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Use of icariin in inducting dry cell body in-vitro directional differentiation
InactiveCN1869204AOpen up new usesResearch helpsNervous disorderNervous system cellsIntellectual propertyDirected differentiation
The invention provides icariin application in inducing stem cell in vitro orientation differentiates to several single type cells. The stem cell said includes embryonic stem cell, nerve stem cell and marrow mesenchyme stem cell. The single type cell includes nerve cell, bone cell, islet cells and endothelial cell. This invention also relates to application of the single type cell in preparing medicine of stem cell transplant curing nerve degenerative diseases, and its application in preparing cell differentiation agent that used to repair recovery injured nerve tissue, and its application in high efficiency drug effect screening model rebuilding and initial screening and estimating by using the model. The new applications of the icariin is extended in this invention, the fact of icariin contains pharmacy activity clarified, so it provides material basis for Chinese traditional medicine prevention and cure effect. The clarifying of drug effect mechanism provides reference for new medicine Chinese metical modern development with self-owned intellectual property right.
Owner:ZHEJIANG UNIV
Ginger and dried orange peel extracts mixture for treating cardiovascular disease
InactiveCN1730094AGood inhibitory effectImproved rheologyCardiovascular disorderPlant ingredientsMedicineBlood pressure
The invention relates to a medicinal mixture for treating cardiovascular diseases, which comprises (by weight portions) ginger extract 100 and dried orange peel extract 1-100 mainly containing ginger volatile oil, gingerol and dried orange peel volatile oil.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Application of rhizoma curculiginis extract in preparing anti-depression medicament
InactiveCN104083549ADevelop medicinal valueOpen up new usesNervous disorderPlant ingredientsReflux extractionMedicine
The invention relates to application of a rhizoma curculiginis extract in preparing an anti-depression medicament, so as to effectively solve the problem of preparing anti-depression medicaments and realizing an application of a rhizoma curculiginis extract in preparing an anti-depression medicament. According to the application of the rhizoma curculiginis extract in preparing the anti-depression medicament, the rhizoma curculiginis extract is prepared by virtue of the following steps: crushing rhizoma curculiginis into coarse powder, soaking with ethanol, and performing reflux extraction; decompressing the filtrate to reclaim ethanol until the liquid does not have ethanol smell, concentrating, and dispersing the concentrate with distilled water to obtain a dispersant; loading the dispersant onto macroporous adsorption resin, eluting with distilled water, and removing the aqueous liquid; continuously eluting with ethanol, and removing the ethanol eluent; eluting with ethanol, collecting the ethanol eluent, reclaiming ethanol in reduced pressure, drying and crushing. The rhizoma curculiginis extract has an anti-depression effect and can be used for effectively preparing the anti-depression medicament, so that the application of the rhizoma curculiginis extract in preparing the anti-depression medicament can be realized.
Owner:HENAN UNIV OF CHINESE MEDICINE
Use of extract of Fructus Pithecellobii clypeoriae conrmon Apes Ear-ring Fruit
The present invention relates to an application of pithecellobium clypearia extract in medicine and food. It adopts pithecellobium clypearia aqueous extract or ethyl alcohol extract as effective component and adds conventional medicinal auxiliary or food additive, and can make them into tablet, capsul, granule preparation, pills preparation and oral liquor preparation. Said pithecellobium clypearia extract has strong inhibition effect for influenza virus, parainfluenza virus, enteric virus, rhinovirus and mumps virus and has strong antioxidation activity.
Owner:SHANHE PHARMA GUANGZHOU CITY
Application of total flavones of oldenlandia diffusa willd in preparing drugs for treating meningeal microcirculation disturbance and cerebral ischemia by serving as only active site
InactiveCN105998276AOpen up new usesImprove microcirculation disorderCardiovascular disorderPlant ingredientsFreeze-dryingMicrocirculation disorders
The invention relates to application of total flavones of oldenlandia diffusa willd in preparing drugs for treating meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site. The total flavones of oldenlandia diffusa willd are obtained through the steps that oldenlandia diffusa willd is smashed into crude powder, reflux extraction is conducted with petroleum ether, and degreasing is conducted; residues with petroleum ether volatilized completely are soaked with ethyl alcohol, reflux extraction is conducted twice, filtrate for the two times are combined, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, distilled water is added, the treated filtrated is dispersed into a sample solution, AB-8 type macroporous adsorption resin is applied to the sample solution, elution is conducted with the distilled water, and water liquid is discarded; elution is conducted with 10% ethyl alcohol and then with 80% ethyl alcohol, 80% ethyl alcohol eluant is collected, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, freeze drying and smashing are conducted, and the total flavones of oldenlandia diffusa willd are obtained. According to the application of the total flavones of oldenlandia diffusa willd in preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site, the effect of improving the meningeal microcirculation disturbance and cerebral ischemia is achieved, the total flavones of oldenlandia diffusa willd serving as the only active site are effectively used for preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia, and innovation on treating the meningeal microcirculation disturbance and cerebral ischemia is achieved.
