133 results about "Sciatic nerve palsy" patented technology

A Chinese medicine in the form of powder, pill, tablet, plaster, or medical wine for treating the palsy caused by sciatic nerve, central nerve, etc, hyperosteogeny, myodystrophy, etc is prepared from multiple Chinese-medicinal materials. Its preparing process is also disclosed.

A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multi-channel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were designed for reproducible fabrication of grafts containing several micro-conduits, and further tested in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16 weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast, animals that received the multi-luminal BNI showed multiple nerve cables within the available microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal nerve. In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration through the implant up to 45 days after repair.

Polymeric fibers were microbraided around a mandrel to make a tubular guide tube for nerve regeneration. The polymer used for the fibers was one of poly(L-lactide-co-glycolide) (10:90 PLGA) and chitosan. These polymers are biodegradable and biocompatible. The tubes were studied for their surface morphology and swelling behavior. Biological performance of the tubes was examined in the rat sciatic nerve model with a 12 mm gap. One month after implantation nine out of ten rats showed successful nerve regeneration. Morphometric analysis of regenerated nerves confirmed the quality of the regeneration compatible with those offered by other types of biodegradable nerve guide tubes. The tubes were flexible, permeable and showed no swelling.

The invention discloses barrel-shaped alpha conantokin Bt1.3 and application thereof. The amino acid sequence of the barrel-shaped alpha conantokin Bt1.3 is a sequence 2 in a sequence table; and the nucleotide sequence of a coding gene of the conatokin is a sequence 1 in the sequence table. The connection modes of a disulfide bond of the conantokin are Cys1-Cys3 and Cys2-Cys4; and Cys starting from the amino terminal of the conantokin is respectively marked as Cys1, Cys2, Cys3 and Cys4 in sequence. Experiments prove that: Bt1.3 linear peptide (RKCCSNPACNRYNPAIC) is synthesized by an Fmoc-solid-phase peptide synthesis method, and is folded by one step in buffer solution of NH4HCO3 to form the Bi1.3 conantokin; and analgesic experiments prove that the alpha conantokin has high analgesic activity in rat sciatic nerve hemisection models.

A method for altering operation of a nerve related to a given body condition includes the steps of: laparascopically gaining access to the endopelvic area of the abdomen through the abdominal wall; implanting a multiple channel electrode through the access on endopelvic portions of at least one nerve of the sciatic nerve, the pudendus nerve, or both; and operating the electrode to electrostimulate the at least one nerve.

A tablet for epalrestat for suppressing the transmission speed decreasement of sciatic nerve and coccygeal nerve and the increasement of sorbitol in red cell and sciatic nerve is prepared from lactose, microcrystalline cellulose, low-substituent hydroxypropyl cellulose, carboxymethyl starch sodium magnesium stearate and epalrestat through sequential mixing, granulating, drying, coating and tabletting.

The invention discloses a self-locking acetabular posterior-wall posterior-column anatomical steel plate which comprises a steel plate body, a self-locking bolt and an auxiliary sleeve pipe, wherein the auxiliary sleeve pipe is used for controlling the installation of the steel plate body, and a locking-hole internal thread is respectively manufactured at the tops of a first self-locking hole, a second self-locking hole and a third self-locking hole; an external thread is respectively manufactured on the self-locking bolt and the auxiliary sleeve pipe, and the external thread can be in corresponding spinning fit with the locking-hole internal thread; the design per se permits appropriate torsion and bending in a three-dimensional space, is convenient for molding so as to be better fitted with individualized bones and is used for bearing the moving loads of joints, so that fractures are normally healed, and complications, such as fracture later-looseness, shift, pains, bone stress shielding and the like are reduced; the success ratio of fracture internal fixation operations is improved, the molding in the operations is avoided, the blood loss in the operations is reduced, the anesthetic time is reduced, the infected chances are reduced, and the operative risk is lowered; and the interference of built-in materials for sciatic nerves in the internal fixation of the operations is reduced.

