234 results about "Microcirculation disorders" patented technology

Therapeutic apheresis treatments and diagnostic monitoring methods are described, specifically relating to the depletion and / or removal of a broad bandwidth of certain rheologically active elements from the blood of a patient followed by return of the blood so treated to the patient, and to methods or procedures of apheresis treatment, especially biophysiologic blood filtering treatments and computer medicated delivery methods configured to provide such apheresis treatments to patients with certain chronic, age-related, degenerative, atherogenic, thrombotic or inflammatory diseases; especially those associated with RAM accumulation-deposition causing disturbances of blood rheology or microcirculatory impairment.

A process for extracting cis-ligustilide includes such steps as pretreating, pulverizing, high-shear extracting, separating and purifying. Its advantages are low toxin and high output rate and purity. It can be used in preparing the medicine for prevent and treat the diseases associated with microcirculation disorder.

The invention relates to prostaglandin microemulsion-gel preparation and a preparation method thereof. The preparation comprises prostaglandin E1 or the derivative thereof, oil, emulsifier, assistant for emulsifying agent, gel substrate and water, and also possibly comprises a permeation accelerator, a preparation stabilizer, an antioxidant and antiseptics. The preparation has the advantages of good percutaneous permeability, no stimulation to skin and mucous membrane, simple preparation technique and stable quality, the preparation can be used for treating diseases such as ulcer of limbs caused by erectile dysfunction and chronic arterial occlusion and rest pain of limbs caused by microcirculatory disturbance.

The invention relates to a method and a device for treating vaginitis and adnexitis with ultrasonic wave, which carry out strengthened micro exercise to female vagina and adnexa by using energy of ultrasonic wave so as to promote metabolism of cell tissues of the vagina and adnexa, relax nerves of the vagina and adnexa, improve elasticity and activity of the cell tissues of the vagina and adnexa, increase blood flow of the vagina and adnexa, remove microcirculation obstruction of the vagina and adnexa, and eliminate accumulated water and deposition wastes in the cell tissues of the vagina and adnexa, so that the method for treating vaginitis and adnexitis is realized.

The invention discloses a traditional Chinese medicine steam foot massaging health care instrument, which is mainly composed of a main body, a foot sole massaging device arranged inside the main body, and a steam preparation device and a steam transmission device which are arranged inside the main body and are located below the foot sole massaging device, wherein the steam transmission device comprises an airflow cavity which is formed inside the main body, a steam conduit which is connected between the airflow cavity and the steam preparation device, and a steam conveying device which is arranged inside the airflow cavity and is used for promoting steam circulation. According to the health care instrument disclosed by the invention, traditional Chinese medicines are kept in a traditional Chinese medicine cabin while water is stored in a water adding cabin, and medicine properties can be applied to deep affected parts of patients under the action of steam, so that a curative effect is good; by virtue of an ozone disinfector, the affected parts of foot soles can be disinfected, so that cross infection is avoided; and far infrared rays, which are transmitted from a far-infrared heating film, can radiate feet and calves, so that good effects on improving and treating various diseases caused by blood circulation and microcirculation disturbance in the feet and the calves are achieved.

The present invention discloses liquidambar bacteriostatic bathing liquor with the functions of soothing sinews and quickening channels, eliminating dampness and expelling wind-cold and promoting blood circulation for curing the diseases of traumatic injury, arthralgia due to wind-cold-dampness and others. It is made up using 9 Chinese medicinal materials of liquidambar fruit, ground pine, speranskia / balsam, mugwort leaf, Chinese angelica root and others through a certain preparation process.