Owner:HENAN UNIV OF CHINESE MEDICINE
Novel high-conductivity free-cutting selenium copper alloy material and preparation method thereof
The invention discloses a novel high-conductivity free-cutting selenium copper alloy and a preparation method thereof. The alloy is characterized in that the copper alloy comprises the following chemical components by weight percent: 0.2-0.5% of Se, 0.01-0.05% of R, 0.004-0.012% of P and the balance of Cu, wherein R is at least one or two of trace element La and Ce. The preparation method comprises the following steps: smelting, extruding, cleaning, cold machining and annealing. A rod and wire product processed according to the method is characterized in that the tensile strength is more than or equal to 280Mpa, the conductivity is more than or equal to 88% IACS, the cutting processing property is more than or equal to 85% (compared by taking HPb63-3 as 100%), and the ductility is more than or equal to 15%. The copper alloy material has high-strength, high-conductivity and free-cutting properties and can be used for replacing the American mark C14500 product.
Owner:SICHUAN XINJU MINERAL RESOURCE DEV CO LTD
Method for extracting cigarette additives from pre-degreased burdock by ethanol and application thereof
InactiveCN102002437AEfficient removalImprove qualityTobacco preparationTobacco treatmentFlavorAdditive ingredient
The invention discloses a method for extracting cigarette additives from pre-degreased burdock by ethanol and application thereof, which belongs to the technical field of cigarette spice extraction. The method is carried out according to the following steps of: 1. crushing the burdock into coarse powder sieved by a sieve of 100 meshes, adding 6 to 10 times of quantity of medical level sherwood oil with the boiling range between 60 and 90 DEG C and soaking overnight, carrying out back flow extraction for 3 to 5h, filtering materials, remaining filter residue and drying the filter residue in the air; and 2. extracting the filter residue by 60 percent to 85 percent ethanol. The extraction method is the soaking extraction method or the ultrasonic extraction method or the back flow extraction method. A series of substances with better effect on the aesthetic quality of tobacco can be obtained through the extraction method, and the invention also enables medical ingredients of the burdock to be fully utilized.
Owner:HUBEI CHINA TOBACCO IND +1
Water purifying agent specially used for waste water treatment and preparation method of water purifying agent
ActiveCN108557943AFormulation ScienceReasonable formulaWater/sewage treatment using germicide/oligodynamic-processWater/sewage treatment by flocculation/precipitationSodium BentonitePotassium fluoride
The invention discloses a water purifying agent specially used for waste water treatment. The water purifying agent is prepared from the following raw materials in parts by weight: 10-20 parts of bentonite, 15-25 parts of kaolin, 8-14 parts of modified attapulgite, 6-12 parts of aluminum hydroxide, 5-10 parts of sodium hydroxide solution, 6-11 parts of hydrochloric acid, 7-13 parts of activated coal ash, 3-7 parts of calcium carbonate, 2-5 parts of potassium alum, 3-8 parts of Chinese yam, 5-9 parts of active carbon, 0.2-0.6 part of hydrogen peroxide, 0.3-0.7 part of pore-enlarging agent, 1-2parts of dispersing agent, 1-2 parts of bactericide and a proper amount of water, wherein the activated coal ash is prepared through mixing common coal ash with potassium fluoride and then placing ina high-temperature environment to roast; the mass fraction concentration of the sodium hydroxide solution is 30%. The water purifying agent specially used for waste water treatment is scientific and reasonable in formula, good in purification performance, low in cost and good in stability, and can be used for large-scale industrial production.
Owner:广州市芦苇环保科技有限责任公司
P-hydroxyphenyl propanoic acid extracted from white mulberry root barks as well as preparation method and application thereof
InactiveCN106588642ANovel preparation methodEasy to operateAntipyreticAnalgesicsP-hydroxyphenylpropionic acidThin-layer chromatography
The invention relates to p-hydroxyphenyl propanoic acid extracted from white mulberry root barks as well as a preparation method and an application thereof to effectively solve the problems of extracting the p-hydroxyphenyl propanoic acid from the white mulberry root barks and applying the p- hydroxyphenyl propanoic acid to preparation of medicines for treating LPS (lipopolysaccharide) induced HPAEC (Human Pulmonary Artery Endothelial Cells) injuries. The preparation method comprises the following steps: performing decoction extraction on the white mulberry root barks; performing vacuum concentration on an extract to obtain a dried product; adding distilled water into the dried product to perform suspension; performing treatment on a resin column; performing gradient elution by using water and ethanol in sequence; concentrating eluant of each gradient until the eluant is dried; dissolving the dried product by using methanol; adding silica gel; adding the mixture to the liquid surface of a chromatographic column; performing gradient elution; performing TLC (thin layer chromatography) analysis and combination on each fraction; performing vacuum concentration to obtain gross samples A1, A2 and A3; and dissolving the gross sample A1 by using methanol, performing treatment on a Toyopearl HW-40 column, performing elution by using methanol, performing thin layer detection and combination to obtain a fraction A1-2, performing vacuum concentration and drying, performing dissolution by using methanol, performing treatment on an ODS (octadecylsilyl) column, performing elution by using methanol, performing thin layer detection, combining parts containing the same fractions, and performing vacuum concentration to obtain the p-hydroxyphenyl propanoic acid. The method provided by the invention is novel and unique, is easy to operate and use, and opens up a new application of the white mulberry root barks.
