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Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte

A technology of Qishen Yiqi dripping pills and mast cells, applied in the field of medicine

Active Publication Date: 2006-11-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1375316A discloses the composition, preparation method and use of the preparation in angina pectoris of coronary heart disease, but the effect of the drug on anti-mast cell degranulation and improving microcirculation has not been reported yet

Method used

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  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte
  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit degranulation of labrocyte

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 86.5g of astragalus, 21.3g of salvia miltiorrhiza, 3.5g of notoginseng, 20.6g of jiangxiang, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct the crushed salvia miltiorrhiza and Panax notoginseng in water twice, adding 7 times the amount of water each time for 2 hours each time, combining the decoction liquid, filtering, and concentrating the filtrate to 900ml, adding 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the pulverized Astragalus membranaceus twice with water, adding 6 Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml , add 95% ethanol to make the alcohol c...

Embodiment 2

[0040] Get Astragalus 40.6g, Salvia miltiorrhiza 44.8g, Panax notoginseng 11.2g, Dalbergia 38.6g, adjuvant polyethylene glycol-6000 30g, according to the preparation process of embodiment 1, make the traditional Chinese medicine preparation of the present invention.

Embodiment 3

[0042]Get 77.3g of Radix Astragali, 22.8g of Salvia miltiorrhiza, 4.8g of Radix Notoginseng, 30.5g of Jiangxiang, and 28g of polyethylene glycol-6000 as an auxiliary material, and make the traditional Chinese medicine preparation of the present invention according to the preparation process of Example 1.

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Abstract

An application of the 'Qi-replenishing' Qishen dripping pill in preparing the medicines for preventing and treating the microcirculatory disturbance diseases caused by mast cell degranulating is disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Qishen Yiqi dripping pills in the preparation of medicines for inhibiting mast cell degranulation. Background technique [0002] Mast cell degranulation is a complex biochemical process and is affected by multiple stimuli. The classic theory is that after the allergen bridges with the IgE molecule on the surface of the mast cell, the IgE molecule is allosteric, which changes the energy metabolism and permeability of the mast cell membrane, and promotes the process of membrane phospholipid methylation and calcium ion channels. open. The influx of calcium ions in the extracellular fluid may lead to the fusion of the granule envelope and the cell membrane through the activity of microfilaments in the brain plasma (cell muscle action), and together with the mutual fusion between the granule envelopes, a complex pathway connecting the extracellular fluid is form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P43/00
Inventor 韩晶岩李旭郑永峰叶正良
Owner TIANJIN TASLY PHARMA CO LTD
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