The invention discloses a simple fitness chair, which comprises chair legs, a chair seat and a backrest. A backrest with back massage rollers is installed on the upper part of the chair seat. Rotating arms are installed on the poles on both sides of the backrest. The free ends of the rotating arms A grip bar with a massage ball is installed on the top; a thigh exerciser is installed on the front end of the chair seat, a fixing piece is arranged between the thigh exerciser and the seat, and a compression spring is arranged inside the thigh exerciser, and the two ends of the compression spring are installed There is a silicone massage pad; chair legs are installed on the lower part of the chair seat, and a rotating rod is installed on the inner side of the chair leg through the mounting seat, and a foot support rod is vertically installed on the free end of the rotating rod; between the rotating arm and the support rod, the rotation A torsion spring is arranged outside the rotating shaft between the rod and the mounting seat; this utility model can be widely used in ordinary families or enterprises, and can realize the purpose of exercising the whole body at any time, effectively preventing sciatic nerve diseases or lumbar diseases or mouse hands, and is convenient to use and has great advantages. marketing prospects.

The invention relates to a medical device, in particular to a lumbar booster physiotherapy cord which can cure and ease diseases such as human sciatic nerve, lumbar muscle strain, and lumbar disc protrusion, etc. The cord body is bonded with the four sides of an airbag cavity in the thermal sealing way. Lumbar acupoint magnetic blocks are vertically arranged in the two sides of the central lumbar of the airbag pasted on the body. A traditional Chinese drug bag is crossly arranged on the two sides of the central lumbar of the airbag pasted on the body. The output pipe of an airbag switch is connected with the cord body. The input end of the airbag switch is connected with a gas space through a rubber hose. The gas space is provided with an adjustable pressure maintaining valve and a release valve and a micro-air compressor which are communicated with the gas space. The lumbar booster physiotherapy cord is provided with the airbag cavity which can play the roles of support and massage. The medication point and the magnetic therapy point provided by the lumbar booster physiotherapy cord can play the function of nourishing the kidney and activating the blood flow in order to cure a plurality of lumbar diseases quickly. The lumbar booster physiotherapy cord is suitable for the cure and the ease of the human lumbar diseases.

The invention relates to the general field of electrical activation of non-biological artificial muscles, such as ionic polymeric synthetic artificial muscles, by means of action potentials produced by a biological nerve, such as mammalian sciatic nerve. This invention demonstrates how to stimulate and activate a non-biological muscle such as an ionic polymeric metal composite (IPMC) electro-active artificial muscle with the biological action potential generated by a mammalian nerve such as a rat sciatic nerve. The said invention further presents settings to generate optimal movement and force in artificial muscle due to the application of a nerve action potential. The invention uses the sciatic nerve to generate an action potential, which is subsequently amplified and applied to a cantilever sample of an electro-active ionic polymeric artificial muscle to cause it to bend, flex, and twitch. The sciatic nerve, in this invention, is stimulated by a separate signal to cause it to generate an action potential in the range of hundreds of μV, which is recorded by the electrodes attached to the nerve. These electrodes carry the action potential to an amplifier to amplify it to between 10's of Volts and subsequently are attached to the ionic polymeric artificial muscle to cause it to flex and twitch. Different frequencies of stimulation are tried to optimize the motion and force generated by the polymeric artificial muscles.

The invention discloses a human NF2- / - vestibular schwannoma Schwann cell line and an establishment method thereof. The establishment method includes: A, separating Schwan cells in tumors to obtain human NF2- / - primary Schwann cells (human NF2- / - Schwann cells), and carrying out primary culture; B, establishing immunodeficient mouse sciatic nerve human NF2- / - primary Schwann cell transplanted tumor model; C, collecting transplanted tumors greater than 1 cm in diameter from mouse sciatic nerves by screening; D, separating Schwann cells, and carrying out primary cell culture; E, carrying out five successive generations and more of passage culture; F, performing screening to obtain NF2- / - vestibular Schwann cells which are consistent to human NF2- / - primary Schwann cells and transplanted tumor primary cell strains in cellular form and main biological characteristic and which are capable of infinite passage. The NF2- / - vestibular schwannoma Schwann cell line herein has the success rate of95% and above to grow transplanted tumors.