Owner:HENAN UNIV OF CHINESE MEDICINE
Method for extracting anti-cerebral-ischemia material from roses and application of anti-cerebral ischemia material
InactiveCN103417679BHas anti-ischemic effectOpen up new usesCardiovascular disorderPlant ingredientsReflux extractionReflux
Owner:HENAN UNIV OF CHINESE MEDICINE
Novel pH-responsive fluorescent molecular probe and preparation method thereof
InactiveCN103980885AOpen up new usesOrganic chemistryFluorescence/phosphorescenceFluorescenceNitrogen
The invention relates to a pH-responsive fluorescent molecular probe with a chemical name, namely, 5-(2-phenyl-pyrrolo[2,1,5-cd]indolizine-5-yl)-1,3,4-oxadiazole-2-thiophenol, as well as a preparation method and application thereof. According to the preparation method, a mercapto group is adopted as an identifying group and an indolizine group is adopted as a signal group for the first time to successfully prepare the compound. By virtue of the fluorescent probe molecules, a sensitive identification of H<+1> under different pH values is realized, the types of the pH-responsive fluorescent molecular probe are enriched, and a novel use of the mercapto functional group is opened up. The pH-responsive fluorescent molecular probe has very broad industrial application prospects and provides valuable reference to make a scientific research.
Owner:NANJING NORMAL UNIVERSITY
Application of mulberry fruit extract in preparation of hypoglycaemic agent
InactiveCN104189088AHas hypoglycemic effectHigh medicinal valueMetabolism disorderPlant ingredientsMedicinal herbsSocial benefits
The invention relates to application of mulberry fruit extract in preparation of a hypoglycaemic agent and aims at effectively solving the problem of preparation of the hypoglycaemic agent, further developing a new medicine used for treating diabetes and realizing new application of the mulberry fruit extract in the preparation of the hypoglycaemic agent. The mulberry fruit extract is obtained by the following steps: taking dry mulberry fruit medicinal material, smashing into coarse powder, adding ethyl alcohol the weight of which is 10 times that of the powder for extracting twice, filtering, putting extracting solutions together, carrying out reduced pressure concentration until no alcohol taste exists, thus concentrate is obtained, adding distilled water into the concentrate, dispersing to obtain dispersion liquid; causing the dispersion liquid to pass through macropore adsorption resin, firstly eluting with distilled water, and discarding water; continuously eluting with ethyl alcohol with the mass concentration of 10%, and discarding eluate; then eluting with ethyl alcohol with the mass concentration of 80%, collecting ethyl alcohol eluate with the mass concentration of 80%, carrying out pressure reduction for recycling ethyl alcohol, drying, and smashing, so that the mulberry fruit extract is obtained, wherein mulberry fruit total flavonoid content is more than 60%. Raw materials are rich, a preparation method is simple, and the obtained mulberry fruit extract has hypoglycaemic effect, can be used for preparing the hypoglycaemic agent and has good economic and social benefits.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of graphene and molybdenum disulfide composite material as electromagnetic wave absorption material
ActiveCN105428820AAbsorption BandwidthStrong absorption capacityAntennasCvd grapheneMolybdenum disulfide
The invention discloses an application of a graphene and molybdenum disulfide composite material as an electromagnetic wave absorption material. The invention furthermore discloses the electromagnetic wave absorption material which is the graphene and molybdenum disulfide composite material. The graphene and molybdenum disulfide composite material can be used as the electromagnetic wave absorption material and is applied to electromagnetic shielding or electromagnetic protection measures, a new application of the graphene and molybdenum disulfide composite material is opened up, and a new choice is provided for the electromagnetic wave absorption material; and the electromagnetic wave absorption material provided by the invention has relatively high electromagnetic wave absorption performance and is a novel wave absorption material with light weight, wide absorption frequency band and good absorption capability.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Preparation method of fructus forsythiae extract lignan and application of extract in blood sugar reducing drugs