The present invention discloses an inclusion complex containing the panaxsaponin Rg2 and the preparation method. The inclusion complex of the invention consists of the panaxsaponin Rg2 and the hydroxypropyl-Beta-cyclodextrin. The preparation method of the present invention is as following. The hydroxypropyl-Beta-cyclodextrin water solution is prepared; the hydroxypropyl-Beta-cyclodextrin solution is kept in the water bath; the extraction powder of the panaxsaponin Rg2 or the extraction of the liquid-typed Rg2 dissoluted by the solvent is added before mixing and complex; therefore the liquid inclusion complex is obtained and the inclusion complex after drying. The inclusion complex of the present invention has functions of increasing the heart perfusion and the blood flow, expanding the diameter of the vein and the artery, improving the microcirculation disturbance, improving the myocardial ischemia and anti-thrombosis effect. The present invention can significantly reduce the acute toxicity of the panaxsaponin Rg2.

The invention relates to a human microcirculation blood perfusion detecting instrument and method. The detecting instrument comprises a laser module, a light probe, a detecting module, a signal processing module and a user interface module. The laser module emits laser signals of preset wavelength to the light probe. The light probe transmits the laser signals emitted by the laser module to human tissue and transmits light signals reflected by the human tissue to the detecting module. The detecting module converts the light signals transmitted by the light probe into corresponding electric signals and transmits the electric signals to the signal processing module. The signal processing module extracts Doppler shift signals from the electric signals and calculates blood perfusion according to the Doppler shift signals. The user interface module displays the blood perfusion visually. The detecting instrument can help doctors or related medical staff find the situation in time and take effective treatment measures when microcirculation disturbance happens to a patient, and therefore health of the patient is ensured.

The invention relates to an external use drug or health product, in particular to an external use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and a preparation method of the external use drug. The method comprises the steps of taking and cutting the four traditional Chinese medicinal materials of saposhnicovia divaricate, radix angelicae pubescentis, longspur epimedium and caesalpinia sappan into segments with the length ranging from 10 mm to 15 mm, mixing liquidambar formosana hance, rhizoma atractylodis, angelica sinensis, folium artemisiae argyi, suberect spatholobus stems, polygonum cuspidatum, eucommia ulmoides, cassia twig and flos carthami with the four traditional Chinese medicinal materials, placing the mixture into a heat reflux extraction tank, adding water for soaking for 1 h, conducting heating reflux extraction for 5 h, concentrating the mixture to until the density ranges from 1.15 to 1.20, conducting drying at the temperature of 80 DEG C, smashing the mixture into fine powder, placing the fine powder into a granulator for granulation, drying the wet granulates, controlling the temperature to range from 40 DEG C to 50 DEG C for 2 min to 3 min, placing the dried granulates into an oscillating granular to be granulated with a 16-mesh screen cloth, and packaging the granulates to obtain the external use drug. The external use drug has the health care function, improves microcirculation, is applicable to people who have waist, leg, shoulder and neck joint pains caused by rheumatism strains and have microcirculation disturbance caused by hyperostosis.

The invention relates to application of total flavones of oldenlandia diffusa willd in preparing drugs for treating meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site. The total flavones of oldenlandia diffusa willd are obtained through the steps that oldenlandia diffusa willd is smashed into crude powder, reflux extraction is conducted with petroleum ether, and degreasing is conducted; residues with petroleum ether volatilized completely are soaked with ethyl alcohol, reflux extraction is conducted twice, filtrate for the two times are combined, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, distilled water is added, the treated filtrated is dispersed into a sample solution, AB-8 type macroporous adsorption resin is applied to the sample solution, elution is conducted with the distilled water, and water liquid is discarded; elution is conducted with 10% ethyl alcohol and then with 80% ethyl alcohol, 80% ethyl alcohol eluant is collected, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, freeze drying and smashing are conducted, and the total flavones of oldenlandia diffusa willd are obtained. According to the application of the total flavones of oldenlandia diffusa willd in preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site, the effect of improving the meningeal microcirculation disturbance and cerebral ischemia is achieved, the total flavones of oldenlandia diffusa willd serving as the only active site are effectively used for preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia, and innovation on treating the meningeal microcirculation disturbance and cerebral ischemia is achieved.