The invention discloses a spine health-care tendon-regulation bed, which comprises a bracket device, a massaging device, a mechanical operator and a controller, wherein the massaging device has a swinging function and is arranged on the mechanical operator, the mechanical operator is electrically connected with the controller and is arranged on the bracket device, the mechanical operator drives the massaging device to move forwards and backwards, ascend and descend through a mechanical bearing arranged in the mechanical operator, and a motor is controlled by the controller to carry out fascia regulation on the back part and left and right lower limbs. In operation, only the controller needs to be pressed down slightly, then massaging balls can be controlled to prop and massage muscle fasciae correspondingly at the both sides of the spine, and simultaneously, a foot stool can be controlled to push and press the lower limbs, so the waist and back and the lower limb fasciae of the human body are stretched to achieve the effect of relieving the sciatic nerves.

The invention relates to a recovery paste for treating the pain of viscera and physiques. The recovery paste is prepared from the following raw material medicines: toad skins, ground beetles, bamboo leaf seseli roots, prepared semen strychni, Japanese ginseng rhizome, pendulous monkshood roots, Chinese clematis roots, herba siegesbeckiae, glaucousback threewingnut root-barks, prepared kusnezoff monkshood roots, prepared common monkshood mother roots, girald daphne barks, daturas, Chinese azalea fruits, licorice roots, stephania, rhizoma arisaematis, haws, gastrodia rhizome, Chinese prickly ash, pinellia ternata, curcuma zedoaria, curcuma aromatica, olibanum, myrrh, dragon blood, borneol, crabs, peach blossoms, hibiscus flowers, henry clematis roots of leaves, Chinese angelica, dog bones, cornu caprae hircus and buffalo horns. The recovery paste is suitable for treating acute and chronic gastroenteritis, ulcer of duodenal bulbs, diarrhoea, abdominal distension, upset stomach, menoxenia, dysmenorrhea, hyperplasia of mammary glands, sterility after long marriage due to salpingemphraxis, injuries from falls, fracture of a broken bone, sudden sprain in the lumbar region, psoatic strain, pain of chest, back and ribs, relapse of old trauma, swelling, pain and numbness of bone joints of hands and feet, rheumatoid arthritis, cervical and lumbar vertebrae disc herniation, hyperosteogeny, pain of sciatic nerve, lung cancers at early stage, middle stage and late stage, breast cancers, liver cancers, intestine and stomach cancers, blood vessel tumours and cervical carcinoma, and the cure rate is high.

The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as active ingredients, any one or two or more compounds selected from a group consisting of the compound of chemical formula 1, the compound of chemical formula 2, and the acceptable salts thereof.The pharmaceutical composition repairs nerve tissue damaged by herpes zoster to reduce the acute pain caused by herpes zoster, prevents postherpetic neuralgia, and enables a fundamental treatment through the recovery of nerve tissue in the postherpetic neuralgia. Further, the pharmaceutical composition can be effectively used for neuronal damage, including sciatic nerve crushing damage or the like, in a neuropathy including diabetic neuropathy or the like and for neuropathic pain, as well as for a variety of diseases caused by nerve tissue damage, such as brain diseases including strokes or the like.

The invention relates to a device for constructing a sciatic nerve chronic constriction injury model, and belongs to the fields of polymer materials and biomedical devices. A liftable work table and amagnetic control coil system are fixed on a bottom support structure; a fixed device is fixedly connected on the top of the liftable work table; an intelligent constriction structure is located in the fixed device. With structure design of a composite ink with magnetic response performance and specific magnetic domain distribution, a spiral stretchable clamp sleeve is remotely excited to producecontrollable deformation, so the clamp sleeve produces axial contraction; by control of the magnetic control coil system, the stretchable clamp sleeve can produce axial contraction in different degrees, meet the needs of different degrees of multiple deformation required by the chronic constriction model, and improve the accuracy and stability of the model construction.

