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Method for extracting anti-cerebral ischemia substance from China rose and application of extracted anti-cerebral ischemia substance

An anti-cerebral ischemia and Chinese rose technology, applied in the field of medicine, can solve the problem of unclear specific active components of anti-cerebral ischemia, and achieve the effects of improving medicinal value, abundant raw materials, and easy preparation.

Inactive Publication Date: 2013-12-11
HENAN UNIV OF CHINESE MEDICINE
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Problems solved by technology

But until now, no report on cerebral ischemia has been found, and the specific active ingredients for anti-cerebral ischemia are still unclear. The main active ingredient in the alcohol extract of rose flower is total flavonoids, and how to extract the total flavonoids of rose flower, As yet no public reports

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  • Method for extracting anti-cerebral ischemia substance from China rose and application of extracted anti-cerebral ischemia substance
  • Method for extracting anti-cerebral ischemia substance from China rose and application of extracted anti-cerebral ischemia substance
  • Method for extracting anti-cerebral ischemia substance from China rose and application of extracted anti-cerebral ischemia substance

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Embodiment Construction

[0010] Below in conjunction with specific circumstances, the specific embodiment of the present invention will be described in detail.

[0011] In practice, the present invention is realized by the following specific methods: Chinese rose is pulverized into medicinal powder of 60-80 mesh sieve, degreased with sherwood oil 10 times the weight of medicinal powder for reflux extraction; the degreased Chinese rose powder filter residue, The petroleum ether was evaporated to dryness to obtain rose pollen; the rose pollen was soaked in ethanol with 10 times the weight of the pollen and a volume concentration of 60% for 0.5 h, refluxed twice for 1 hour each time to obtain the extract, filtered, and the ethanol recovered under reduced pressure to No alcohol smell, concentrated to a concentrated solution with a relative density of 1.1-1.4, the concentrated solution is dispersed with distilled water to a sample solution equivalent to a crude drug content of 0.3g / ml; on the sample solutio...

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Abstract

The invention relates to a method for extracting an anti-cerebral ischemia substance from China rose and an application of the extracted anti-cerebral ischemia substance. The anti-cerebral ischemia substance is effectively extracted from the China rose, and the application of the China rose extract to the preparation of an anti-cerebral ischemia medicine is realized. The method comprises the following steps: grinding the China rose into powder, and performing reflux extraction by use of petroleum ether for 1 hour for degreasing; volatilizing petroleum ether from the degreased filter residue of the China rose powder until the product is dry to obtain China rose powder; soaking the China rose powder in ethanol for 0.5 hour; performing reflux extraction twice; filtering the extract liquid; performing reduced-pressure recovery of ethanol until ethanol smell disappears; concentrating; adding distilled water into the concentrate liquid and dispersing to obtain sample liquid; loading the sample liquid to AB-8 macroporous adsorption resin, eluting with distilled water and discarding the aqueous liquid; eluting with ethanol; performing reduced-pressure recovery of ethanol; concentrating until the product is dry powder to obtain total flavonoids of China rose, wherein the total flavonoids of China rose are effectively used for preparing an anti-cerebral ischemia medicine. According to the method and application of the extract provided by the invention, the raw materials are abundant, and the product is easy to prepare; the extract has an anti-cerebral ischemia function and is effectively used for preparing the anti-cerebral ischemia medicine.

Description

technical field [0001] The invention relates to medicine, in particular to a method for extracting anti-cerebral ischemia substances from rose flowers and its application. Background technique [0002] Ischemic cerebrovascular disease belongs to the scope of "ischemic stroke" in traditional Chinese medicine. It is a focal brain dysfunction caused by insufficient or interrupted local cerebral blood supply and oxygen supply. The common ones are transient ischemic attack, cerebral embolism, cerebral Thrombosis is a common and frequently-occurring disease that seriously threatens human life and health, and it is the main disease that causes death and disability. Ischemia-reperfusion injury (IRI) refers to the pathological phenomenon in which tissue damage is aggravated after a certain period of ischemia and blood supply is restored. At present, the intervention of drugs on ischemic brain injury has become an important research topic concerned by the society and the medical fiel...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P9/10A61K133/00
Inventor 苗明三方晓艳
Owner HENAN UNIV OF CHINESE MEDICINE
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