The invention discloses a snake venom wine for treating cardiovascular diseases and a preparation method thereof. The snake wine is prepared by mixing a snake liquid obtained by soaking live garters and vipers in white spirit, a medicine liquid obtained by soaking 24 traditional Chinese medicines such as codonopsis pilosula, astragalus root, medlar, desertliving cistanche and epimedium herb and the like in white sprit, as well as viper venom powder and honey. The snake venom wine is capable of getting through the micro-circulation of a human body, solving the micro-circulatory disturbance of the body and fundamentally treating cardiovascular diseases, such as hemiplegic stroke, cervical spondylosis, scapulohumeral periarthritis, lumbar, arthritis, rheumatism, breast hyperplasia and gout, resulting from the micro-circulatory disturbance. Further, the invention has no poison or side effect and has nutrition and healthcare functions.

The invention relates to an externally applied Chinese herbal medicine treating muscle and joint disease, which is plaster or tincture formed by 14 kinds of Chinese herbal medicine of olibanum, myrrh, safflower, notoginseng, Chinese polyphaga, Chinese clematis, wild aconite, monkshood root, pawpaw, cassia bark, nuxvomica, asarum, clove and rhizomadrynariae. The externally applied Chinese herbal medicine is properly compatible. The externally applied Chinese herbal medicine can infiltrate the focus through joint and skin of human body, warm the spleen and strengthen the kidney, effectively remove muscle and joint tissue and toxin of organs such as liver, kidney, spleen and stomach and microcirculation disturbance and promote muscle and joint tissue to restore. The externally applied Chinese herbal medicine has the advantages of fast efficacy, short course of treatment, high cure rate, simple preparation, convenient use and low treatment cost.

The invention discloses an application of 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside in the preparation of microcirculatory disturbance improvement medicines. The microcirculatory disturbance improvement medicines comprise 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside as an effective active component, and one or more pharmaceutically acceptable auxiliary agents, especially gastrodin and / or water-soluble cyclodextrin derivatives and PEG400 and mannitol, wherein the structural formula of 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside is shown in the specification. The microcirculatory disturbance improvement medicines treat 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside as the effective active component, and are used for improving disturbances caused by cerebral microvascular damages and / or disturbances caused by ischemia reperfusion damages and / or disturbances caused by leukocyte adhesion damages, and / or disturbances caused by peroxides. Normal mice of Kunming species and artificially induced microcirculatory disturbance model mice undergo tail vein injection treatment, and results of the observation of arteriole and venule systole and capillary network under a microcirculatory microscope show that 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside has an obvious expansion effect on the blood vessels of the normal mice, can obviously resist the reduction of the arteriole and venule systole and capillary network opening number of the microcirculatory disturbance model mice and can obviously resist the reduction of the blood flow speed.

The invention provides a medicament for treating idiopathic edema and a preparation method thereof. The medicine contains pure natural plant drugs of angelica, radix bupleuri, atractylis ovata, Alisma orientale, radix paeoniae alba, tuckahoe, grifola, rhizoma cyperi, motherwort, trumpetweed, cassia twig, and the like. In the medicament, the angelica breaks extravesated blood, nourishes new blood and relaxes vain to eliminate dampness; radix bupleuri, tuckahoe and Alisma orientale soothes liver and strengthens spleen for inducing diuresis to alleviate edema; the atractylis ovata, grifola, and the like, invigorates qi and strengthens the spleen, clears damp and promotes diuresis and blood circulation, and recuperates the body function; the plant drugs are combined to free liver qi and strengthen the spleen, smooth collaterals, avoid moisten, and eliminate edema, so as to ensure the effect of sooth liver and strengthen spleen, smooth collaterals and induce diuresis. Research shows that the medicament has the pharmacological actions of inducing diuresis, reducing capillary permeability, improving microcirculatory disturbance and increasing immunologic function, and the like, treats idiopathic edema etiologically and semeiologically, and has the advantages and characteristics of multiple levels and treatment on principal and subordinate of traditional Chinese medicine.