ActiveCN103432207AHas hypoglycemic effectAbundant raw materialsMetabolism disorderPlant ingredientsReflux extractionAlcohol
The invention relates to a preparation method of a fructus forsythiae extract lignan and an application of the extract in blood sugar reducing drugs. The problem that a substance for preparing the blood sugar reducing drugs can be extracted from fructus forsythiae can be effectively solved. The extract is obtained through the following steps of crushing fructus forsythiae into medical powder, soaking the medical powder in ethanol for 0.5 h, carrying out reflux extraction twice, abandoning filter residue to obtain an extract liquid, performing decompression concentration on the extract liquid until no alcohol smell is left, adjusting the concentration of the medical liquid to be equivalent to contain 0.5 g / ml of a crude drug, thereby obtaining a sample liquid; applying the sample liquid to a type AB-8 macroporous adsorption resin column; eluting by using water in an amount which is 8 times of the volume of the column to obtain and abandon an eluate I; next, eluting by using ethanol in an amount which is 8 times of the volume of the column so as to obtain and abandon an eluate II; and finally, eluting by using ethanol in an amount which is 10 times of the volume of the column so as to obtain an eluate III, recovering the ethanol, and then carrying out decompression concentration and drying to obtain the fructus forsythiae lignan. According to the invention, the raw materials are rich, the preparation method is simple, the prepared fructus forsythiae lignan has the effect of reducing blood sugar and can be effectively used for preparing the blood sugar reducing drugs; therefore, a new application of treating diabetes is developed.
Owner:HENAN KANGHUA PHARMA
High-strength high-conductivity free-cutting copper alloy material and preparation method thereof
The invention discloses a high-strength high-conductivity free-cutting copper alloy material and a preparation method thereof. The copper alloy material is characterized by comprising the following chemical components in percentage by weight: 0.6-1.5 percent of Pb, 0.6-1.5 percent of Ni, 0.1-0.5 percent of P, 0.01-0.05 percent of R and the balance of Cu, wherein R is either or both of trace elements, i.e., lanthanum and cerium. The preparation method comprises the steps of smelting, extruding, cleaning, cold working and annealing. The tensile strength of a processed bar product is 550-620MPa, the yield strength is 490-560MPa, the electrical conductivity is more than or equal to 50 percent IACS, the cutting machining performance is 70 percent (compared with 100 percent of HPb63-3), and the elongation percentage is more than or equal to 3 percent. The copper alloy material has the properties of high strength, high conductivity, free cutting and the like, and a production process is nontoxic and environment-friendly, so that the copper alloy material can be used for replacing a beryllium-copper material along with which extremely toxic substances are produced in a production process,.
Owner:四川鑫炬新兴新材料科技有限公司
Method for extracting additive from geotrichum candidum fermented burdock by using alcohol and application of additive
InactiveCN102002438AIncrease the sour aroma of cigarette agingLess irritatingTobacco preparationTobacco treatmentFlavorNicotiana tabacum
The invention discloses a method for extracting an additive from geotrichum candidum fermented burdock by using alcohol and application of the additive, belonging to the technical field of cigarette spice extraction. In the method, geotrichum candidum with the capacity of efficiently degrading grease is adopted to ferment the burdock, and then the alcohol is utilized to extract the burdock to obtain an alcohol extract. The invention also provides the application of the alcohol extract from the burdock extracted by using the alcohol to the cigarette additive. The method for extracting can effectively degrade the grease component which is not beneficial to cigarette sense organs and generate micromolecular acid components which are beneficial to the cigarette sense organs; the obtained additive contains a large number of fragrant substances required by tobacco and a few substances influencing the tobacco smoking taste and quality. The alcohol extract obtained by the extracting method is applied to the tobacco to take the effect of improving the tobacco product quality.