The invention discloses an application of echinacoside (ECH) in preparation of a medicine for treating neuropathic pain. Experimental results show that when the ECH is used in a safe dosage range, theECH with the dosage of 200 mg / kg can remarkably relieve allodynia and hyperalgesia induced by a sciatic nerve chronic compression injury model, improve histopathological changes of sciatic nerves andregulate protein expression of inflammatory cytokines; and it is proved that the ECH has the effects of relieving the neuropathic pain caused by chronic compression injury and promoting the neural functional recovery.

The invention discloses an MR (magnetic resonance) imaging analysis method for sciatic nerve. The MR imaging analysis method includes the steps of fixing with a coil, scanning, imaging, measuring and tracing, and particularly includes fixing a to-be-tested sample by the coil, scanning the to-be-tested sample which is fixed by the coil through a nuclear magnetic resonance imaging scanner to acquire scanning signals, collecting the scanning signals and subjecting the scanning signals to diffusion tensor imaging to obtain an anisotropy index diagram, an apparent diffusion correlation coefficient diagram and an eigenvalue diagram, measuring on the corresponding diagrams to acquire anisotropy index, apparent diffusion correlation coefficient and eigenvalue, performing fiber tracing reconstruction to the original diffusion tensor image to acquire a fiber tracing diagram. The MR imaging analysis method for sciatic nerve can improve sciatic nerve imaging accuracy and reliability.

The invention relates to application of 7-O-beta-D-acetylation sugar-coumarin compounds in treating chronic neuropathic pains. The 7-O-beta-D-acetylation sugar-coumarin compounds comprise a pharmaceutically acceptable salt, ester or a solvate thereof, and the application relates to the application of the salt, the ester or the solvate in preparing medicaments for treating the chronic neuropathic pains, wherein a glycosyl part is arbitrary pyranose or furanose, the hydroxy of which is totally acetylated; a representative compound is 7-O-beta-D-acetylation glucose-coumarin; and the structural formula is disclosed in the specification. On a classical sciatic nerve chronic compression injury (CCI) model, through single intragastric administration and continuous intragastric administration for 7 days, the compound shows definite treatment effect of resisting nervous pains. At a dose point appointed by an experiment, the compound can obviously improve the mechanical stimulus pain threshold, the nervous pain resistant efficacy is equivalent to that of Gabapentin which is a contrast medicament, and the duration is superior to that of the Gabapentin. Proved by research results, the compound can be used for treating the chronic neuropathic pains.

The invention belongs to the technical field of biological materials and nerve injury repairing, and particularly relates to a decellularized epineurium catheter and a preparation method thereof as well as application to repairing of a peripheral nerve injury. The biological characteristic of the decellularized epineurium catheter for a pig is researched from such aspects as the porosity, the swelling rate, the in vitro degradation rate and the cytotoxicity test, and the immunogenicity of the catheter is also researched. According to the decellularized epineurium catheter and the preparation method thereof, a rat sciatic nerve transversal injury model is built; after being subjected to microsurgical suturing, a nerve stump line is covered with the decellularized epineurium catheter so as to research the effects of promoting regeneration of nerves, preventing nerve adhesion and formation of nerve tumors. The invention provides the decellularized epineurium catheter which can effectively reduce surrounding nerve adhesion and reduce the occurrence rate of the nerve tumors, and a novel repairing material is provided for repairing of war traumatic surrounding nerve injuries and treatment of causalgia caused by the nerve injuries.

The invention provides medicated liquor which is characterized in that each 100g of liquor comprises the following components of 150-180g of anisodus acntangulus, 140-180g of radix aconiti sinensis and 40-60g of rhizome polygonati odorati. The medicated liquor can be used for sterilizing, dispelling poison, diminishing inflammation, relieving pains, promoting blood circulation by removing blood stasis, promoting tissue regeneration, reducing fracture and tranquilizing and allaying excitement as well as is mainly used for treating various tuberculosis, injuries from falls, osteomyelitis, periostitis, rachitis, hyperosteogeny, sciatic nerve, rheumatoid arthritis, scald (burn), biting from poisonous insect, anemia, neurasthenic and the like. The medicated liquor has the advantages of simple preparation methods, easily-obtained raw materials, low cost, complete functions and favorable curative effects.