The invention relates to a new application of a traditional Chinese medicine panax notoginseng saponins R1, in particular to prevention and treatment of diseases of diseases induced by microcirculation disturbance with panax notoginseng saponins R1.

The invention relates to an arteriovenous vascular network model, and belongs to the field of capillary vessels. The microcirculation model from the artery to the capillary and then to the vein is established. The reflecting mechanism of the capillary in the microcirculation disturbance is discussed, and the appropriate boundary conditions are set. The relationship between the microcirculation disturbance and the cerebral hemorrhage is explored, and the numerical simulation is reviewed. The hypertension is founded as the internal factor as well as the initial and long-term factor that causes cerebral hemorrhage. Microcirculation disorders due to strong external stimuli and mood swings are a direct factor in the initiation of cerebral hemorrhage, and the common effects of these factors arerisky, and the end of the LSA vessel wall is more prone to rupture of the bleeding with respect to other parts. The arteriovenous vascular network model has made a great contribution to the study of the capillary, which is of great theoretical reference and practical significance to the understanding of the mechanism of the rupture of the large cerebral vessels and the prevention of the cerebral hemorrhage in the case of the microcirculation disturbance.

The invention relates to the new application of a preparation of Chinese traditional medicine, in particular to the improvement effect of blood-nourishing and brain-refreshing granules on the cerebral microcirculatory disturbance. The test data indicate that the blood-nourishing and brain-refreshing granules can restrain the cerebral microcirculatory disturbance and cerebral nerve trauma; and the effect can be related to the restraint on the production and death of the peroxide.

The invention relates to a tanshinone derivative as well as preparation and an application thereof. The derivative has good storage stability, and can be applied to preparation of medicaments for treating or preventing coronary heart disease, angina pectoris, myocardial infarction, arrhythmia, ischemic encephalopathy, and peripheral circulation disturbance diseases, such as microcirculation disturbance, hypertension, hyperlipidaemia and other diseases caused by various arteriosclerosis, angiitis and diabetes mellitus.

The invention discloses a Chinese medical preparation assisting to adjusting blood sugar, relating to the field of traditional Chinese medicines. The medical preparation assisting to adjusting blood sugar is prepared from the following Chinese medical raw materials in percentage by weight: 1g of sealwort, 0.5-1.5g of polygonatum, 0.5-1.5g of salvia miltiorrhiza, 0.5-1.5g of radix astragali and 0.5-1.5g of fruit of glossy privet. Based on experiences for many years, the five Chinese medical herbs are proportionally prepared to effectively assist in adjusting the blood sugar of a patient, not only can the dosage of western medicines be reduced, but also complications caused by the microcirculatory disturbance of the patient can be improved. Proved by more than 30 clinical tests, the dosage of oral antidiabetic drugs in more than 80 percent of cases can be reduced by approximate one third to two thirds without toxic or side effect. The five Chinese medical herbs belong to pharmaceutical / food resources disclosed by the ministry of health, have reasonable prescription and low cost and are suitable for patients suffering from diabetes to use for a long time.

The invention provides a human fibrinogen-like protein 2 prothrombinase immunogenicity peptide and a use thereof. The human fibrinogen-like protein 2 prothrombinase immunogenicity peptide comprises 12 continuous glutamic acid-rich amino acids near by a serine residue located at an exocellular amino terminal locus 91 of human fibrinogen-like protein 2 prothrombinase. An amino acid sequence of the human fibrinogen-like protein 2 prothrombinase immunogenicity peptide is Glu-Glu-Val-Phe-Lys-Glu-Val-Gln-Asn-Leu-Lys-Glu. A monoclonal antibody of the human fibrinogen-like protein 2 prothrombinase immunogenicity peptide can be prepared by an immunological method and can be used as a novel and specific inhibitor of human fibrinogen-like protein 2 prothrombinase. The monoclonal antibody can be usedfor research of adjustment on blood coagulation promotion functions of human fibrinogen-like protein 2 prothrombinase. The monoclonal antibody prepared according to the human fibrinogen-like protein 2 prothrombinase immunogenicity peptide is beneficial for clinic intervention of disease associated with microcirculatory disturbance.

