Application of total flavonoids of pueraria lobata in preparation of medicines for treating repeated ischemia

Abstract

The invention relates to application of total flavonoids of pueraria lobata in preparation of medicines for treating repeated ischemia. The problem that the total flavonoids of pueraria lobata are extracted from pueraria lobata and serve as the unique active ingredient in the preparation of the medicines for treating repeated ischemia can be effectively solved. The total flavonoids of pueraria lobata are prepared by the steps: grinding the pueraria lobata into coarse powder, performing reflux extraction with ethyl ether and degreasing, and removing the ethyl ether; volatilizing the ethyl ether from decoction dregs of the pueraria lobata, adding ethanol with a mass concentration of 80% for soaking, performing reflux extraction filtering, recovering the ethanol from the filtrate under reduced pressure until any alcohol does not exist, adding distilled water to disperse until dispersion equivalent to 0.3g / mL of the raw drug content is obtained, enabling the dispersion to pass through an AB-8 type macroporous resin, sequentially eluting with the distilled water, ethanol with the mass concentration of 10% and ethanol with the mass concentration of 80%, collecting the 80% of ethanol eluent, performing reduced pressure recovery on the ethanol until any alcohol does not exist, performing freeze drying, and grinding, thereby obtaining the total flavonoids of pueraria lobata. According to the preparation method disclosed by the invention, the total flavonoids of pueraria lobata can be effectively extracted from the pueraria lobata and are effectively used for treating the repeated ischemia, the novel application and medicinal values of the pueraria lobata are developed, and obvious economic and social benefits are achieved.

Description

technical field [0001] The invention relates to medicine, in particular to the application of total flavonoids of kudzu flower in the preparation of medicine for treating repeated cerebral ischemia. Background technique [0002] Cerebral ischemic diseases are a group of diseases in which blood supply to the brain, cerebellum or brainstem is insufficient in one or more parts due to various reasons, thereby causing corresponding neurological symptoms. Recurrent cerebral ischemia is the recurrent attack of cerebral ischemic symptoms. The etiology is complex and brings great harm to people's health. Therefore, people are very concerned about the treatment of repeated cerebral ischemia. However, although there are many drugs , due to various reasons, its curative effect is unsatisfactory, therefore, developing new medicine for the treatment of repeated cerebral ischemia is a technical problem that people hope to solve. [0003] Pueraria lobata (Willd.) Ohwi, the flower of Puerar...

AI Technical Summary

Problems solved by technology

But so far there is no public report on extracting the total flavonoids of Pueraria japonica from Pueraria japonica and using it to prepare drugs for the treatment of repeated cerebral ischemia

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