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Prevention and treatment of diseases induced by microcirculation disturbance with panax notoginseng saponins R1

A technology of microcirculation disorder and Panax notoginseng saponins, which can be used in cardiovascular system diseases, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of unclear prevention and treatment of microcirculation disorders

Inactive Publication Date: 2009-11-11
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, it is not clear whether notoginseng saponin R1 has preventive and therapeutic effects on the main pathological changes of cardiovascular and cerebrovascular diseases—microcirculation disturbance caused by ischemia-reperfusion

Method used

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  • Prevention and treatment of diseases induced by microcirculation disturbance with panax notoginseng saponins R1
  • Prevention and treatment of diseases induced by microcirculation disturbance with panax notoginseng saponins R1
  • Prevention and treatment of diseases induced by microcirculation disturbance with panax notoginseng saponins R1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] tablet

[0056] 【Prescription】Notoginseng Saponin R1 105g Microcrystalline Cellulose 55g Micropowder Silica Gel 3g Magnesium Stearate 1.5g

[0057] [Preparation method] Take the original and auxiliary materials and pass through a 100-mesh sieve; take notoginseng saponin R1, calcium sulfate, and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make a soft material, and pass through a 20-mesh sieve to make granules , dried at 60°C, taken out, sieved through a 30-mesh sieve for granulation, added micropowder silica gel and magnesium stearate, mixed evenly, and pressed into tablets to make 1000 pieces.

Embodiment 2

[0059] 【Prescription】Noginsenoside R1 85g Calcium Sulfate 118g Microcrystalline Cellulose 37g Micropowder Silica Gel 2.4g Magnesium Stearate 1.2g

[0060] [Preparation method] Take the original and auxiliary materials and pass through a 100-mesh sieve; take notoginseng saponin R1, calcium sulfate, and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make a soft material, and pass through a 20-mesh sieve to make granules , dried at 60°C, taken out, passed through a 30-mesh sieve for granulation, added appropriate amount of micro-powdered silica gel and magnesium stearate, mixed evenly, pressed into tablets, and made into 1000 pieces.

Embodiment 3

[0062] 【Prescription】Notoginseng Saponin R1 133g Calcium Sulfate 208g Microcrystalline Cellulose 68g Micropowder Silica Gel 5g Magnesium Stearate 2.5g

[0063] [Preparation method] Take the original and auxiliary materials and pass through a 100-mesh sieve; take notoginseng saponin R1, calcium sulfate, and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make a soft material, and pass through a 20-mesh sieve to make granules , dried at 60°C, taken out, passed through a 30-mesh sieve for granulation, added appropriate amount of micro-powdered silica gel and magnesium stearate, mixed evenly, pressed into tablets, and made into 1000 pieces.

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PUM

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Abstract

The invention relates to a new application of a traditional Chinese medicine panax notoginseng saponins R1, in particular to prevention and treatment of diseases of diseases induced by microcirculation disturbance with panax notoginseng saponins R1.

Description

Technical field: [0001] The invention relates to a new application of the traditional Chinese medicine product notoginseng saponin R1, in particular to the preventive and therapeutic effects of notoginseng saponin R1 on diseases caused by microcirculation disturbance. Background technique: [0002] Ischemia-reperfusion injury is the main pathological basis of injury after interventional therapy, surgery and thrombolysis. Adhesion of leukocytes to vascular endothelial cells and degranulation of mast cells after ischemia-reperfusion are the main pathological links of vascular injury. [0003] Microcirculation is a vascular bed including arterioles, capillaries, and fine veins, which accounts for 90% of blood vessels in the body and is an important part of maintaining metabolism. Hyperlipidemia, high blood pressure, infection, mental stimulation, bruises, surgery, interventional therapy, etc. can all cause microcirculation disturbance. Microcirculatory disturbances include ch...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/14A61P9/10
Inventor 韩晶岩陈卫星王芳刘育英
Owner TIANJIN TASLY PHARMA CO LTD
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