Owner:HUBEI CHINA TOBACCO IND +1
Application of fructus cnidii general flavone in preparation of medicines for treating perimenopausal syndrome
InactiveCN106236799AOpen up new usesAbundant raw materialsSexual disorderPlant ingredientsAlcoholMedicine
The invention relates to application of fructus cnidii general flavone in preparation of medicines for treating perimenopausal syndrome, aiming at effectively solving the application problem of preparing perimenopausal syndrome medicines from fructus cnidii general flavone which serves as a unique active ingredient. The fructus cnidii general flavone is prepared by the following steps: grinding fructus cnidii into coarse powder; refluxing and extracting with petroleum ether, and degreasing; volatizing petroleum ether from fructus cnidii dregs, soaking in ethanol, refluxing and extracting, and filtering; reclaiming ethanol at reduced pressure until no alcohol smell exists; dispersing with distilled water to obtain a liquid medicine; passing the liquid medicine onto AB-8 type macroporous adsorption resin; eluting with distilled water, and removing water elution; eluting with ethanol having a mass concentration of 10 percent, and removing the elution; eluting with ethanol having a mass concentration of 80 percent, collecting the 80% ethanol elution, and reclaiming ethanol at reduced pressure until no ethanol smell exists; freeze-drying, and grinding to obtain the fructus cnidii general flavone. The fructus cnidii general flavone is rich in raw materials, simple in preparation method, easy to operate and high in preparation efficiency, can be used for effectively preparing medicines for treating the perimenopausal syndrome, and opens new application of fructus cnidii.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of sharpleaf galangal fruit general flavones in preparation of medicines for treating premenopausal syndrome
InactiveCN106138955AOpen up new usesAbundant raw materialsSexual disorderPlant ingredientsReflux extractionFlavor
The invention relates to application of sharpleaf galangal fruit general flavones in preparation of medicines for treating premenopausal syndrome. According to the invention, the application problem of sharpleaf galangal fruit general flavones serving as the unique active ingredient in preparation of medicines for treating premenopausal syndrome can be effectively solved. The sharpleaf galangal fruit general flavones can be prepared by the following steps: grinding sharpleaf galangal fruit into coarse powder, performing reflux extraction by using petroleum ether, degreasing, volatilizing and drying petroleum ether from sharpleaf galangal fruit residues, adding ethanol for soaking, performing reflux extraction, filtering, recovering ethanol under reduced pressure until alcohol flavor is removed, and adding distilled water for dispersing, thereby obtaining the liquid medicine; adding the liquid medicine on AB-8 type macroporous resin, eluting by using distilled water, and removing water elution; eluting by using ethanol with mass concentration of 10%, and removing the elution; and eluting by using ethanol with mass concentration of 80%, recovering ethanol under reduced pressure until alcohol flavor is avoided, performing freeze drying, and grinding, thereby obtaining the sharpleaf galangal fruit general flavones. The sharpleaf galangal fruit general flavone disclosed by the invention is simple in preparation method, easy to operate and high in production efficiency, and is effectively used for preparing medicines for treating premenopausal syndrome.
Owner:HENAN UNIV OF CHINESE MEDICINE
Preparation method and application of eupatorium japonicum extract
InactiveCN102133263AOpen up new usesExploitationUrinary disorderPlant ingredientsReflux extractionMedicine
The invention relates to a preparation method and application of eupatorium japonicum extract, which can effectively realize the purposes of preparation of eupatorium japonicum extract and preparation of medicaments for treating prostatitis and prostatic hypertrophy. The technical scheme for realizing the purposes comprises the following steps of: chopping eupatorium japonicum, adding 95% ethanol the weight of which is 10 times of the weight of the eupatorium japonicum, soaking, carrying out reflux extraction, filtering, and collecting the filtered solution; adding 90% ethanol the weight of which is 8 times of the weight of the eupatorium japonicum into medical residues, carrying out reflux extraction, and filtering; and mixing the two filtered solutions, volatilizing the ethanol, and recovering the ethanol to obtain the eupatorium japonicum extract. The extract can be effectively used for preparing medicaments for treating prostatitis and prostatic hypertrophy, thereby realizing the application of the eupatorium japonicum extract in preparation of medicaments for treating prostatitis and prostatic hypertrophy. In the invention, the raw materials are rich, the preparation method is simple, and the extract is fully used for preparing medicaments for treating prostatitis and prostatic hypertrophy, thereby developing the new application of eupatorium japonicum and realizing the innovation in the traditional Chinese medicine.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of rabdosia rubescens extract in preparation of hypoglycemic agent
InactiveCN104083436AEasy to prepareAbundant raw materialsMetabolism disorderPlant ingredientsReflux extractionPetroleum ether
The invention relates to an application of a rabdosia rubescens extract in preparation of a hypoglycemic agent, effectively solving the problem of treatment pharmacy of hyperglycemia. According to the application of the rabdosia rubescens extract in preparation of the hypoglycemic agent, the extract is prepared by the steps of grinding rabdosia rubescens into coarse powder; carrying out reflux extraction with petroleum ether; discarding a petroleum ether liquid; volatilizing petroleum ether with rabdosia rubescens decoction dregs; soaking with ethanol, carrying out reflux extraction to obtain a filtrate; decompressing and recycling the filtrate till no alcohol taste is available; concentrating to obtain a concentrated liquid; adding distilled water to the concentrated liquid for dispersion so as to obtain a dispersion liquid containing 0.1 g / ml of crude drug; eluting an AB-8 type macroreticular resin column on which the dispersion liquid is put with distilled water; discarding a liquid; eluting with ethanol; discarding an ethanol liquid; eluting with ethanol again; decompressing an ethanol eluant to recycle ethanol; and drying to obtain the rabdosia rubescens extract. The rabdosia rubescens extract has hypoglycemic effects and is effectively used for preparing the hypoglycemic agent; and the application of the rabdosia rubescens extract in preparation of the hypoglycemic agent is realized.