The invention discloses application of 3,4-dihydroxyl-phenyl lactic acid in preparing a medicine treating microcirculatory disturbance. Salvia Miltrorrhiza (SM) is contained in a great number of the prior Chinese medicines used to treat blood vessel diseases, and 3,4-dihydroxyl-phenyl lactic acid(DLA) is one of main active ingredients in the Salvia Miltrorrhiza. The microcirculatory disturbance is mesentery microcirculatory disturbance and is caused by ischemia / reperfusion. The invention also discloses application of the 3,4-dihydroxyl-phenyl lactic acid in preparing a medicine for preventing adhesion of white blood cells caused by the microcirculatory disturbance, a medicine for restoring adhesional white blood cells caused by the microcirculatory disturbance, a medicine for inhibiting exudation of albumin from small veins caused by the microcirculatory disturbance, a medicine for inhibiting degranulation of mast cells caused by the microcirculatory disturbance, a medicine for inhibiting expressions of adersional molecules CD11b and CD18 on neutrophilic granulocytes caused by the microcirculatory disturbance and a medicine for inhibiting generation of peroxides caused by the microcirculatory disturbance.

The invention discloses a small molecule peptide-containing beverage capable of rapidly improving the microcirculation function. According to the beverage capable of improving microcirculation, soybean micropolypeptide, wheat oligopeptide, ginseng peptide, collagen peptide powder, moring wood enzyme, probiotics and other aid materials are organically combined to promote the rapid absorption of small peptides in a human body through scientific and rational matching. The beverage capable of rapidly improving microcirculation can directly increase the circulation power of the human body in the shortest time, activate human cells, soften and clear blood vessels of the whole body, activate body nerves, improve the microcirculation, remove toxins from the body, and assist people to restore normal metabolism, thereby effectively improving the microcirculation of the human body, and for example, the beverage can reduce the concentration of major components of blood lipids such as triglycerides, cholesterol and the like, thereby improving microcirculatory disorders in the cardiovascular system, can also improve immunity, be anti-fatigue, and improve sleep quality, thereby improving neurological microcirculatory disorders.

The present invention belongs to the field of health-care products and particularly relates to a medicinal and edible microcirculation obstacle preventing and curing compound nutrient. The compound nutrient includes the following substances in weight percentages: 20% of soy protein isolate powder, 10% of whey protein concentrate powder, 6.5% of oligochitosan, 6.5% of cordyceps sinensis mycelium powder, 15% of glucan, 6.5% of radix astragali extract, 20% of morinda citrifolia extract powder, 2% of astaxanthin, 2% of lycopene, 9% of apple polyphenols, 1% of dried ginger extract, 0.5% of multivitamin, and 1% of compound probiotic powder. The present invention provides a nutritional powder which is rich in nutrients and contains a variety of antioxidants, and can help improve the body immunity.

An application of the 'Qi-replenishing' Qishen dripping pill in preparing the medicines for preventing and treating the microcirculatory disturbance diseases caused by mast cell degranulating is disclosed.

The invention discloses a glycoside compound as shown in the formula III and a preparation method, composition, application and intermediate thereof. The preparation method of the glycoside compound is simple, expression of VEGF-AmRNAcan be significantly improved, angiogenesis can be effectively promoted, and a reliable guarantee is provided for research of seeking drugs which promote angiogenesisactivity and treat microcirculation disorders such as cerebral infarction, myocardial infarction and lower limb ischemia.

An application of the 'Qi-replenishing' Qishen dripping pill in preparing the medicines for preventing and treating the microcirculatory disturbance diseases caused by albumin leakage is disclosed.

