lactam ring and C3-C6 thiolactone ring; and alpha and beta are two chiral sites in the compound, and an absolute configuration of alpha and beta are each independently selected froman S or R configuration. The compound disclosed by the invention has remarkable anti-inflammatory effects and is expected to become a new type of non-steroidal anti-inflammatory drugs.
Owner:CHENGDU SHIBEIKANG BIOLOGICAL MEDICINE TECH CO LTD

Novel preparation method of ertapenem side chain

The invention relates to an innovation-type preparation method of an ertapenem side chain (represented by the formula 1). The method comprises the steps: (1) with amino protected thiolactone (represented by the formula I) as a raw material, under an acidic condition, with SiO2 and gamma-Al2O3 as carriers, and with a catalyst prepared with palladium as an active ingredient, carrying out a hydrogenation deprotection reaction, to obtain deprotected thiolactone (represented by the formula 2); and (2) carrying out a reaction of the compound 2 and m-aminobenzoic acid, to obtain the target compound (represented by the formula 1). With easily-available, relatively-inexpensive and amino protected thiolactone having a mature preparation process as the raw material, the improved palladium catalyst is innovatively used for hydrogenation deprotection, the compound 2 is obtained, and then the compound 2 is subjected to a reaction with m-aminobenzoic acid to prepare the target compound; the preparation method has the advantages of cheap and easily available raw materials, high product yield, low production cost, economy, safety and environmental protection, and is more suitable for industrialized production.
Owner:HANDAN KANGRUI BIOTECH CO LTD

Biotin and preparation method thereof

The invention discloses biotin and a preparation method thereof. The preparation method comprises the following steps: (1) preparing a product 1 and a product 2; (2) preparing a product 3; (3) preparation of thiolactone; (4) preparing an ethanol solution of the Grignard substance; (5) preparing a hydrogenated product ethanol solution; (6) synthesizing biotin; and (7) refining biotin. The invention provides the biotin and the preparation method thereof, the method is safe and environment-friendly, the d-biotin can be simply and conveniently obtained with high yield, the industrial production efficiency of the d-biotin is improved, and the production cost is reduced.
Owner:浙江花园营养科技有限公司

Universal lubrication oil for miniature tillers

The invention relates to universal lubrication oil for miniature tillers. The universal lubrication oil comprises base oil and a plurality of additives. The universal lubrication oil comprises the following components in parts by mass: 89.0-95.0 parts of base oil, 1.0-2.0 parts of ultra-high alkali synthesis calcium sulfonate, 2.0-3.0 parts of overbased sulfurized calcium alkyl phenolate, 1.0-2.0 parts of polyisobutene dibutylene phthalein imine, 1.0-2.0 parts of zinc butyl octyl dithiophosphate, 1.0-1.5 parts of amino thiolactone, 0.7-2.5 parts of a complex antioxidant, 3.5-6.5 parts of a clearing agent and 1.8-3.0 parts of an ash-free dispersing agent. The lubrication oil is used for implementing universality of overall-vehicle lubrication oil of the miniature tillers and the lubrication oil of different miniature tillers; by combining the characteristics of the lubrication oil for the miniature tillers, on the one hand, the key properties such as resisting oxidization and resisting scuffing of cylinder bore are improved; on the other hand, the property excess such as low-temperature requirement is avoided, so that the universal lubrication oil is high in applicability and high in economy.
Owner:CHONGQING JIAZHOU LUBRICATING OIL
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