Owner:HENAN UNIV OF CHINESE MEDICINE
A novel pH-responsive fluorescent molecular probe and its preparation method
InactiveCN103980885BOpen up new usesOrganic chemistryFluorescence/phosphorescenceFluorescenceNitrogen
The invention relates to a pH-responsive fluorescent molecular probe with a chemical name, namely, 5-(2-phenyl-pyrrolo[2,1,5-cd]indolizine-5-yl)-1,3,4-oxadiazole-2-thiophenol, as well as a preparation method and application thereof. According to the preparation method, a mercapto group is adopted as an identifying group and an indolizine group is adopted as a signal group for the first time to successfully prepare the compound. By virtue of the fluorescent probe molecules, a sensitive identification of H<+1> under different pH values is realized, the types of the pH-responsive fluorescent molecular probe are enriched, and a novel use of the mercapto functional group is opened up. The pH-responsive fluorescent molecular probe has very broad industrial application prospects and provides valuable reference to make a scientific research.
Owner:NANJING NORMAL UNIVERSITY
Application of spanishneedles herb extract in preparation of hypoglycemic agent
InactiveCN104189044AAbundant raw materialsEasy to prepareMetabolism disorderPlant ingredientsHerbFlavones
The invention relates to application of spanishneedles herb extract in preparation of a hypoglycemic agent, effectively solving a problem of hypoglycemic agent preparation. According to the application of the spanishneedles herb extract in preparation of the hypoglycemic agent, the spanishneedles herb extract is obtained by the following steps: taking dried spanishneedles herb, crushing the spanishneedles herb into crude powder, adding the crude powder into alcohol for soaking, refluxing and extracting twice, filtering, combining filtrate, recycling alcohol under reduced pressure until alcohol smell does not exist, concentrating the filtrate into concentrated liquor with relative density of 1.10-1.20 at 50 DEG C, adding distilled water into the concentrated liquor for dispersing the concentrated liquor into a dispersion liquid; placing the dispersion liquid onto a macroporous adsorption resin column, eluting by distilled water, discarding eluant, further eluting by 10% alcohol, discarding the eluant and then eluting with 70% alcohol, collecting the eluant, recycling alcohol under reduced pressure, drying and pulverizing to obtain the spanishneedles herb extract, wherein the content of the general flavones of the spanishneedles herb is over 55%. According to the invention, the raw materials are rich, the preparation method is simple, and the prepared products have hypoglycemic effects and can be used for preparing the hypoglycemic agent, so that the application of the spanishneedles herb extract in preparation of the hypoglycemic agent is realized.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of deferoxamine to preparation of medicine for preventing and/or treating tumor
ActiveCN109316474AGood treatment effectIncrease lethalityAmide active ingredientsAntineoplastic agentsTherapeutic effectOncology
The invention provides application of deferoxamine to preparation of medicine for preventing and / or treating tumor, and relates to the technical field of tumor science. According to the application ofdeferoxamine to the preparation of medicine for preventing and / or treating the tumor, the dose form of the medicine is an injection or a tablet; the tumor is glioma or human lung carcinoma cells. Inthe medicine, 125 to 500 mumol / L of deferoxamine and 100 mumol / L of temozolomide are contained. Through experiment methods, the result proves that the treatment effect of the temozolomide on the glioma or human lung carcinoma cells can be enhanced; the effect of cooperating with temozolomide to killing glioma or human lung carcinoma cells is achieved; the killing effect of the temozolomide on theglioma or human lung carcinoma cells can be enhanced. The deferoxamine and the temozolomide are prepared into medicine used for preventing and / or treating the glioma or human lung carcinoma cells; thetreatment effect of the temozolomide on the brain glioma or human lung carcinoma can be improved.
