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Application of psoralen total flavonoid in preparation of medicaments for treating perimenopausal syndromes

A perimenopausal and psoralen technology, which is applied in the field of medicine, can solve problems such as the application of total flavonoids of psoralen, and achieve the effects of rich raw materials, simple preparation methods, and significant economic and social benefits

Inactive Publication Date: 2017-01-11
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] Although there are many drugs for the treatment of perimenopausal syndrome, there is no application of the total flavonoids of psoralen extracted from psoralen in the preparation of drugs for the treatment of perimenopausal syndrome.

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  • Application of psoralen total flavonoid in preparation of medicaments for treating perimenopausal syndromes
  • Application of psoralen total flavonoid in preparation of medicaments for treating perimenopausal syndromes
  • Application of psoralen total flavonoid in preparation of medicaments for treating perimenopausal syndromes

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Embodiment Construction

[0008] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0009] In the specific implementation of the present invention, the application of total flavonoids of psoralen as the only active part (ingredient) in the preparation of medicines for treating perimenopausal syndrome, the total flavonoids of psoralen is crushed into 20-30 mesh Sieve the coarse powder, first add 10 times the weight of the coarse powder to petroleum ether, reflux and extract for 1 hour, degrease, volatilize the psoralen dregs to dry petroleum ether, add 10 times the weight of the coarse powder, soak in 80% ethanol for 0.5 hours, and reflux and extract for 1 hour , filtered to obtain the first filtrate; the dregs plus coarse powder 10 times the weight, mass concentration 80% ethanol reflux extraction for 1h, filtered to obtain the second filtrate, the two filtrates were combined, and the ethanol was recovered under reduced press...

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Abstract

The invention aims to provide application of psoralen total flavonoid in the preparation of medicaments for treating perimenopausal syndromes, which can effectively solve the problem of the application of the psoralen total flavonoids as the sole active ingredient in the preparation of medicaments for perimenopausal syndrome. The psoralen total flavonoids is prepared by crushing psoralen into coarse powder, refluxing and extracting with petroleum ether, degreasing, evaporating petroleum ether in psoralen slag, adding ethanol for soaking, refluxing and extracting, filtering, reducing pressure and recycling ethanol until no ethanol smell, adding distilled water to disperse to obtain medical liquor; eluting AB-8 macroporous adsorption resin on medical liquor with distilled water, and removing washing liquid; eluting by ethanol with the concentration of 10%, and removing elution liquid; eluting with ethanol with the concentration of 80%, collecting elution with the concentration of 80%, reducing pressure and recycling ethanol until no ethanol smell is left, freezing, drying, and crushing to obtain the psoralen total flavonoids. The application has the advantages of rich raw material, simple preparation method, easy operation and high production efficiency, and is effective for preparing medicaments for treating perimenopausal syndromes.

Description

technical field [0001] The invention relates to medicine, in particular to the application of total psoralen flavonoids in the preparation of medicines for treating perimenopausal syndrome. Background technique [0002] Psoralea (scientific name: Psoralea corylifolia Linn.) also known as: Broken paper, poguzhi, scallions, seeds used as medicine, has the functions of invigorating kidney and strengthening yang, invigorating spleen and stomach, and can treat psoriasis and other skin diseases; used in Vietnam Its alcohol extract is used to treat rheumatism. Properties of medicine: bitter, pungent, warm. Return kidney, spleen channel. Tonify kidney and strengthen yang, strengthen essence and reduce urination, lumbago due to kidney deficiency, frequent urination, enuresis in children, kidney leakage, warming spleen and stopping diarrhea, invigorating qi and relieving asthma, used to treat impotence due to kidney deficiency, soreness and pain in waist and knees, nocturnal emissio...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61P15/00
CPCA61K36/487A61K2236/333A61K2236/35A61K2236/39A61K2236/55
Inventor 苗明三王灿田硕
Owner HENAN UNIV OF CHINESE MEDICINE
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