Repetitive electrical activity produces microstructural alteration in myelinated axons. These transient microstructural changes can be non-invasively visualized via two different magnetic-resonance-based approaches: diffusion fMRI and dynamic T2 spectroscopy in the ex vivo perfused bullfrog sciatic nerves. Non-invasive diffusion fMRI, based on standard diffusion tensor imaging (DTI), clearly localized the sites of axonal conduction blockage as might be encountered in neurotrauma or other lesion types. Diffusion fMRI response was graded in proportion to the total number of electrical impulses carried through a given locus. Diffusion basis spectrum imaging (DBSI) method revealed a reversible shift of tissue water into a restricted isotropic diffusion signal component, consistent with sub-myelinic vacuole formation.

The invention provides a method for isolating and culturing rat Schwann cells, comprising the following steps: (1) disinfecting tissue processing instruments; (2) selecting 2-3 week old male SD rats, killing them by neck dislocation, and using ophthalmic scissors Cut off the hair on the legs of rats, cut off the sciatic nerve, put the tissue into pre-cooled sterile PBS solution containing double antibodies and wash several times to remove blood stains and adventitia; (3) Mince the tissue, and use preheated type II collagen (4) Terminate the digestion, centrifuge, discard the supernatant, add culture medium and resuspend; (5) Inoculate the tissue block into a 6-well culture plate for culture by adherent method; (6) Incubate for 1-2 hours, Placed in a 37°C, 5% CO2 environment for culture; (7) Cell subculture and purification; (8) Cell morphology observation and identification. The method for separating and culturing rat Schwann cells provided by the present invention is simple and easy to operate, stable and efficient, and the obtained Schwann cells have high vigor, which can be used to establish model cells for in vitro experiments and meet the requirements of rat Schwann cell experiments .

The invention belongs to the research and development field of neuro-protective medicament, and discloses a traditional Chinese medicine monomer capable of promoting growth of motoneuron. In the aspect of isolated cell level, the traditional Chinese medicine compound, can obviously promote enation of motoneuron; in the aspect of integral animal level, the compound can obviously promote functional rehabilitation of impaired sciatic nerve and femoral nerve. The invention can be applied to medicinal development for amyotrophic lateral sclerosis and relevant motoneuro symptoms.

The invention relates to a puncture practice device for nurses. A separate water tank with multiple interfaces, a storage battery, a vibration module and a power supply interface with switches are installed in the chest and abdominal cavity of the human body model frame device. Magnetic induction switches are installed on the corresponding positions of the sacral plexus, lumbar plexus, sciatic nerve, femoral nerve, etc., and two booster pumps are installed in the separated water tank and hold liquids of different colors, which are respectively connected to the corresponding silicone arterial tube and silicone venous tube. When you need to practice injection puncture, turn on the switch, the booster pump works, and the water in the separated water tank flows into the silicone arterial tube and the silicone venous tube connected to it. The color of the blood returns to distinguish the arteries and veins. When the corresponding nerve or nerve plexus is pierced, the vibration module starts to vibrate. To achieve the purpose of improving the operation skills by practicing puncture by the simulated person.

The invention provides a melatonin nerve conduit composition and a nerve conduit, as well as a preparation method and application thereof. The composition comprises a biodegradable material, melatoninand a biocompatible adhesive material; various conduits applied to biomedicine are molded by utilizing 3D printing or co-melting of an electrostatic spinning biodegradable material and melatonin or an organic solvent; and after the conduits are molded, a biological adhesive substance layer is printed or coated to the inner wall according to requirements, and cells are induced to differentiate andgrow in conduits. The invention further provides a conduit bracket essential to biology, which is prepared from an ideal biomedicinal functional material, and has the advantages of simple preparation, low cost, easily controlled quality, wide application and the like. Sciatic nerve defect repairing experiments for rats indicate that the melatonin nerve conduit can be used for promoting nerve regeneration, improving maturation of regenerated nerves, increasing the number of effective nerve fibers and promoting functions of sciatic nerves to be restored to normal, has the effect superior to autologous nerve grafting restoration, and has a good application prospect.