Owner:葛鹏飞
Application of total flavonoids of pueraria lobata in preparation of medicines for treating repeated ischemia
InactiveCN107441152APrevent extractionOpen up new usesCardiovascular disorderPlant ingredientsDrug contentFreeze-drying
The invention relates to application of total flavonoids of pueraria lobata in preparation of medicines for treating repeated ischemia. The problem that the total flavonoids of pueraria lobata are extracted from pueraria lobata and serve as the unique active ingredient in the preparation of the medicines for treating repeated ischemia can be effectively solved. The total flavonoids of pueraria lobata are prepared by the steps: grinding the pueraria lobata into coarse powder, performing reflux extraction with ethyl ether and degreasing, and removing the ethyl ether; volatilizing the ethyl ether from decoction dregs of the pueraria lobata, adding ethanol with a mass concentration of 80% for soaking, performing reflux extraction filtering, recovering the ethanol from the filtrate under reduced pressure until any alcohol does not exist, adding distilled water to disperse until dispersion equivalent to 0.3g / mL of the raw drug content is obtained, enabling the dispersion to pass through an AB-8 type macroporous resin, sequentially eluting with the distilled water, ethanol with the mass concentration of 10% and ethanol with the mass concentration of 80%, collecting the 80% of ethanol eluent, performing reduced pressure recovery on the ethanol until any alcohol does not exist, performing freeze drying, and grinding, thereby obtaining the total flavonoids of pueraria lobata. According to the preparation method disclosed by the invention, the total flavonoids of pueraria lobata can be effectively extracted from the pueraria lobata and are effectively used for treating the repeated ischemia, the novel application and medicinal values of the pueraria lobata are developed, and obvious economic and social benefits are achieved.
Owner:HENAN UNIV OF CHINESE MEDICINE
Method for co-producing fatty acid methyl ester, vitamin E and phytosterol from carclazyte oil
InactiveCN105695105AMining economic valueRealize added valueFatty acid esterificationSteroidsSterolDistillation
The invention discloses a method for co-producing fatty acid methyl ester, vitamin E and phytosterol from carclazyte oil.The method comprises the steps that firstly, fatty acid in the carclazyte oil is completely converted into fatty acid methyl ester; secondly, fatty glyceride in the carclazyte oil is converted into fatty acid methyl ester, and then fatty acid methyl ester is obtained through reduced-pressure distillation; thirdly, after ester residues are processed through freezing crystallization to obtain a first batch of coarse sterol, the vitamin E is obtained through molecular distillation, freezing crystallization is performed again to obtain a second batch of coarse sterol, two batches of the coarse sterol is washed with acetone and then dried, and a sterol product is obtained.According to the method, secondary development on the carclazyte oil extracted from a byproduct waste carclazyte generated during grease processing is achieved, not only is the carclazyte oil used for producing fatty acid methyl ester, but also the ester residue byproduct generated in the producing process is further recycled and utilized, the high-economic value natural vitamin E and phytosterol of the byproduct are extracted and recycled, the economic value of the carclazyte oil is excavated in a maximized mode, and the additional value of the carclazyte oil is achieved.
Owner:常州市金坛区维格生物科技有限公司
Application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines
InactiveCN110721178AOpen up new usesOrganic active ingredientsOrganic chemistryAcacetinWater methanol
The invention relates to application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines, which aims at extracting acacetin form Huai flos chrysanthemums and preparing the estrogenic medicines by using the extracted acacetin. The acacetin of the flos chrysanthemums is obtained by the steps of performing tissue breaking on Huai flos chrysanthemums with acetonetwice, performing extraction twice, combining filtrates, and performing lower-temperature decompressed concentration to obtain a total extract; dispersing and dissolving the total extract by water, performing extraction with petroleum ether, ethyl acetate and n-butyl alcohol, taking dried ethyl acetate portions, performing dissolving with ethyl acetate, uniformly blending silica gel, then performing evaporation to dryness, performing silica gel column chromatography, performing spin drying on an eluent, performing dissolving in water, adding Toyopearl HW-40, performing gradient eluting with water and aqueous methanol in different proportions sequentially, sequentially treating the eluted part with sephadexLH-20, ODS, Silica gel and MCL Gel CHP-20 columns, and performing separation and purification in combination with methods for preparing high-efficient liquid phases and recrystallization. For the first time, the invention finds that the acacetin of the Huai flos chrysanthemum has anestrogen effect in bodies and plays a role in an estrogen receptor way, and a new purpose of the acacetin is opened up.