The invention puts forward eye-protecting health care plaster, which comprises active ingredients and absorption-accelerating ingredients. The eye-protecting health care plaster comprises the following ingredients in parts by weight: 2-8 parts of flos buddlejae, 3-8 parts of flos chrysanthemi indici, 5-15 parts of herba menthae, 5-12 parts of ginseng radix, 5-12 parts of stigma croci, 5-12 parts of spica prunellae, 2-10 parts of folium mori, 4-15 parts of semen cassia, 5-15 parts of semen plantaginis, 1-10 parts of radix saposhnikoviae, 1-5 parts of radix salviae miltiorrhizae, 1-6 parts of rhizoma coptidis, 2-7 parts of phellodendri chinensis cortex and 5-13 parts of herba equiseti hiemalis. The invention provides the eye-protecting health care plaster, the prepared eye plaster has mild performance and provides good protection for the eye skin, and meanwhile, the eye-protecting health care plaster has the functions of increasing the blood flow speed of the periphery of eyes, eliminating bulbar conjunctival microcirculation disturbance of the eyes, preventing from forming microcirculation disturbance and effectively alleviating asthenopia. Finally, the eye-protecting health care plaster can obviously improve the ultramicrostructure of lacrimal gland tissues, stimulate the lacrimal gland to increase secretion volume and further improve the stability of the lacrimal film.

The invention belongs to the technical field of enzyme products and particularly discloses an aloe and hawthorn enzyme and a producing method thereof. The aloe and hawthorn enzyme is prepared from, by mass, 50-55% of Aloe vera whole-leaf concentrated juice, 25-32% of traditional Chinese medicine extract and 20-23% of fruit enzyme. The aloe and hawthorn enzyme has the better effects of lowering blood pressure, blood fat and blood sugar, also has the obvious effects of relaxing the bowels, expelling toxin and reducing weight, improves microcirculation, promotes gastrointestinal functions, and enhances body immunity and the like.

The invention relates to the field of plant healthcare formulae, in particular to Ducaoji traditional Chinese medicine plant composition with an effect of improving human microcirculation. The composition is prepared from components in parts by mass as follows: 1-5 parts of rhizoma polygonati, 25-36 parts of panax notoginseng, 25-38 parts of wax gourd, 7-15 parts of jujube (fructus jujubae), 10-20parts of fructus lycii, 0.5-7 parts of artificially cultivated ginseng for five years or less, 18-28 parts of semen coicis, 15-30 parts of longan, 6-14 parts of sea buckthorn, 2-8 parts of rhizoma dioscoreae and 2-7 parts of lentinula edodes, and the components are prepared by fermentation with probiotics. The raw materials are medicinal and edible plants, and the traditional Chinese medicine plant composition is non-toxic and free of side effects and can thoroughly dredge and improve microcirculation disturbance; the traditional Chinese medicine plant composition is prepared by steps as follows: smashing, water addition, sterilization, fermentation, drying, smashing and preparation, and is probiotic fermentation traditional Chinese medicine compound preparation for improving microcirculation disturbance of the human body; the preparation method of fermented traditional Chinese medicine is simple, preparation cost is low, and popularization and application are facilitated.

The invention relates to a medicament for treating or preventing coronary disease, angor pectoris, myocardial infarction, arrhythmia, ischemic brain disease, cerebral thrombosis, cerebral hemorrhage and sequelae thereof, vascular dementia and peripheral circulation disturbance disease, including various artery occlusions, vasculitis, and microcirculatory disturbance caused by diabetes mellitus, high blood pressure, hyperlipidemia and hyperviscosity as well as refractory neck syndrome, vertebrobasilar artery insufficiency and other ischemic diseases accompanying with microcirculatory disturbance, namely, a scutellarin derivative and preparation and application thereof. The derivative has high storing stability, and is suitable for preparing a medicament for treating or preventing heart cerebrovascular diseases.