The invention belongs to the field of cell biology, and relates to a method for culturing sciatic nerve Schwann cells of adult mouse. The invention also comprises a method for acquiring Schwann cells with high purity through a purification process. The obtained Schwann cells with purity reaching 91% are purified to reach a purity of 98%. Results show that in vitro predegeneration promotes proliferation of the Schwann cells and inhibits fibroblast proliferation, so as to obtain Schwann cells with high purity. The method provided by the invention employs steps of culture and purification of in vitro predegeneration sciatic nerve to simply and effectively obtain a large amount of Schwann cells with high purity, so as to provide abundant high-quality Schwann cells for restoration of injured nerve, and the Schwann cells can be used as seed cells in tissue engineering.

The invention discloses an ergonomic toilet seat. A urea-overflowing-proof flow guide inclined slope is arranged at the center of the front part of the seat, and can be used for preventing urea from flowing out, and draining the urea. Symmetrical sciatic nerve decompression grooves are arranged on two sides of the seat, so that a buffering space is formed when sciatic nerves at lower sections of thighs span across a seat region; and pressure can also be alleviated through a relatively long decompression groove design. A sciatic tuberosity supporting region, which has a bilateral symmetrical design, is arranged on a back inner side of the middle part of the seat; and the pressure on the sciatic nerves is greatly alleviated when a sciatic tuberosity participates in bearing. A stopping pressure splitting inclined slope is arranged at the center of the rear part of the seat and can be used for assisting to stabilize sitting postures and increasing the comfort. A plurality of designs which accord with ergonomics are adopted, so that the pressing on the sciatic nerves of users is reduced as much as possible; and the numbness of lower limbs is avoided, and male users also can avoid the awkwardness of overflowing of the urea.

The invention relates to a sciatic nerve ligation subcutaneous tumor-bearing rat model and application of the sciatic nerve ligation subcutaneous tumor-bearing rat model in screening of analgesic and anti-tumor medicine. Single-side sciatic nerve ligation is conducted on an adult Wistar rat subjected to hypodermic implantation of Walker256 tumor cell suspension, the pain degree of the rat is reflected through spontaneous pain, the mechanical pain threshold value and the hot pain threshold value, and the tumor growth situation is indicated through the body weight change, the tumor formation rate and the tumor size of the rat. After the to-be-detected medicine is applied to the animal model according to the required mode and dosage, and the effect of the to-be-detected medicine on the aspect of analgesia and tumor prevention is judged by observing changes of the indexes. The experimental animal model which has the lasting and stable pain characteristic and can visually measure the tumor growth situation of the tumor of the rat is used for exploring the mechanism of promoting tumor growth through pain and used for screening the novel analgesic and anti-tumor medicine. The new carrier is provided for research and development of the novel analgesic and anti-tumor medicine.

The invention discloses a diabetic peripheral neuropathy treatment medicine and a manufacturing method thereof. The medicine is mainly prepared from radix astragali, radix rehmanniae, rhizoma dioscoreae, angelica sinensis, cornus officinalis, cassia twig, salvia miltiorrhiza, lumbricus and leech. The medicine has efficacies of Qi tonifying, Yin nourishing, kidney tonifying, blood circulation promoting, stasis removing and meridian activating and has functions of reducing blood glucose, increasing microvascular diameter and blood flow volume, increasing sciatic nerve conduction velocity and increasing sural nerve tract area, myelin sheath fiber number and myelin sheath fiber density. The medicine can be used for treatment of diabetic peripheral neuropathy and has advantages of remarkable curative effects, quick action, short treatment period, safety and avoidance of relapse and side effects.