Owner:HENAN UNIV OF CHINESE MEDICINE
Method for extracting anti-cerebral ischemia substance from China rose and application of extracted anti-cerebral ischemia substance
InactiveCN103432240AHas anti-ischemic effectOpen up new usesCardiovascular disorderPlant ingredientsReflux extractionMedicine
The invention relates to a method for extracting an anti-cerebral ischemia substance from China rose and an application of the extracted anti-cerebral ischemia substance. The anti-cerebral ischemia substance is effectively extracted from the China rose, and the application of the China rose extract to the preparation of an anti-cerebral ischemia medicine is realized. The method comprises the following steps: grinding the China rose into powder, and performing reflux extraction by use of petroleum ether for 1 hour for degreasing; volatilizing petroleum ether from the degreased filter residue of the China rose powder until the product is dry to obtain China rose powder; soaking the China rose powder in ethanol for 0.5 hour; performing reflux extraction twice; filtering the extract liquid; performing reduced-pressure recovery of ethanol until ethanol smell disappears; concentrating; adding distilled water into the concentrate liquid and dispersing to obtain sample liquid; loading the sample liquid to AB-8 macroporous adsorption resin, eluting with distilled water and discarding the aqueous liquid; eluting with ethanol; performing reduced-pressure recovery of ethanol; concentrating until the product is dry powder to obtain total flavonoids of China rose, wherein the total flavonoids of China rose are effectively used for preparing an anti-cerebral ischemia medicine. According to the method and application of the extract provided by the invention, the raw materials are abundant, and the product is easy to prepare; the extract has an anti-cerebral ischemia function and is effectively used for preparing the anti-cerebral ischemia medicine.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of psoralen total flavonoid in preparation of medicaments for treating perimenopausal syndromes
InactiveCN106309543AAbundant raw materialsEasy to prepareSexual disorderPlant ingredientsPetroleum etherActive ingredient
The invention aims to provide application of psoralen total flavonoid in the preparation of medicaments for treating perimenopausal syndromes, which can effectively solve the problem of the application of the psoralen total flavonoids as the sole active ingredient in the preparation of medicaments for perimenopausal syndrome. The psoralen total flavonoids is prepared by crushing psoralen into coarse powder, refluxing and extracting with petroleum ether, degreasing, evaporating petroleum ether in psoralen slag, adding ethanol for soaking, refluxing and extracting, filtering, reducing pressure and recycling ethanol until no ethanol smell, adding distilled water to disperse to obtain medical liquor; eluting AB-8 macroporous adsorption resin on medical liquor with distilled water, and removing washing liquid; eluting by ethanol with the concentration of 10%, and removing elution liquid; eluting with ethanol with the concentration of 80%, collecting elution with the concentration of 80%, reducing pressure and recycling ethanol until no ethanol smell is left, freezing, drying, and crushing to obtain the psoralen total flavonoids. The application has the advantages of rich raw material, simple preparation method, easy operation and high production efficiency, and is effective for preparing medicaments for treating perimenopausal syndromes.
Owner:HENAN UNIV OF CHINESE MEDICINE
Application of cortex moutan extract in preparation of hypoglycaemic agent
InactiveCN104189109ADevelop medicinal valueOpen up new usesMetabolism disorderPlant ingredientsMedicineRoom temperature
The invention relates to application of cortex moutan extract in preparation of a hypoglycaemic agent and aims at solving the problem of preparation of the hypoglycaemic agent. According to the technical scheme, the cortex moutan extract is obtained by the following steps: taking a cortex moutan medicinal material, smashing cortex moutan into coarse powder, adding NaCl aqueous solution, soaking, then distilling and extracting, collecting distillate, cooling to room temperature, refrigerating, after cortex moutan phenol crystals are separated out, filtering to obtain primary crystals; adding NaCl into filtrate, distilling again, collecting distillate with the volume of being three times that of the filtrate, refrigerating, staying overnight, filtering to obtain secondary crystals, putting the primary crystals and the secondary crystals together, and drying under reduced pressure, so that the cortex moutan extract is obtained, wherein cortex moutan phenol mass content is more than 80%. Raw materials are available, a preparation method is simple, the obtained cortex moutan extract is effective and can be used for preparing the hypoglycaemic agent, so that the application of the cortex moutan extract in the preparation of the hypoglycaemic agent is realized; meanwhile, the cortex moutan extract also can be used for further realizing preparation of a drug used for treating diabetes, so that medicinal value of cortex moutan is increased and a new application of the cortex moutan is developed.
Owner:HENAN UNIV OF CHINESE MEDICINE
Fisetin with urate transporter 1 inhibitory activity as well as preparation method and application of fisetin
ActiveCN114644608AHigh purityEasy to prepareOrganic active ingredientsOrganic chemistryOrganosolvLicorice roots
The invention discloses fisetin with urate transporter 1 inhibitory activity and a preparation method and application thereof. The preparation method comprises the following steps: carrying out superfine grinding on licorice roots, and sieving to obtain superfine powder; soaking the superfine powder in ethanol, performing ultrasonic-assisted extraction, filtering and collecting filtrate, repeatedly extracting and filtering, and merging the filtrate to obtain a crude extract; concentrating the crude extract under reduced pressure to obtain an extract, redissolving the extract with water, extracting with an organic solvent, separating to obtain extract liquor, repeatedly extracting and combining the extract liquor; and carrying out macroporous resin coarse separation, chromatographic column fine grading and high performance liquid chromatography purification on the extract, and drying to obtain fisetin. The preparation method disclosed by the invention is simple and strong in specificity, the obtained fisetin has in-vitro urate transporter 1 inhibitory activity, and a new application of the glycyrrhiza uralensis fisetin is developed.
Owner:OCEAN UNIV OF CHINA
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