The invention discloses an
aryl naproxen derivative high-valence
iodine compound, a preparation method and application thereof, wherein a series of
naproxen derivatives are prepared through preparation and
derivatization of
naproxen high-valence
iodine compounds. The compound can realize
nucleophilic substitution reaction of specific sites on naproxen molecule
aryl, so that the purpose of modifying the
drug molecules is achieved, and the variety of the
drug molecules is expanded. The invention also provides a preparation method of the compound, wherein the method comprises the following steps:synthesizing a naproxen derivative, and carrying out anion ligand exchange reaction on the naproxen derivative and a koser
reagent derivative or an
aryl iododiacetic acid compound to prepare the arylnaproxen derivative high-valence
iodine compound. The high-valence iodine compound can perform concise and clear structural modification on naproxen molecular aryl, realizes rapid synthesis of
structural diversity of
drug molecules through accurate modification at specific sites, is convenient for
rapid construction of a huge drug-like compound
library, and greatly promotes the discovery processof naproxen drug active primers.