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Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof

A technology of peripheral neuropathy and its production method, which is applied in the field of pharmaceuticals, can solve problems such as large side effects and large differences in curative effects, and achieve the effects of lowering blood sugar, short treatment cycle, and quick results

Active Publication Date: 2016-01-27
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine emphasizes the need to persist in taking medicine for life. Even after spending huge sums of money to place stents, you still need to take expensive medicines for a long time, and the curative effects vary greatly and the side effects are large.

Method used

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  • Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof
  • Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof
  • Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Recipe: mainly composed of astragalus 30g, rehmannia glutinosa 15g, yam 15g, angelica 15g, dogwood 12g, cinnamon twig 6g, salvia miltiorrhiza 12g, earthworm 12g and leech 12g.

[0069] Process: Add 8 times the amount of water to Angelica and Guizhi, steam distillation to extract volatile oil, continuous extraction for 6 hours, collect the volatile oil part, set aside, medicine dregs and water liquid are combined with Astragalus, Rehmannia glutinosa, Cornus officinalis, Chinese yam and Salvia miltiorrhiza 5, add 7 Double the amount of water, extract 3 times, 1 hour for the first time, 1 hour for the 2nd and 3rd time, combine the extracts, filter, vacuum degree 0.01 ~ 0.08Mpa, temperature 50 ~ 70 ℃, the filtrate is vacuum concentrated to For the extract with a specific gravity of 1.2 at 70°C, add 4 times the amount of 95% ethanol to the extract, stir for 1 hour, let it stand for 15 hours, filter the supernatant, and recover the ethanol. Under the condition of 70°C, the me...

Embodiment 2

[0073] Recipe: Astragalus 20g, Rehmannia glutinosa 12g, Chinese yam 12g, angelica 10g, dogwood 8g, cassia twig 4g, salvia miltiorrhiza 8g, earthworm 10g and leeches 10g.

[0074] Process: add 10 times the amount of water to angelica and cinnamon sticks, steam distillation to extract the volatile oil, continue to extract for 10 hours, collect the volatile oil part, set aside, combine the dregs and water with astragalus, rehmannia glutinosa, dogwood, yam and salvia miltiorrhiza, add 10 times Measure water, extract 3 times, 2.0 hours for the first time, 1.5 hours each time for the 2nd and 3rd times, combine the extracts, filter, vacuum degree 0.01-0.08Mpa, temperature 50-70℃, the filtrate is vacuum concentrated to 70 For the extract with a specific gravity of 1.1-1.3, add 2-6 times the amount of 95% ethanol to the extract, stir for 2 hours, let it stand for 24 hours, filter the supernatant, recover the ethanol, and put it in a vacuum of 0.01-0.08Mpa. At a temperature of 50-70°C, ...

Embodiment 3

[0078] Recipe: Astragalus 40g, Rehmannia glutinosa 20g, Chinese yam 20g, Angelica sinensis 20g, Cornus officinalis 15g, Guizhi 8g, Salvia miltiorrhiza 15g, Dilong 15g and leeches 15g.

[0079] Process: add 5 times the amount of water to angelica and cinnamon sticks, steam distillation to extract volatile oil, continue to extract for 3 hours, collect the volatile oil part, set aside, combine the dregs and water with astragalus, rehmannia glutinosa, dogwood, yam and salvia miltiorrhiza, add 2 times Measure water, extract 3 times, 0.5 hours for the first time, 0.5 hours each time for the 2nd and 3rd times, combine the extracts, filter, vacuum degree 0.01-0.08Mpa, temperature 50-70 ℃, the filtrate is vacuum concentrated to 70 For the extract with a specific gravity of 1.1, add 2 times the amount of 95% ethanol to the extract, stir for 0.5 hours, let stand for 8 hours, filter the supernatant, recover the ethanol, in a vacuum of 0.01-0.08Mpa, temperature 50-70 Under the condition of...

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Abstract

The invention discloses a diabetic peripheral neuropathy treatment medicine and a manufacturing method thereof. The medicine is mainly prepared from radix astragali, radix rehmanniae, rhizoma dioscoreae, angelica sinensis, cornus officinalis, cassia twig, salvia miltiorrhiza, lumbricus and leech. The medicine has efficacies of Qi tonifying, Yin nourishing, kidney tonifying, blood circulation promoting, stasis removing and meridian activating and has functions of reducing blood glucose, increasing microvascular diameter and blood flow volume, increasing sciatic nerve conduction velocity and increasing sural nerve tract area, myelin sheath fiber number and myelin sheath fiber density. The medicine can be used for treatment of diabetic peripheral neuropathy and has advantages of remarkable curative effects, quick action, short treatment period, safety and avoidance of relapse and side effects.

Description

technical field [0001] The invention relates to a medicine for treating diabetic peripheral neuropathy and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Diabetic peripheral neuropathy (diabetesperipheralneuro-pathy, DPN) is one of the most common chronic complications of diabetes, and is the main cause of disability in diabetic patients. The prevalence rate in diabetic patients is as high as 60% to 90%. Its pathogenesis has not been fully elucidated, and it is mainly due to long-term severe hyperglycemia that leads to metabolic disorders, microcirculatory disorders, abnormal hemorheology, and autoimmune disorders. The most common damage to the nervous system in diabetes is peripheral nerves. In the early clinical stage, limb numbness, symmetrical lower limb pain, tingling pain and even severe pain are common. Some patients may experience severe pain in the distribution area of ​​peripheral nerves or spinal nerves i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P25/02A61P3/10A61K35/62
Inventor 张莉王天文陈慧黄思行杜伟何晓姣
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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